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ClinicalTrials.gov public records Last synced Oct 6, 2026, 9:25 PM EDT

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Showing 49–72 of 76 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Upper Airway Therapy Clear all
Recruiting No phase listed Observational

Predicting Outcomes in Hypoglossal Nerve Stimulation Therapy With Stimulated Upper Airway Mechanics

NCT05429983
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Timeline
2022 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 6, 2026, 9:25 PM EDT
Recruiting Not applicable Interventional

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

NCT05988385
View directory record Official record
Conditions
Obstructive Sleep Apnea, Cognitive Decline
Interventions
Positive airway pressure, Oral appliance therapy, Positional therapy
Device
Lead sponsor
California Pacific Medical Center Research Institute
Other
Eligibility
55 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Tucson, Arizona • New York, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 6, 2026, 9:25 PM EDT
Active, not recruiting Not applicable Interventional

Safety and Effectiveness of the Genio® bilAteral Stimulation for Treatment of Complete Concentric CollapsE and OSA.

NCT05592002
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Genio System
Device
Lead sponsor
Nyxoah S.A.
Industry
Eligibility
22 Years to 75 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
16
States / cities
Colorado Springs, Colorado • Boca Raton, Florida • Miami, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sleep-Disordered Breathing in Chronic SCI

NCT02176928
View directory record Official record
Conditions
Spinal Cord Injury, Sleep Apnea, Obstructive
Interventions
AutoPAP, Sham PAP
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
4
States / cities
Miami, Florida • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Airway Obstruction in Infants With Lower Respiratory Infections

NCT00435994
View directory record Official record
Conditions
Bronchiolitis, Respiratory Syncytial Virus Infections
Interventions
Inhaled primatene will be given as a breathing treatment, Nasal Washing
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
2 Months to 2 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 1, 2016 · Synced Oct 6, 2026, 9:25 PM EDT
Recruiting No phase listed Observational

Pediatric Post-Approval Registry

NCT04457154
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Inspire Upper Airway Stimulation System
Device
Lead sponsor
Inspire Medical Systems, Inc.
Industry
Eligibility
18 Years to 21 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
8
States / cities
Aurora, Colorado • Atlanta, Georgia • Durham, North Carolina + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 6, 2026, 9:25 PM EDT
Recruiting No phase listed Observational

Laryngeal Cryotherapy for Refractory Neurogenic Cough

NCT05665244
View directory record Official record
Conditions
Upper-Airway Cough Syndrome
Interventions
Laryngeal cryotherapy, Cryoprobe
Procedure · Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional

Characterizing Upper Airway Collapse to Guide Patient Selection for Oral Appliance Therapy for Obstructive Sleep Apnea

NCT02489591
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Oral appliance, BluePro oral appliance
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Oct 6, 2026, 9:25 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Obstructive Sleep Apnea in Pregnancy

NCT02383706
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Pregnancy, Obesity, Morbid
Interventions
ApneaLink Air, Berlin Quesionnaire, Epworth Sleepiness Scale, STOP-BANG questionnaire, Physical exam
Device · Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 19, 2019 · Synced Oct 6, 2026, 9:25 PM EDT
Terminated Not applicable Interventional Results available

Effect of Upper Airway Stimulation on Vascular Function in Obstructive Sleep Apnea

NCT03051165
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Hypoglossal Nerve Stimulation Treatment Withdrawal
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional Results available

Vivaer® Procedure for Treatment of Nasal Airway Obstruction Study

NCT04549545
View directory record Official record
Conditions
Nasal Airway Obstruction
Interventions
Vivaer ARC Stylus, Sham
Device
Lead sponsor
Aerin Medical
Industry
Eligibility
18 Years to 85 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
12
States / cities
Roseville, California • Torrance, California • Coral Springs, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional

Cervical Spine Biomechanics During Endotracheal Intubation

NCT01369381
View directory record Official record
Conditions
Spinal Diseases, Other Biomechanical Lesions of Cervical Region, Tracheal Intubation Morbidity
Interventions
Endotracheal intubation
Procedure
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 80 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 7, 2012 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional

Effects of Upper Airway Muscle Training on OSA

NCT02502942
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Upper Airway Muscle Exercise, Sham Exercise
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 79 Years
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2019 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Phase 2 Interventional

Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea

NCT03189173
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Oral appliance, Oxygen, Oral appliance plus oxygen, No treatment
Device · Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 79 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 6, 2026, 9:25 PM EDT
Recruiting Phase 2 Interventional

Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea

NCT00695214
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Propofol sedation
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2035
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional Results available

Prospective Use of Awake Endoscopy for Inspire Activation

NCT03990298
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Awake endoscopy
Diagnostic Test
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Oct 6, 2026, 9:25 PM EDT
Not listed No phase listed Observational

Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry

NCT02907398
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Inspire therapy, No intervention
Device · Other
Lead sponsor
Inspire Medical Systems, Inc.
Industry
Eligibility
Not listed
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
53
States / cities
Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 43 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional Results available

Upper Airway Physical Therapy for the Treatment of Obstructive Sleep Apnea

NCT02109731
View directory record Official record
Conditions
Obstructive Sleep Apnea Syndrome
Interventions
Negative airway pressure delivery
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Oct 6, 2026, 9:25 PM EDT
Not listed Not applicable Interventional

Oscillating Positive Expiratory Pressure (OPEP) Therapy in Trauma Patients With Multiple Rib Fractures

NCT04100512
View directory record Official record
Conditions
Rib Fractures, Respiratory Complication
Interventions
Oscillating Positive Expiratory Pressure Device, Incentive spirometry
Device
Lead sponsor
Poudre Valley Health System
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Loveland, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 19, 2022 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional Results available

Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism

NCT01503164
View directory record Official record
Conditions
Obstructive Sleep Apnea, Sleep Apnea, Sleep-disordered Breathing
Interventions
Positive Pressure Therapy (PAP), LifeStyle Counseling
Device · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 75 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional

Multidisciplinary Approach to the Treatment of Insomnia and Comorbid Sleep Apnea

NCT01785303
View directory record Official record
Conditions
Obstructive Sleep Apnea, Insomnia
Interventions
CBT-I, CPAP
Behavioral · Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 18, 2019 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

NCT03736382
View directory record Official record
Conditions
Obstructive Sleep Apnea, Spinal Cord Injuries
Interventions
Mild intermittent hypoxia, Sham protocol, Continuous positive airway pressure (CPAP)
Other
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 60 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
2
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 6, 2026, 9:25 PM EDT
Completed Not applicable Interventional Results available

Comparative Outcomes Management With Electronic Data Technology (COMET) Study

NCT01461473
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Positive Airway Pressure (PAP), Oral Appliance (OA)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
4
States / cities
Redwood City, California • Boston, Massachusetts • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Oct 6, 2026, 9:25 PM EDT
Recruiting Phase 4 Interventional

A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults

NCT07679282
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin
Device · Drug
Lead sponsor
Sairam Parthasarathy
Other
Eligibility
18 Years and older
Enrollment
2,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
4
States / cities
Tucson, Arizona • Redwood City, California • Miami, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 6, 2026, 9:25 PM EDT