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ClinicalTrials.gov public records Last synced Sep 30, 2026, 2:33 AM EDT

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Showing 25–48 of 61 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Vaginal hysterectomy Clear all
Completed No phase listed Observational Accepts healthy volunteers

Does BMI Influence Pain Follow vNOTE Surgery

NCT05230407
View directory record Official record
Conditions
Obese, Surgery, Pain, Postoperative
Interventions
Visual analog scale (VAS) assesment of pain
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced Sep 30, 2026, 2:33 AM EDT
Completed No phase listed Observational

Advanced Biomarker Assessment in Pelvic Organ Prolapse

NCT03642054
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 24, 2021 · Synced Sep 30, 2026, 2:33 AM EDT
Not listed Not applicable Interventional

Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer

NCT00956670
View directory record Official record
Conditions
Lymphedema, Stage IA Cervical Cancer, Stage IA Uterine Corpus Cancer, Stage IA Vulvar Cancer, Stage IB Cervical Cancer, Stage IB Uterine Corpus Cancer, Stage IB Vulvar Cancer, Stage II Uterine Corpus Cancer, Stage II Vulvar Cancer, Stage IIA Cervical Cancer, Stage IIIA Vulvar Cancer, Stage IIIB Vulvar Cancer, Stage IIIC Vulvar Cancer, Stage IVB Vulvar Cancer
Interventions
Quality-of-Life Assessment, Questionnaire Administration, Study of High Risk Factors, Therapeutic Conventional Surgery, Therapeutic Laparoscopic Surgery, Therapeutic Lymphadenectomy
Other · Procedure
Lead sponsor
Gynecologic Oncology Group
Network
Eligibility
18 Years and older · Female only
Enrollment
1,055 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
213
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 160 more
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Not applicable Interventional

Protein Expression as a Potential Diagnostic Biomarker of Cervical Dysplasia and/or Cancer

NCT00003384
View directory record Official record
Conditions
Precancerous Condition, Stage 0 Cervical Cancer
Interventions
Cervical Papanicolaou Test, Conization, Laboratory Biomarker Analysis
Other · Procedure
Lead sponsor
Gynecologic Oncology Group
Network
Eligibility
18 Years and older · Female only
Enrollment
684 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1998
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 29, 2015 · Synced Sep 30, 2026, 2:33 AM EDT
Terminated Not applicable Interventional

Pelvic Floor Support After Laparoscopic Hysterectomy for Benign Conditions: A Randomized Controlled Trial Comparing Vaginal Cuff Closure Techniques

NCT03753516
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Laparoscopic - Vaginal Cuff Closure, Vaginal- Vaginal Cuff Closure
Procedure
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Not applicable Interventional

Vaginal Cuff Closure in Robotic Hysterectomy

NCT02696239
View directory record Official record
Conditions
Complications of Medical Care
Interventions
Vaginal cuff closure
Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Sep 30, 2026, 2:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Difference in Pain, Quality of Life Following Vaginal Hysterectomy With Vaginal Reconstruction Versus Robotic Colpopexy?

NCT02049996
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Not listed
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 9, 2016 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does 3D Laparoscopy Improve Vaginal Cuff Suture Time?

NCT02192606
View directory record Official record
Conditions
Uterine Fibroids, Abnormal Uterine Bleeding, Pelvic Pain, Adenomyosis
Interventions
Storz 3D Laparoscopy System, 2D Laparoscopy
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Sep 30, 2026, 2:33 AM EDT
Recruiting Phase 3 Interventional

Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

NCT06969326
View directory record Official record
Conditions
Postoperative Bleeding, Gender Dysphoria, Hysterectomy
Interventions
Use of topical estradiol, No intervention
Drug · Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Sep 30, 2026, 2:33 AM EDT
Recruiting No phase listed Observational

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

NCT05051722
View directory record Official record
Conditions
Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia, Adnexal Mass, Ovarian Cancer
Interventions
Vaginal Fluid Collection, Blood Collection
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
3,110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
25
States / cities
Phoenix, Arizona • Jacksonville, Florida • Miami, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Sep 30, 2026, 2:33 AM EDT
Active, not recruiting Phase 1 Interventional

Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer

NCT03932409
View directory record Official record
Conditions
Endometrial Cancer
Interventions
Pembrolizumab, Vaginal cuff brachytherapy (VCB), Paclitaxel, Carboplatin
Drug · Radiation
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older · Female only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
2
States / cities
New Orleans, Louisiana • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Sep 30, 2026, 2:33 AM EDT
Not listed Phase 4 Interventional

PROJECT PREVENT: Metronidazole Antibiotic Per Vagina Before Hysterectomy: Is Additional Antibiotic Prophylaxis Beneficial?

NCT04478617
View directory record Official record
Conditions
Post-Op Infection
Interventions
Metronidazole Vaginal
Drug
Lead sponsor
New York Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
New York, New York • Valhalla, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Phase 1 Interventional

Pelvic IMRT With Tomotherapy: A Phase I Feasibility Study in Post-Hysterectomy Cervical Cancer Patients

NCT00359866
View directory record Official record
Conditions
Uterine Cervical Neoplasms
Interventions
IMRT with tomotherapy
Radiation
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 15, 2016 · Synced Sep 30, 2026, 2:33 AM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine in Vaginal Hysterectomy

NCT03907033
View directory record Official record
Conditions
Vaginal Hysterectomy
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 15, 2021 · Synced Sep 30, 2026, 2:33 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Vaginal Natural Orifice Transluminal Endoscopic (vNOTE) Hysterectomy With Uterosacral Suspension

NCT07413861
View directory record Official record
Conditions
Prolapse Pelvic, Hysterectomy
Interventions
Uterosacral suspension, Hysterectomy by vNOTES approach
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 30, 2026, 2:33 AM EDT
Completed No phase listed Observational

Evaluation of the Relationship Between Vaginal and Lower Urinary Tract Microbiomes and Infection After Hysterectomy

NCT02751073
View directory record Official record
Conditions
Pelvic Organ Prolapse, Hysterectomy, Urinary Tract Infection
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years and older · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Not applicable Interventional

A Novel Tapered Applicator for Vaginal Vault Brachytherapy

NCT04318340
View directory record Official record
Conditions
Endometrial Cancer, Brachytherapy, Quality of Life
Interventions
Tapered applicator, Standard applicator
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 14, 2023 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Not applicable Interventional

The Effect of Vertical Versus Horizontal Vaginal Cuff Closure on Vaginal Length After Laparoscopic Hysterectomy

NCT02276261
View directory record Official record
Conditions
Hysterectomy
Interventions
Vaginal cuff closure - vertical, Vaginal cuff closure - horizontal
Procedure
Lead sponsor
Bridgeport Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Bridgeport, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 20, 2016 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Not applicable Interventional

A Randomized Trial Comparing Horizontal and Vertical Vaginal Cuff Closure

NCT02117492
View directory record Official record
Conditions
Hysterectomy
Interventions
Cuff Closure
Procedure
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2017 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Phase 1 Interventional

Pelvic IMRT With Tomotherapy in Post-Hysterectomy Endometrial Cancer Patients

NCT00334321
View directory record Official record
Conditions
Endometrial Cancer
Interventions
IMRT, Intracavitary vaginal brachytherapy, Paclitaxel, Carboplatin
Radiation · Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Sep 30, 2026, 2:33 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy

NCT07842159
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Combined Bupivacaine and Exparel, Normal Saline (NS)
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Sep 30, 2026, 2:33 AM EDT
Completed Not applicable Interventional

Laparoscopic Approach to Cervical Cancer

NCT00614211
View directory record Official record
Conditions
Cervical Cancer
Interventions
Total Abdominal Radical Hysterectomy, Total Laparoscopic or Robotic Radical Hysterectomy
Procedure
Lead sponsor
Queensland Centre for Gynaecological Cancer
Government
Eligibility
18 Years and older · Female only
Enrollment
636 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2022
U.S. locations
6
States / cities
Baltimore, Maryland • Las Vegas, Nevada • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Sep 30, 2026, 2:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Difference-In-Differences Analysis of New Persistent Opioid Use After Surgery

NCT04805229
View directory record Official record
Conditions
Opioid Use
Interventions
Retrospective analysis of opioid use after surgery
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
30,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Sep 30, 2026, 2:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

NCT00005095
View directory record Official record
Conditions
Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Hereditary Breast/Ovarian Cancer (brca1, brca2), Ovarian Cancer, Sarcoma, Uterine Leiomyomata, Vaginal Cancer, Vulvar Cancer
Interventions
Ca-125, screening questionnaire administration, Surgery
Other · Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
6,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2040
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 28, 2025 · Synced Sep 30, 2026, 2:33 AM EDT