- Conditions
- Nicotine Dependence
- Interventions
- Nicotine patch, ENDS, Placebo patch, Placebo ENDS
- Drug · Other
- Lead sponsor
- Duke University
- Other
- Eligibility
- 18 Years to 65 Years
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2022
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
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Showing 1–24
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- Conditions
- Smoking, Smoking Cessation
- Interventions
- Coordinated Care, Usual Care
- Other
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 633 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011 – 2015
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Cigarette Smoking
- Interventions
- High-ventilated cigarette alone, Low-ventilated cigarette alone, High- and low-ventilated cigarette with high-ventilated cigarettes increasing in price, Low- and high-ventilated cigarette with high-ventilated cigarettes increasing in price, Usual, high- and low-ventilated cigarette with usual cigarettes increasing in price.
- Behavioral
- Lead sponsor
- Virginia Polytechnic Institute and State University
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 89 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Roanoke, Virginia
- Conditions
- Tobacco Smoking Behavior
- Interventions
- Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control
- Other
- Lead sponsor
- Milton S. Hershey Medical Center
- Other
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 37 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2017
- U.S. locations
- 1
- States / cities
- Hershey, Pennsylvania
- Conditions
- HIV, STI, Emotional Disturbances, Mental Disorder
- Interventions
- HIV/STI Prevention Intervention, General Health Control Intervention
- Behavioral
- Lead sponsor
- University of Pennsylvania
- Other
- Eligibility
- 14 Years to 17 Years
- Enrollment
- 108 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2014 – 2016
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Smoking Behaviors
- Interventions
- Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions.
- Drug
- Lead sponsor
- JT International SA
- Industry
- Eligibility
- 22 Years to 65 Years
- Enrollment
- 55 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026
- U.S. locations
- 2
- States / cities
- Knoxville, Tennessee • San Antonio, Texas
- Conditions
- Cigarette Smoking
- Interventions
- Best Practices, Financial Incentives, Nicotine Replacement Therapy
- Behavioral · Drug
- Lead sponsor
- University of Vermont
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 198 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2020
- U.S. locations
- 1
- States / cities
- Burlington, Vermont
- Conditions
- Electronic Cigarette Use
- Interventions
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Subject Usual Brand ENDS
- Other
- Lead sponsor
- Cheerain HK Limited
- Industry
- Eligibility
- 22 Years to 59 Years
- Enrollment
- 29 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020 – 2021
- U.S. locations
- 2
- States / cities
- Cypress, California • Overland Park, Kansas
- Conditions
- Cigarette Addiction, Tobacco Use Disorder
- Interventions
- Biospecimen Collection, Questionnaire Administration, Cigarette Purchase Task, Cross-Price Elasticity Task, Daily Diary Surveys, Progressive Ratio Task
- Behavioral
- Lead sponsor
- Ohio State University Comprehensive Cancer Center
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 48 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- Columbus, Ohio
- Conditions
- Tobacco Dependence, Schizophrenia
- Interventions
- Sampling Research Cigarettes
- Combination Product
- Lead sponsor
- University of Maryland, Baltimore
- Other
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 31 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2022
- U.S. locations
- 1
- States / cities
- Catonsville, Maryland
- Conditions
- Smoking, Tobacco Use
- Interventions
- Electronic Cigarette
- Behavioral
- Lead sponsor
- Medical University of South Carolina
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 638 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018 – 2022
- U.S. locations
- 1
- States / cities
- Charleston, South Carolina
- Conditions
- Cigarette Smoking
- Interventions
- Tobacco-Heating Cigarette, Snus (Smokeless Tobacco), Tobacco-Burning Cigarette
- Other
- Lead sponsor
- R.J. Reynolds Tobacco Company
- Industry
- Eligibility
- 28 Years to 55 Years
- Enrollment
- 163 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2007 – 2009
- U.S. locations
- 5
- States / cities
- Daytona Beach, Florida • Boise, Idaho • Portland, Oregon + 2 more
- Conditions
- Cigarette Smoking, Nicotine Dependence
- Interventions
- Internet Smoking Cessation Web Site
- Behavioral
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 146 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012 – 2016
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Adolescent Behavior, Tobacco Use, E-Cig Use
- Interventions
- AD IT UP media literacy intervention, Usual health education curriculum
- Behavioral
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 13 Years to 17 Years
- Enrollment
- 318 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking, Tobacco Dependence, Tobacco Use Cessation
- Interventions
- JUUL
- Other
- Lead sponsor
- Rose Research Center, LLC
- Industry
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 50 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2021
- U.S. locations
- 2
- States / cities
- Charlotte, North Carolina • Raleigh, North Carolina
- Conditions
- Nicotine Dependence
- Interventions
- Nicotine Patches, Denicotinized Cigarettes
- Drug
- Lead sponsor
- Duke University
- Other
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 257 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2009 – 2014
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Interventions
- Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS, Creme Brulee flavored JUUL 5% ENDS, VUSE Solo e-cigarette, Nicorette White Ice Mint 4mg nicotine polacrilex gum, Usual Brand combustible cigarette
- Other
- Lead sponsor
- Juul Labs, Inc.
- Industry
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 67 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018
- U.S. locations
- 1
- States / cities
- Overland Park, Kansas
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Interventions
- Product A, Product B, Product C, Product D, Product E
- Other
- Lead sponsor
- RAI Services Company
- Industry
- Eligibility
- 21 Years to 60 Years
- Enrollment
- 42 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020
- U.S. locations
- 1
- States / cities
- Knoxville, Tennessee
- Conditions
- Smoking
- Interventions
- Ecig group 1
- Other
- Lead sponsor
- Truth Initiative
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 117 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2014 – 2016
- U.S. locations
- 1
- States / cities
- Washington D.C., District of Columbia
- Conditions
- Cannabis Intoxication
- Interventions
- Cannabis
- Drug
- Lead sponsor
- University of California, San Diego
- Other
- Eligibility
- 21 Years to 55 Years
- Enrollment
- 199 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2019
- U.S. locations
- 1
- States / cities
- San Diego, California
- Conditions
- Tobacco Dependence
- Interventions
- Reduced Nicotine Content Cigarettes, Same Nicotine Content Cigarettes
- Drug
- Lead sponsor
- Milton S. Hershey Medical Center
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 280 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2018
- U.S. locations
- 2
- States / cities
- Washington D.C., District of Columbia • Hershey, Pennsylvania
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
- Interventions
- Smoking Prevention Usual Care, Counseling Intervention
- Behavioral
- Lead sponsor
- M.D. Anderson Cancer Center
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 469 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2002 – 2016
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- HIV
- Interventions
- Standardized Research Electronic Cigarette
- Device
- Lead sponsor
- Brown University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 72 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Cigarette Smoking
- Interventions
- Puff Topography Biofeedback Training, Control
- Behavioral
- Lead sponsor
- Rutgers, The State University of New Jersey
- Other
- Eligibility
- 19 Years to 55 Years
- Enrollment
- 154 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2023
- U.S. locations
- 1
- States / cities
- New Brunswick, New Jersey