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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Vaginal pessary Clear all
Completed Phase 3 Interventional Results available

A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix

NCT02518594
View directory record Official record
Conditions
Short Cervical Length
Interventions
Vaginal progesterone, Placebo, Arabin Pessary
Drug · Device
Lead sponsor
The George Washington University Biostatistics Center
Other
Eligibility
Female only
Enrollment
1,311 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
16
States / cities
Birmingham, Alabama • San Francisco, California • Denver, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional

Vaginal Care System for Menopausal Women With Urinary Tract Infections

NCT05573334
View directory record Official record
Conditions
Urinary Tract Infections, Vaginal Flora Imbalance
Interventions
BioNourish
Device
Lead sponsor
Vaginal Biome Science
Other
Eligibility
Up to 89 Years · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional

A Study of Two Versions of the Uresta Pessary Handle for Women With Stress Urinary Incontinence

NCT07706491
View directory record Official record
Conditions
Stress Urinary Incontinence (SUI)
Interventions
pessary handle
Device
Lead sponsor
Resilia Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 8, 2026, 4:43 PM EDT
Withdrawn Phase 4 Interventional

Misoprostol in Office Hysteroscopy and Endometrial Biopsy

NCT03547778
View directory record Official record
Conditions
Office Hysteroscopy and Endometrial Biopsy
Interventions
Misoprostol 50 mcg pesssary, Placebos
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 70 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 17, 2021 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flourish Vaginal Care System to Establish Neovaginal Microbiome

NCT05372770
View directory record Official record
Conditions
Neovaginal Microbiome
Interventions
Flourish Vaginal Care system
Device
Lead sponsor
Vaginal Biome Science
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New Hope, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional Results available

Prevention of Preterm Birth With a Pessary in Twin Gestations

NCT02056639
View directory record Official record
Conditions
Premature Birth, Short Cervix
Interventions
Bioteque cup pessary
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2018 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Phase 2 Interventional Results available

Topical Anesthetic Use In Pessary Management

NCT02380742
View directory record Official record
Conditions
Pain
Interventions
lidocaine-prilocaine cream, Placebo cream
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional

A Single Group Study to Evaluate the Effects of a Boric Acid Suppository on Vaginal Health.

NCT06516757
View directory record Official record
Conditions
Vaginal Health, Bacterial Vaginosis
Interventions
Boric Acid Suppository
Dietary Supplement
Lead sponsor
Love Wellness
Industry
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2024 · Synced Sep 8, 2026, 4:43 PM EDT
Completed No phase listed Observational Results available

LIBERATE - PRO: Eclipse™ System Registry

NCT03028636
View directory record Official record
Conditions
Fecal Incontinence, Bowel Dysfunction, Bowel Incontinence, Accidental Bowel Leakage
Interventions
Not listed
Lead sponsor
Pelvalon, Inc.
Industry
Eligibility
19 Years and older · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Sunnyvale, California
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional Results available

A Pilot Clinical Study of the Efficacy and Safety of a Disposable Intravaginal Device for Stress Urinary Incontinence

NCT01762345
View directory record Official record
Conditions
Stress Urinary Incontinence
Interventions
pessary (disposable intra-vaginal device)
Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older · Female only
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chandler, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 23, 2016 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized, Double-blind, Placebo-controlled Trial Investigating the Role of a Personal Care Product on Vaginal Health

NCT05659745
View directory record Official record
Conditions
Vaginal Personal Care
Interventions
VM-02, Commercial Oral Probiotic Competitor, VM-02 Placebo
Other · Dietary Supplement
Lead sponsor
Seed Health
Industry
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Venice, California
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Sep 8, 2026, 4:43 PM EDT
Recruiting Phase 2 Interventional

Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)

NCT04098744
View directory record Official record
Conditions
CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia, HPV Related Disease
Interventions
Artesunate vaginal insert, Placebo vaginal insert
Drug
Lead sponsor
Frantz Viral Therapeutics, LLC
Industry
Eligibility
25 Years to 100 Years · Female only
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
7
States / cities
Fort Myers, Florida • Ann Arbor, Michigan • Cleveland, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional

Flourish HEC to Prevent Recurrence of BV

NCT05386147
View directory record Official record
Conditions
Bacterial Vaginosis
Interventions
Flourish HEC Vaginal Care System (contains a class II medical device plus other unregulated components)
Device
Lead sponsor
Vaginal Biome Science
Other
Eligibility
18 Years to 52 Years · Female only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rosemont, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 8, 2026, 4:43 PM EDT
Terminated Not applicable Interventional Results available

Pippa Pessary Study (Clinical Trial)

NCT05611970
View directory record Official record
Conditions
Stress Urinary Incontinence
Interventions
Vaginal pessary
Device
Lead sponsor
Liv Labs Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
3
States / cities
Chicago, Illinois • Lake Forest, Illinois • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 8, 2026, 4:43 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix

NCT02901626
View directory record Official record
Conditions
Short Cervix, Preterm Delivery
Interventions
Arabin Cervical Pessary
Device
Lead sponsor
The George Washington University Biostatistics Center
Other
Eligibility
Female only
Enrollment
544 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
12
States / cities
Birmingham, Alabama • Chicago, Illinois • New York, New York + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 8, 2026, 4:43 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Comparison of Absorption of Vaginal Diazepam Using Different Delivery Systems

NCT01696825
View directory record Official record
Conditions
Metabolism, Drug
Interventions
Diazepam tablet, 5 mg, vaginal, Diazepam Suppository, 5 mg, vaginal, Diazepam Cream, 5 mg, Vaginal
Drug
Lead sponsor
Jason Gilleran
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 15, 2014 · Synced Sep 8, 2026, 4:43 PM EDT
Completed No phase listed Observational

Host Response to Pessaries in Microbial Communities of the Postmenopausal Vagina

NCT02605135
View directory record Official record
Conditions
Stress Urinary Incontinence, Prolapse
Interventions
Continued Pessary Use
Device
Lead sponsor
Loyola University
Other
Eligibility
51 Years and older · Female only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 21, 2019 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Phase 4 Interventional Results available

Postoperative Belladonna and Morphine Suppositories in Vaginal Surgery

NCT01150474
View directory record Official record
Conditions
Vaginal Surgery
Interventions
Belladonna and Opium Suppositories, Placebo Suppositories
Drug
Lead sponsor
Kristina A. Butler
Other
Eligibility
18 Years and older · Female only
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 6, 2015 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional Results available

Prediction of Postsurgical Symptomatic Outcomes With Preoperative Pessary Use

NCT02680145
View directory record Official record
Conditions
Vaginal Vault Prolapse, Pelvic Organ Prolapse, Uterine Prolapse, Pelvic Floor Prolapse
Interventions
Preoperative Pessary Use
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Phase 2 Interventional Results available

Neo-Penotran Forte Vaginal Suppository for Vaginal Trichomoniasis

NCT01361048
View directory record Official record
Conditions
Trichomonas Vaginitis
Interventions
oral metronidazole, neo penotran forte, neo penotran forte once a day
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Sep 8, 2026, 4:43 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor

NCT01840228
View directory record Official record
Conditions
Premature Birth, Obstetric Labor, Premature
Interventions
Micronized progesterone suppository
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Sep 8, 2026, 4:43 PM EDT
Completed Not applicable Interventional

Timing of Pessary Care

NCT02371083
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Extended timing of pessary care
Other
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 8, 2026, 4:43 PM EDT
Terminated Phase 1 Interventional

Effects of Flourish HEC and BioGenesis to Improve Conception

NCT05390606
View directory record Official record
Conditions
Infertility, Infertility Unexplained
Interventions
Flourish HEC and BioGenesis
Combination Product
Lead sponsor
Vaginal Biome Science
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Ramon, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Sep 8, 2026, 4:43 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC)

NCT04349930
View directory record Official record
Conditions
Interstitial Cystitis, Bladder Pain Syndrome
Interventions
Cannabidiol vaginal suppository, Placebo vaginal suppository
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Sep 8, 2026, 4:43 PM EDT