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ClinicalTrials.gov public records Last synced Oct 21, 2026, 7:09 AM EDT

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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Varnish Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fluoride Varnish for Treatment of White Spot Lesions

NCT01500187
View directory record Official record
Conditions
White Spot Lesions
Interventions
Vanish Varnish, Pediagel
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
12 Years to 16 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser

NCT02357979
View directory record Official record
Conditions
Dental Caries
Interventions
Laser, Fluoride
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 21, 2026, 7:09 AM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Povidone Iodine Efficacy Study

NCT05272254
View directory record Official record
Conditions
Early Childhood Caries
Interventions
10% povidone iodine + FV, Placebo +FV
Drug · Other
Lead sponsor
University of Rochester
Other
Eligibility
24 Months to 71 Months
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 21, 2026, 7:09 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project

NCT04556175
View directory record Official record
Conditions
Early Childhood Caries, Dental Caries
Interventions
Oral Health, Healthy Lifestyle
Behavioral
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Kykotsmovi, Arizona • Crow Agency, Montana
Source: ClinicalTrials.gov public record
Updated Aug 29, 2025 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dental Office Prevention Strategies for Children

NCT02004990
View directory record Official record
Conditions
Dental Plaque
Interventions
Single cleansing procedure of 10% Povidone Iodine
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
6 Years to 13 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 10, 2017 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects

NCT03196219
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2, Placebo
Drug
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Kalispell, Montana
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes

NCT01629290
View directory record Official record
Conditions
Dental Caries
Interventions
Enamel Pro, Duraphat, Vanish, Placebo
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 22, 2017 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Silver Diamine Fluoride Pilot Study (SDF)

NCT02591147
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride 38%, Group 2 (Placebo)
Device
Lead sponsor
Justine Kolker
Other
Eligibility
21 Years to 64 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Results available

Xylitol for Caries Prevention in Inner-City Children

NCT01901250
View directory record Official record
Conditions
Dental Caries
Interventions
Xylitol gummy bears, Sugar free fiber gummy bears, Oral health education, Fluoride varnish, Dental sealant
Dietary Supplement · Behavioral · Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
5 Years to 6 Years
Enrollment
562 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2014 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of Treatments to Prevent Dental Caries

NCT03448107
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
3,345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries

NCT01129440
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride Varnish, Glass Ionomer Sealant
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
2 Years to 3 Years
Enrollment
597 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
San Ysidro, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2020 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Caries Management by Risk Assessment in Children

NCT01310283
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol mints and fluoride varnish
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
5 Years to 9 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2012 · Synced Oct 21, 2026, 7:09 AM EDT
Active, not recruiting Not applicable Interventional

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

NCT07556367
View directory record Official record
Conditions
Head and Neck Cancer, Head and Neck Carcinoma, Head and Neck Neoplasms
Interventions
Surveys, Saliva Collection, Intra-oral photographs, Fluoride Varnish Treatment, Interview (Participant)
Other · Procedure · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of School-based Caries Prevention

NCT03442309
View directory record Official record
Conditions
Dental Caries, Quality of Life
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
7,418 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients

NCT04560478
View directory record Official record
Conditions
White Spot Lesion
Interventions
Pro Seal Sealant, MI Varnish
Device
Lead sponsor
Texas A&M University
Other
Eligibility
12 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Early Childhood Caries Prevention at a Pediatric Clinic

NCT00497029
View directory record Official record
Conditions
Dental Caries
Interventions
fluoride varnish, patient education
Drug · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
6 Months to 27 Months
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.

NCT01059058
View directory record Official record
Conditions
Tooth Demineralization
Interventions
MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care
Procedure
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 20 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 17, 2015 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children

NCT03294590
View directory record Official record
Conditions
Caries, Dental, Health Behavior
Interventions
OHT Parent targeted text messages, CWT Parent targeted text messages
Other
Lead sponsor
Boston University
Other
Eligibility
0 Months to 7 Years
Enrollment
754 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Oct 21, 2026, 7:09 AM EDT
Withdrawn Not applicable Interventional

Lesion Progression of Approximal Caries After Resin Infiltration

NCT02191943
View directory record Official record
Conditions
Proximal Caries
Interventions
Duraphat, Icon approximal caries infiltration kit
Device
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 26, 2015 · Synced Oct 21, 2026, 7:09 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Building Adaptive School-based Interventions for Caries

NCT07265830
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride (38%), Glass Ionomer Sealant, Fluoride Varnishes, Hygiene Intervention
Device · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
5 Years to 13 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Glenwood Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Orthodontic Varnish Microbiology Study

NCT04528134
View directory record Official record
Conditions
Dental Caries, Dental Plaque, Dental White Spot
Interventions
Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 27 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Results available

Resin Infiltration to Arrest Early Tooth Decay

NCT01584024
View directory record Official record
Conditions
Dental Caries
Interventions
Resin infiltration, Sham treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2019 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Fluoride Varnish Randomized Clinical Trial

NCT00066963
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride Varnish
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 36 Months
Enrollment
376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Oct 21, 2026, 7:09 AM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults

NCT04255251
View directory record Official record
Conditions
Caries Roots, Flouride Varnish, Caries; Dentin, Caries Arrested
Interventions
Silver Diammine Fluoride, Fluoride Varnishes
Drug
Lead sponsor
University of New England
Other
Eligibility
65 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 21, 2026, 7:09 AM EDT