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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Unified protocol Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions

NCT05567640
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, Depressive Symptoms
Interventions
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), Space for depression, Space for resilience
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
1,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional

Unified Protocol for Adolescents (UP-A) Change Processes

NCT03102008
View directory record Official record
Conditions
Anxiety Disorders, Depression, Obsessive-Compulsive Disorder, Adolescent - Emotional Problem, Emotional Disorder
Interventions
Unified Protocol for Emotional Disorders in Adolescents (UP-A)
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 17 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Nov 26, 2018 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study

NCT04646174
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation, American Lung Association self-management strategies for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional

Assisting Obsessive Compulsive Disorder (OCD) Patients With Discontinuing Long-term Serotonin Reuptake Inhibitors (SRIs)

NCT02103621
View directory record Official record
Conditions
Obsessive Compulsive Disorder
Interventions
Unified Protocol (UP), Taper and Monitoring (TAP-M)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Sep 4, 2026, 7:49 PM EDT
Active, not recruiting Not applicable Interventional

Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use

NCT04871100
View directory record Official record
Conditions
Anxiety Disorder, Posttraumatic Stress Disorder, Hazardous Drinking
Interventions
Unified Protocol- Alcohol, Usual care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 4, 2026, 7:49 PM EDT
Recruiting Not applicable Interventional

Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults

NCT06060860
View directory record Official record
Conditions
Autism Spectrum Disorder, Depression, Anxiety
Interventions
Cognitive-Behavioral Therapy (CBT), Mindfulness-Based Cognitive Therapy (MBCT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 4, 2026, 7:49 PM EDT
Not listed Not applicable Interventional

Meeting an Unmet Need in Multiple Sclerosis

NCT05953519
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Unified Protocol
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Sep 4, 2026, 7:49 PM EDT
Not listed Not applicable Interventional

Treatment for Youth (Ages 8 to 16 Years Old) With Misophonia (U-HEAR)

NCT04365543
View directory record Official record
Conditions
Misophonia
Interventions
Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) for youth with misophonia, Psychoeducation and Relaxation Therapy (PRT)
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
8 Years to 16 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Coral Gables, Florida • St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Sep 4, 2026, 7:49 PM EDT
Recruiting Not applicable Interventional

Unified Protocol: Community Connections

NCT06038721
View directory record Official record
Conditions
Mental Health Issue, Anxiety Disorder, Depressive Disorder, Parenting
Interventions
The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Children, The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Adolescents
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
7 Years to 17 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional Results available

Stress, Emotion Regulation, and Alcohol in Women Veterans

NCT04393623
View directory record Official record
Conditions
Alcohol Use Disorder, Post Traumatic Stress Disorder
Interventions
Cognitive Reappraisal, Psychoeducation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Female only
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Leeds, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional

Enhancing Behavioral Treatment for Women With Pelvic Floor Disorders

NCT03623880
View directory record Official record
Conditions
Pelvic Floor Disorders, Anxiety, Urinary Urgency, Urinary Incontinence, Nocturia, Urinary Frequency/Urgency, Lower Urinary Tract Symptoms, Urinary Hesitancy, Urinary Straining
Interventions
Unified Protocol, Supportive Therapy
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Sep 4, 2026, 7:49 PM EDT
Not listed Not applicable Interventional

Smart Technology for Anorexia Nervosa Recovery

NCT05190926
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Smart-Treatment for Anorexia Nervosa Recovery (STAR), Present-focused Anorexia Nervosa Coping Treatment (PACT)
Behavioral
Lead sponsor
University of Kansas
Other
Eligibility
13 Years to 21 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Lawrence, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Sep 4, 2026, 7:49 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Battery-preserving Stimulation Patterns for Deep Brain Stimulation

NCT02569021
View directory record Official record
Conditions
Parkinsons Disease, Essential Tremor
Interventions
Biphasic DBS stimulation, Unified Parkinson's Disease Rating Scale, Tremor Rating Scale, Kinesia accelerometer, Trigno wireless system, GaitRite walking assessment.
Device · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 23, 2016 · Synced Sep 4, 2026, 7:49 PM EDT
Not listed Not applicable Interventional

Mindfulness-based Dance/Movement Therapy for Chronic Low Back Pain

NCT03986489
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Mindfulness-based dance/movement therapy (M-DMT), Chronic pain social support group
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Sep 4, 2026, 7:49 PM EDT
Recruiting Phase 3 Interventional

Affirmative Family and Individual Psychotherapy for Sexual and Gender Minority Adults and Their Nonaccepting Parents

NCT05766592
View directory record Official record
Conditions
Mental Health Issue, Parent-Child Relations
Interventions
LGBTQ-affirmative CBT, ABFT-SGM
Behavioral
Lead sponsor
Yale University
Other
Eligibility
20 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transdiagnostic Treatment Personalization

NCT04584879
View directory record Official record
Conditions
Anxiety Disorders, Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
Interventions
Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
Behavioral
Lead sponsor
Shannon E. Sauer-Zavala
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Unified Intervention for Young Gay and Bisexual Men's Minority Stress, Mental Health, and HIV Risk

NCT02929069
View directory record Official record
Conditions
HIV, Acquired Immunodeficiency Syndrome
Interventions
ESTEEM, CMHT, VCT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
New Haven, Connecticut • Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Sep 4, 2026, 7:49 PM EDT
Recruiting Not applicable Interventional

Comparing Two Different Emotion Therapies for Autistic Youth and Young Adults

NCT06158581
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
The Emotion Awareness and Skills Enhancement Program, The Unified Protocol
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
10 Years to 30 Years
Enrollment
470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Tuscaloosa, Alabama • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 4, 2026, 7:49 PM EDT
Not listed Not applicable Interventional

Randomized Clinical Trial of Supplementing Brief Psychotherapy With a Mobile App

NCT06555094
View directory record Official record
Conditions
Suicidal Ideation, Suicide, Suicide Attempt
Interventions
Ecological momentary assessment (EMA), Treatment as usual (TAU), Brief skills sessions plus EMI skills practice prompts
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Sep 4, 2026, 7:49 PM EDT
Recruiting No phase listed Observational

Unified Network for Integrated Fluid Collection at Yale

NCT07689864
View directory record Official record
Conditions
Molecular Residual Disease, Cancer
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 4, 2026, 7:49 PM EDT
Completed Not applicable Interventional Results available

Community Study of Outcome Monitoring for Emotional Disorders in Teens

NCT02567266
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Unified Protocol for Adolescents (UP-A), Youth Outcomes Questionnaire, Treatment as Usual
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 18 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
West Hartford, Connecticut • Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 17, 2021 · Synced Sep 4, 2026, 7:49 PM EDT
Suspended Not applicable Interventional

Stress, Anxiety, and Mood Group Therapy

NCT03855683
View directory record Official record
Conditions
Depressive Disorders, Anxiety Disorders
Interventions
Unified Protocol for The Treatment of Emotional Disorders
Behavioral
Lead sponsor
Palo Alto University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Altos, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Sep 4, 2026, 7:49 PM EDT
Not listed Not applicable Interventional

The SEMS Project: Staying Employed With MS

NCT03647904
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
SEMS Project
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 4, 2026, 7:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services

NCT06651086
View directory record Official record
Conditions
Autism Spectrum Disorder, Executive Functioning
Interventions
Unstuck and On Target, Unified Protocol for Children
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
6 Years to 99 Years
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
2
States / cities
San Diego, California • Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 4, 2026, 7:49 PM EDT