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ClinicalTrials.gov public records Last synced Oct 5, 2026, 11:19 PM EDT

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Showing 25–48 of 52 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Usual Brand Cigarette Smoking Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)

NCT02538042
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (0.07 mg), MCE-
Drug · Behavioral
Lead sponsor
Francis McClernon, Ph.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Methods Project 4: Clinical Trial - Amended

NCT03111537
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Cigarettes, E-Cigarette, Nicotine Gum or Lozenge
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
3
States / cities
Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 5, 2026, 11:19 PM EDT
Recruiting Not applicable Interventional

Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV

NCT03862924
View directory record Official record
Conditions
HIV
Interventions
Standardized Research Electronic Cigarette
Device
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes

NCT04188197
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking, Tobacco Dependence, Tobacco Use Cessation
Interventions
JUUL
Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 5, 2026, 11:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability

NCT07564648
View directory record Official record
Conditions
Cigarette Addiction, Tobacco Use Disorder
Interventions
Biospecimen Collection, Questionnaire Administration, Cigarette Purchase Task, Cross-Price Elasticity Task, Daily Diary Surveys, Progressive Ratio Task
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

NCT03691350
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration
Procedure · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 52 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Post-Market Surveillance of Tobacco Products

NCT04255459
View directory record Official record
Conditions
Smoking, Tobacco, Smoking Behaviors
Interventions
Moist Snuff, Camel Snus, Cigarettes, No tobacco usage
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
19 Years and older
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
6
States / cities
DeLand, Florida • Miramar, Florida • Stockbridge, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use

NCT06230159
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Non-menthol Cigarette Smoking, Menthol Cigarette Smoking, Synthetic Cooling Agent Cigarette Smoking, Usual Brand Cigarette Smoking, Spirometry, Questionnaire Administration, Nasal Epithelial Lining Fluid
Behavioral · Diagnostic Test · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 29 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching From Usual Brand Cigarettes to a Tobacco-heating Cigarette or Snus

NCT02061917
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Tobacco-Heating Cigarette, Snus (Smokeless Tobacco), Tobacco-Burning Cigarette
Other
Lead sponsor
R.J. Reynolds Tobacco Company
Industry
Eligibility
28 Years to 55 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
5
States / cities
Daytona Beach, Florida • Boise, Idaho • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2016 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

THC Crossover Study

NCT04429568
View directory record Official record
Conditions
THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions
Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2024 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

NCT02964182
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions
Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo
Drug · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette

NCT05855343
View directory record Official record
Conditions
Smoking Cessation
Interventions
BIDI Stick e-cigarette
Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Results available

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

NCT06356610
View directory record Official record
Conditions
Tobacco Use
Interventions
Product A, Product B, Product C, Product D, Product E, Product F
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes

NCT03856515
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
Drug · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years and older
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Results available

Puff Biofeedback to Reduce Smoking Reinforcement

NCT05644002
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Puff Topography Biofeedback Training, Control
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
19 Years to 55 Years
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparison of Hookah and Cigarette Smoking

NCT00992550
View directory record Official record
Conditions
Smoking
Interventions
Cigarette, Hookah
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 24, 2013 · Synced Oct 5, 2026, 11:19 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior

NCT03840694
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Withdrawal
Interventions
Smoking Abstinence, Ad Lib Smoking
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Results available

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

NCT03612960
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Very low nicotine content cigarettes, Normal nicotine content cigarettes
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder

NCT02990455
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking Toxicity
Interventions
Reduced nicotine cigarettes
Drug
Lead sponsor
Battelle Memorial Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sugars in Cigarettes

NCT05308316
View directory record Official record
Conditions
Tobacco Use
Interventions
Cigarettes with added sucrose
Other
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Controlled Trial to Evaluate the Impact of ZYN Nicotine Pouch Products on Cigarette Usage and BoExp in Adult Smokers Over a 12-week Period

NCT06568900
View directory record Official record
Conditions
Tobacco Use
Interventions
cigarette smoking, tobacco flavored and unflavored pouch, unrestricted flavor options pouch
Other
Lead sponsor
Swedish Match AB
Industry
Eligibility
22 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 23, 2024 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women

NCT04033237
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Very low nicotine content cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
2
States / cities
Lexington, Kentucky • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD231005 Nicotine Pouch Biomarkers of Exposure

NCT06303115
View directory record Official record
Conditions
Tobacco Use, Smoking
Interventions
Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine, Nicotine Pouch P1013218, 10 mg nicotine, Nicotine Pouch P1012919, 12 mg nicotine, Smoking Abstinence, Continued UB cigarette smoking
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2025 · Synced Oct 5, 2026, 11:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors

NCT02000921
View directory record Official record
Conditions
Tobacco Addiction, Dual Tobacco Use
Interventions
VLNC cigarettes, Combusted Products, Non-combusted products, CN cigarettes
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 31, 2017 · Synced Oct 5, 2026, 11:19 PM EDT