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ClinicalTrials.gov public records Last synced Oct 6, 2026, 1:02 PM EDT

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Showing 25–48 of 273 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Varenicline tartrate Clear all
Terminated Early Phase 1 Interventional

Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

NCT02582008
View directory record Official record
Conditions
Current Smoker, Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma, Nasopharyngeal Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
Interventions
Bupropion Hydrochloride, Laboratory Biomarker Analysis, Nicotine Replacement, Quality-of-Life Assessment, Questionnaire Administration, Varenicline
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Improving Tobacco Treatment Rates for Cancer Patients Who Smoke

NCT04738643
View directory record Official record
Conditions
Cancer, Tobacco Use, Smoking, Nicotine Dependence
Interventions
Tobacco Use Treatment Service and Varenicline Management
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
Not listed
Enrollment
685 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 6, 2026, 1:02 PM EDT
Terminated Phase 2Phase 3 Interventional

Pilot Study of Varenicline (Chantix®) in the Treatment of Friedreich's Ataxia

NCT00803868
View directory record Official record
Conditions
Friedreich's Ataxia
Interventions
varenicline, placebo
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Tampa, Florida • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 24, 2012 · Synced Oct 6, 2026, 1:02 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Photorefractive Keratectomy (PRK)

NCT05045508
View directory record Official record
Conditions
Dry Eye
Interventions
OC-01 (varenicline 0.6mg/ml) nasal spray, Placebo (vehicle) Nasal Spray
Drug
Lead sponsor
Brandon Baartman
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Oct 6, 2026, 1:02 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Switching to E-cigarettes in Smokers Not Interested in Quitting

NCT05703672
View directory record Official record
Conditions
Smoking Reduction
Interventions
Varenicline Tartrate, Placebo, Electronic cigarette
Drug · Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 4 Interventional Results available

Nasal Spray Study in Sjogren's Dry Eye Disease

NCT05700422
View directory record Official record
Conditions
Sjogren's Syndrome, Dry Eye
Interventions
Varenicline Nasal Spray
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 4 Interventional Results available

Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary Care

NCT03670316
View directory record Official record
Conditions
HIV, AIDS, Smoking Cessation
Interventions
Algorithm Treatment, Quitline only
Drug · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
371 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Combining Varenicline and Guanfacine for Smoking Cessation

NCT04198116
View directory record Official record
Conditions
Smoking Cessation
Interventions
Varenicline, Guanfacine ER
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Laser-assisted in Situ Keratomileusis (LASIK)

NCT05082974
View directory record Official record
Conditions
Dry Eye Disease
Interventions
OC-01 (varenicline 0.6mg/ml) nasal spray, Placebo (vehicle) nasal spray
Drug
Lead sponsor
Vance Thompson Vision ND
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
West Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Human Laboratory Study of Varenicline for Alcohol Use Disorder

NCT03035708
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Varenicline, Placebo oral capsule
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
New Haven, Connecticut • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 23, 2019 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

NCT04798664
View directory record Official record
Conditions
Smoking Cessation
Interventions
Removal of Financial Barriers, Financial Incentives, Mobile Health Application
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
3,228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
5
States / cities
Oakland, California • Detroit, Michigan • Danville, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 6, 2026, 1:02 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treating Smokeless Tobacco Use in Rural Veterans

NCT02994082
View directory record Official record
Conditions
Smokeless Tobacco, Nicotine Dependence
Interventions
Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials
Behavioral · Drug
Lead sponsor
Mark Vander Weg
Federal
Eligibility
18 Years to 99 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 6, 2026, 1:02 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Conservative and Aggressive Smoking Cessation Treatment Strategies in a Vascular Surgery Office Practice

NCT01850589
View directory record Official record
Conditions
Smoking Cessation
Interventions
Aggressive Therapy
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Staten Island, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2015 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

EVarQuit: Extended Pre-quit Varenicline to Assist in Quitting Smoking

NCT03262662
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Varenicline, Brief smoking cessation counseling
Drug · Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 70 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 6, 2026, 1:02 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program

NCT04107857
View directory record Official record
Conditions
Smoking Cessation
Interventions
ELEVATE enhancement to electronic health record (EHR) to improve cessation counseling offer, ELEVATE enhancement to electronic health record (EHR) to improve smoking cessation medication offer, Data Driven Feedback reports
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
1,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 6, 2026, 1:02 PM EDT
Withdrawn Phase 2 Interventional

Assessing the Impact of Varenicline on Brain-Behavior Vulnerability

NCT00895557
View directory record Official record
Conditions
Varenicline and the Blunting of Cocaine Cues
Interventions
chantix
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 55 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Human Laboratory Study Of Varenicline in Smokers

NCT00709696
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Placebo, Varenicline
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 27, 2017 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Web-based Smoking Cessation Program for Tribal College Students

NCT02050308
View directory record Official record
Conditions
Smoking Cessation
Interventions
Internet-All Nations Breath of Life (I-ANBL), Honoring the Gift of Heart Health, Nicotine gum, Patch, or Lozenge or Zyban® or Chantix®
Other · Drug
Lead sponsor
Won Choi, PhD, MPH
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Kansas City, Kansas • Pablo, Montana
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Oct 6, 2026, 1:02 PM EDT
Terminated Phase 3 Interventional Results available

Varenicline and Alcohol in Inpatient Addictions Program (IAP)

NCT01169610
View directory record Official record
Conditions
Alcoholism, Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 6, 2026, 1:02 PM EDT
Recruiting Early Phase 1 Interventional

Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder

NCT06582888
View directory record Official record
Conditions
Nicotine Addiction, Craving
Interventions
Varenicline Tartrate, Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
22 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Not applicable Interventional

Contingency Management to Promote Smoking Cessation

NCT06456242
View directory record Official record
Conditions
Smoking Cessation
Interventions
CounsCM+MedCM (Health Rewards)
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Phase 2 Interventional

12 Week Evaluation of the Safety and Efficacy of 4 Dosing Strategies of CP-526,555 and Placebo for Smoking Cessation.

NCT00150254
View directory record Official record
Conditions
Smoking Cessation
Interventions
CP-526,555 (varenicline)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 65 Years
Enrollment
625 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
13
States / cities
Los Angeles, California • San Bernardino, California • Upland, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2007 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Menominee Stop Tobacco Abuse Renew Tradition Study

NCT01083654
View directory record Official record
Conditions
Smoking
Interventions
Standard Treatment Counseling, Culturally-Tailored Treatment
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Keshena, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 17, 2016 · Synced Oct 6, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Financial Incentives for Homeless Smokers: A Community-based RCT

NCT04445662
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Financial incentives, Varenicline, Tobacco coaching
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 6, 2026, 1:02 PM EDT