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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:55 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 84 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Vascular Stiffness Clear all

Conditions: Cardiovascular Disease
Interventions: Respirable suspended particles (RSP) PM 2.5 dose of second-hand smoke; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 40 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Renal Insufficiency, Chronic
Interventions: Rilonacept, Placebo; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 80 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 2
States / cities: Aurora, Colorado • Nashville, Tennessee

Conditions: Acute Kidney Injury, Chronic Kidney Disease, Hypertension
Interventions: Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry, Pulse Wave Velocity, Gadolinium; Drug · Procedure
Lead sponsor: University of Florida; Other
Eligibility: 7 Years to 17 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Endothelial Function, Diabetes Mellitus, Hypertension
Interventions: carvedilol, metoprolol extended release; Drug
Lead sponsor: State University of New York - Downstate Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Pre-Eclampsia
Interventions: ARTSENS Pen; Device
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 18 Years and older · Female only
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cardiovascular Disease, Aging
Interventions: Exercise-Training Program; Behavioral
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 55 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Heart Failure, Congestive
Interventions: Not listed
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 55 Years to 85 Years
Enrollment: 579 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness
Interventions: Not listed
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years to 60 Years
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Hypertension
Interventions: Concord Grape Juice; Dietary Supplement
Lead sponsor: Boston University; Other
Eligibility: 21 Years to 75 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Blood Pressure
Interventions: Whey protein supplement, Carbohydrate supplement; Dietary Supplement
Lead sponsor: Syracuse University; Other
Eligibility: 60 Years to 85 Years
Enrollment: 99 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Vascular Health, Autonomic Function
Interventions: Endurance Exercise; Behavioral
Lead sponsor: University of Illinois at Urbana-Champaign; Other
Eligibility: 18 Years to 35 Years
Enrollment: 91 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Urbana, Illinois

Conditions: Pre-Eclampsia
Interventions: StO2 and EndoPAT; Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Patient Compliance
Interventions: Diet and Exercise Intervention; Other
Lead sponsor: Stanford University; Other
Eligibility: 10 Years to 19 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Fabry Disease
Interventions: Measures of arterial stiffness and endothelial function, Ambulatory blood pressure monitoring, Cardiopulmonary exercise testing (CPET), Serum and urine biomarkers; Diagnostic Test
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 8 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Congenital Heart Disease
Interventions: Treprostinil, Placebo; Drug
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Anxiety, Hypertension
Interventions: Clonidine Pill, Hydrochlorothiazide; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 79 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Arterial Stiffness, Healthy Lifestyle
Interventions: Delfi Personal Tourniquet Systems; Device
Lead sponsor: Salisbury University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Salisbury, Maryland

Conditions: Insulin Sensitivity, Endothelial Dysfunction, Blood Pressure
Interventions: High Load/Low Rep Resistance Training, Low Load/High Rep Resistance Training; Other
Lead sponsor: Arizona State University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Obesity
Interventions: Grape seed extract; Dietary Supplement
Lead sponsor: California Baptist University; Other
Eligibility: 18 Years to 29 Years · Male only
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Riverside, California

Conditions: Perimenopause
Interventions: Resistance Training Intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 40 Years to 60 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Atherosclerotic Cardiovascular Disease
Interventions: Coronary Artery Calcium Scan, Carotid Artery Ultrasound, Lipoprotein(a) Measurement, Vascular Function Testing; Diagnostic Test
Lead sponsor: St. Jude Children's Research Hospital; Other
Eligibility: 18 Years and older
Enrollment: 650 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension, Cognitive Decline
Interventions: Experimental: Nitrate-containing, Placebo: Nitrate-depleted; Drug
Lead sponsor: Gary L. Pierce, PhD; Other
Eligibility: 50 Years to 79 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Cardiovascular Diseases, HIV
Interventions: Not listed
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 337 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
Interventions: Salsalate, Placebo (for salsalate); Drug
Lead sponsor: Gary L. Pierce; Other
Eligibility: 18 Years to 79 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Iowa City, Iowa

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Dose-dependent Effects of Second-hand Smoke on Vascular Function

Interleukin-1 Trap to Treat Vascular Dysfunction in Chronic Kidney Disease (CKD)

Severe Sepsis in Children - IMPRESS-C

Coreg CR, Blood Vessel Stiffness and Blood Vessel Function

Prospective Case-Control Study of Cardiovascular Changes in Pregnancy Related Hypertensive Disorders

Effects of Age and Exercise on Blood Pressure Regulation

Using Magnetic Resonance Imaging to Predict People Who Are Likely to Develop Flash Pulmonary Edema (The PREDICT Study)

Vascular Function, Insulin Sensitivity, and Vitamin D

Blood Pressure Lowering Effects of Grape Juice

The Effect of Whey Protein Supplementation on Vascular and Cognitive Function in Older Adults

Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans

Utilization of Somatic Tissue Oxygen Saturation Monitoring in Pregnant Women

Vascular Health and Exercise Performance of Overweight Children

Cardiovasculorenal Phenotyping in Fabry Disease Through Noninvasive Testing

Acute Effects of Inhaled Treprostinil in Fontan Patients

Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System

Acute Effects of Autoregulated and Non-autoregulated Blood Flow Restrictive Bicep Curls

Resistance Training and Cardiometabolic Health

Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest

Hemodynamics After Resistance Training

Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE

Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

Arterial Elasticity: A Substudy of Strategic Timing of AntiRetroviral Treatment (START)

Targeting Inflammation to Treat Cardiovascular Aging