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ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:12 AM EDT

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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Vaginal Misoprostol Clear all
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss

NCT02141555
View directory record Official record
Conditions
Spontaneous Abortion in First Trimester
Interventions
Vaginal Misoprostol, Buccal Misoprostol
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Phase 3 Interventional Results available

Comparative Effectiveness of Pregnancy Failure Management Regimens

NCT02012491
View directory record Official record
Conditions
Spontaneous Abortion
Interventions
Misoprostol, Mifepristone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
3
States / cities
Sacramento, California • The Bronx, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 18, 2019 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Immune Modulation by Misoprostol

NCT02259309
View directory record Official record
Conditions
Gynecological Infection
Interventions
Misoprostol - buccal, Misoprostol - vaginal
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy

NCT05342974
View directory record Official record
Conditions
Abortion Early
Interventions
Atorvastatin, Misoprostol
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Misoprostol for Non-Viable Pregnancies

NCT00426491
View directory record Official record
Conditions
Abortifacient Agents, Nonsteroidal, Abortion, Incomplete, Misoprostol, Pregnancy
Interventions
Misoprostol
Drug
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 40 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2006
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Feb 8, 2008 · Synced Oct 21, 2026, 12:12 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Pharmacokinetics and Safety of the 100 Mcg Misoprostol Vaginal Insert (MVI 100)

NCT00528255
View directory record Official record
Conditions
Cervical Ripening, Induction of Labor
Interventions
Misoprostol Vaginal Insert (MVI 100)
Drug
Lead sponsor
Ferring Pharmaceuticals
Industry
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
U.S. locations
6
States / cities
Phoenix, Arizona • Long Beach, California • Orange, California + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2012 · Synced Oct 21, 2026, 12:12 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor

NCT02777190
View directory record Official record
Conditions
Labor; Forced or Induced, Affecting Fetus or Newborn, Pregnancy
Interventions
Misoprostol
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Oct 21, 2026, 12:12 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Outpatient Transcervical Balloon For Induction of Labor

NCT05798728
View directory record Official record
Conditions
Induced Vaginal Delivery, Induced; Birth
Interventions
Outpatient transcervical foley balloon, Inpatient Vaginal Misoprostol
Procedure
Lead sponsor
Hurley Medical Center
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Oct 21, 2026, 12:12 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Study of Effect of Vaginal ph and Acidification of Vaginal Misoprostol on Its Efficacy for Induction of Midtrimester Abortion

NCT01241045
View directory record Official record
Conditions
To Evaluate the Impact of the Vaginal Ph and Acidification of Vaginal Misoprostol on Its Efficacy in Facilitating Induction of Mid-trimester Abortion.
Interventions
Not listed
Lead sponsor
Ain Shams University
Other
Eligibility
15 Years to 45 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Cairo, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2010 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Not applicable Interventional Results available

Cervical Ripening for Induction of Labor: Misoprostol Versus Oxytocin in Conjunction With Foley Balloon

NCT01139801
View directory record Official record
Conditions
Induction of Labor
Interventions
Oxytocin, Misoprostol
Drug
Lead sponsor
Aultman Health Foundation
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 24, 2018 · Synced Oct 21, 2026, 12:12 AM EDT
Terminated Not applicable Interventional Results available

Outpatient Foley Catheter Compared to Usual Inpatient Care for Labor Induction

NCT02546193
View directory record Official record
Conditions
Pregnancy
Interventions
Foley catheter, Misoprostol
Device · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Oct 21, 2026, 12:12 AM EDT
Terminated Not applicable Interventional Results available

Cervical Ripening in Postmenopausal Women

NCT02534883
View directory record Official record
Conditions
Stenosis of Cervix
Interventions
Misoprostol, Placebo
Drug
Lead sponsor
St. Louis University
Other
Eligibility
45 Years to 85 Years · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Adjunctive Misoprostol Treatment on Blood Loss at Vaginal Delivery

NCT02411916
View directory record Official record
Conditions
Postpartum Hemorrhage
Interventions
misoprostol
Biological
Lead sponsor
New York City Health and Hospitals Corporation
Other
Eligibility
18 Years and older · Female only
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial

NCT02639429
View directory record Official record
Conditions
Obesity, Labor Induction, Cesarean Delivery
Interventions
Vaginal Misoprostol, Foley Balloon + Vaginal Misoprostol
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2019 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Elective Induction of Nulliparous Labor

NCT01076062
View directory record Official record
Conditions
Pregnancy
Interventions
Induction of Labor
Procedure
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 40 Years · Female only
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Combined Vaginal Misoprostol and Perivascular Vasopressin

NCT03815344
View directory record Official record
Conditions
Leiomyoma, Laparoscopy, Uterine Myomectomy
Interventions
Standard, Standard-vaginal misoprostol
Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 21, 2026, 12:12 AM EDT
Withdrawn Phase 4 Interventional

Misoprostol in Office Hysteroscopy and Endometrial Biopsy

NCT03547778
View directory record Official record
Conditions
Office Hysteroscopy and Endometrial Biopsy
Interventions
Misoprostol 50 mcg pesssary, Placebos
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 70 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2021 · Synced Oct 21, 2026, 12:12 AM EDT
Completed No phase listed Observational

Labor Induction With Oral Versus Vaginal Misoprostol

NCT04755218
View directory record Official record
Conditions
Pregnancy, Labor, Induced
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
10 Years and older · Female only
Enrollment
2,546 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 5, 2024 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Phase 3 Interventional Results available

Induction With Misoprostol: Oral Mucosa Versus Vaginal Epithelium (IMPROVE)

NCT02408315
View directory record Official record
Conditions
Pregnancy
Interventions
misoprostol/placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 45 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 13, 2022 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Misoprostol Alone to Dilapan With Misoprostol and Comparing Buccal to Vaginal Misoprostol

NCT02363556
View directory record Official record
Conditions
Second Trimester Abortions
Interventions
Misoprostol administered vaginally, Misoprostol administered buccally, Misoprostol administered vaginally with Dilapan, Misoprostol administered buccally with Dilapan
Procedure
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Oct 21, 2026, 12:12 AM EDT
Recruiting Early Phase 1 Interventional

Induction of Labor in Morbidly Obese Patients

NCT06199154
View directory record Official record
Conditions
Morbid Obesity, Pregnancy
Interventions
Misoprostol
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 21, 2026, 12:12 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Labor Protocol Study

NCT04004845
View directory record Official record
Conditions
Vaginal Delivery, Labor, Induced; Birth
Interventions
Cytotec, oxytocin, Cervical Foley Balloon
Drug · Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 4, 2022 · Synced Oct 21, 2026, 12:12 AM EDT
Terminated Phase 4 Interventional Results available

Buccal Versus Vaginal Misoprostol for Third Trimester Induction of Labor

NCT01519765
View directory record Official record
Conditions
Pregnancy
Interventions
Buccal Misoprostol, Vaginal misoprostol
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Oct 21, 2026, 12:12 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E

NCT03134183
View directory record Official record
Conditions
Abortion, Second Trimester
Interventions
Vaginal Misoprostol, Buccal Misoprostol
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 18, 2018 · Synced Oct 21, 2026, 12:12 AM EDT