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ClinicalTrials.gov public records Last synced Oct 14, 2026, 12:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 241–264 of 273 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Varenicline tartrate Clear all

Conditions: Smoking Cessation
Interventions: Removal of Financial Barriers, Financial Incentives, Mobile Health Application; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 3,228 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 5
States / cities: Oakland, California • Detroit, Michigan • Danville, Pennsylvania + 2 more

Conditions: Nicotine Dependence
Interventions: Varenicline, Placebo, Smoking Cessation Counseling; Drug · Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 179 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Reduction
Interventions: Varenicline Tartrate, Placebo, Electronic cigarette; Drug · Other
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Kansas City, Missouri

Conditions: Cocaine Dependence
Interventions: Varenicline; Drug
Lead sponsor: Jennifer Plebani; Other
Eligibility: 18 Years to 60 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: varenicline (CP-526,555); Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 730 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 6
States / cities: Palo Alto, California • Santa Ana, California • Farmington, Connecticut + 3 more

Conditions: Alcohol Use Disorder, Hiv, Tobacco Use Disorder
Interventions: Varenicline; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Smoking, HIV
Interventions: Varenicline, Positively Smoke Free, Placebo, Standard of Care; Drug · Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 184 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Dependence
Interventions: varenicline, placebo; Drug
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years to 60 Years
Enrollment: 163 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Dry Eye Disease
Interventions: Varenicline solution, Placebo nasal spray (OC-01 Vehicle Nasal Spray); Drug
Lead sponsor: Stephenson Eye Associates; Other
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Venice, Florida

Conditions: Smoking, HIV Infections
Interventions: Varenicline tartrate, Nicotine Replacement Therapy, Biological Control, Motivational Interview; Drug · Other · Behavioral
Lead sponsor: Philip Diaz; Other
Eligibility: 18 Years and older
Enrollment: 294 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cigarette Smoking
Interventions: contingency management, Standard of Care; Behavioral · Other
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Varenicline, Placebo pill; Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 64 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Smoking Cessation
Interventions: Aggressive Therapy; Other
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Staten Island, New York

Conditions: Smoking Cessation
Interventions: Bupropion, Nicotine patch, Varenicline; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 223 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Stanford, California

Conditions: Smoking Cessation, Stress, Sleep Disturbance, Nausea
Interventions: Varenicline Pill, Hydroxyzine Pill; Drug
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 19 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Human Immunodeficiency Virus, Smoking
Interventions: Bupropion, Varenicline, Cognitive Behavioral Therapy, Nicotine Replacement Therapy, Relapse Prevention Text Messaging; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cannabis Use Disorder
Interventions: Varenicline, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 174 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Charleston, South Carolina • Pickens, South Carolina

Conditions: Tobacco Use Disorder, Weight Gain
Interventions: Varenicline, Lorcaserin; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Cocaine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2019
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: Health Rewards, Control; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Smoking Cessation
Interventions: varenicline, placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 2
States / cities: Austin, Texas • San Antonio, Texas

Conditions: Smoking Cessation
Interventions: placebo, Varenicline Tartarate; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 35 Years and older
Enrollment: 504 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 22
States / cities: Birmingham, Alabama • Los Angeles, California • Denver, Colorado + 15 more

Conditions: Smoking Cessation, Opioid Related Disorders
Interventions: varenicline; Drug
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years and older
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Morgantown, West Virginia

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Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

Varenicline for Nicotine Dependence Among Those With HIV/AIDS

Switching to E-cigarettes in Smokers Not Interested in Quitting

Human Behavioral Pharmacology Laboratory Study of Varenicline's Impact on Cocaine Reinforcement

An Open Label Study That Compares Varenicline to Transdermal Nicotine Patch for Smoking Cessation

Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2

Optimizing Smoking Cessation for People With HIV/AIDS Who Smoke

Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement

Evaluation of Tear Film Quality and Stability in Subjects With Dry Eye Disease Using OC-01 (Varenicline Solution) Nasal Spray 0.03 mg as Compared to Vehicle Control Nasal Spray

Smoking Cessation Using Motivational Therapy and Varenicline

Effects of Varenicline on Brain Activity During Nicotine Abstinence

Contingency Management and Pharmacotherapy for Smoking Cessation

Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit

Comparison of Conservative and Aggressive Smoking Cessation Treatment Strategies in a Vascular Surgery Office Practice

Extended Treatment for Smoking Cessation

Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment

Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)

UH3 Varenicline for Cannabis Use Disorder

Lorcaserin for Preventing Weight Gain Among Smokers

A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence

Contingency Management to Promote Smoking Cessation: A Pilot Randomized Clinical Trial

Assessing Neuropsychiatric Symptoms Including Depression, Anxiety, Irritability, and Suicidal Thoughts or Behavior in Subjects Quitting Smoking on Varenicline Tartrate or Placebo

Smoking Cessation in Subjects With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD).

Smoking Cessation & Opioid Dependence Treatment Integration