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Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Very Low Nicotine Cigarette Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use

NCT04084210
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch, Placebo Patch
Device · Other · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking and Ventricular Repolarization

NCT03916341
View directory record Official record
Conditions
Sudden Cardiac Death, Prolonged QTc Interval
Interventions
EC with nicotine, EC without nicotine, control, TC with nicotine (own brand), research TC with very low level nicotine
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Sep 21, 2026, 10:51 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

NCT03943706
View directory record Official record
Conditions
Tobacco Use
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 18, 2020 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

NCT02964182
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions
Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo
Drug · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

NCT04092387
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, E-Cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years to 44 Years · Female only
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

NCT05473585
View directory record Official record
Conditions
Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions
very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Results available

Correcting Public Misperceptions About Very Low Nicotine Content Cigarettes

NCT04974489
View directory record Official record
Conditions
Tobacco Use, Cigarette Use
Interventions
Emotion-based messages about the harm of VLNC, Continued-harm-framed messages about the harm of VLNC, Myth-refuting messages about the harm of VLNC, Control messages about littering
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

Very Low Nicotine Cigarettes in Smokers With Schizophrenia

NCT02019459
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Very low nicotine content cigarettes, standard nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 8, 2018 · Synced Sep 21, 2026, 10:51 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Cardiovascular Effects of Very Low Nicotine Content Cigarettes

NCT05707871
View directory record Official record
Conditions
Tobacco Use
Interventions
SPECTRUM cigarettes, usual brand of Cigarettes
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Phase 2 Interventional Results available

Randomized Trial to Evaluate the Effectiveness of X-22 as a Smoking Cessation Aid

NCT01400815
View directory record Official record
Conditions
Smoking Cessation
Interventions
X-22 Smoking Cessation Product, Active Control Cigarettes
Drug
Lead sponsor
22nd Century Limited, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
3
States / cities
Sacramento, California • Metairie, Louisiana • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2021 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Cigarettes, Smoking, and Chronic Pain

NCT05032755
View directory record Official record
Conditions
Chronic Pain, Smoking, Cigarette
Interventions
SPECTRUM NRC 102/103 investigational cigarettes, SPECTRUM NRC 600/601 investigational cigarettes
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

Very Low-Nicotine Cigarettes in Smokers With SUD

NCT01989507
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Sep 21, 2026, 10:51 AM EDT
Recruiting Not applicable Interventional

Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

NCT07161050
View directory record Official record
Conditions
Cigarette Smoking, E-cigarette Use
Interventions
Nicotine Content, Illegal cigarette price, E-cigarette price
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette Smoking Among Young Adults

NCT04340947
View directory record Official record
Conditions
Cigarette Smoking, Smoking Behaviors
Interventions
Very low nicotine cigarette: menthol, Very low nicotine cigarette: non-mentol
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 34 Years
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco

NCT03860077
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes, Uncomplicated
Interventions
Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Drug
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 21, 2026, 10:51 AM EDT
Recruiting Not applicable Interventional

Opioids, Low Nicotine Cigarettes, and Chronic Pain

NCT06747871
View directory record Official record
Conditions
Chronic Pain, Tobacco Use, Opioid Substitution Treatment
Interventions
Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC)
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

NCT02927847
View directory record Official record
Conditions
Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation, Supportive Counseling
Drug · Behavioral
Lead sponsor
Maggie M Sweitzer, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors

NCT02000921
View directory record Official record
Conditions
Tobacco Addiction, Dual Tobacco Use
Interventions
VLNC cigarettes, Combusted Products, Non-combusted products, CN cigarettes
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating New Nicotine Standards for Cigarettes - Project 3

NCT03194256
View directory record Official record
Conditions
Smoking, Cigarette, Electronic Cigarettes
Interventions
Spectrum Research Cigarettes
Behavioral
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 17, 2023 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

NCT03185546
View directory record Official record
Conditions
Smoking
Interventions
NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Results available

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

NCT03612960
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Very low nicotine content cigarettes, Normal nicotine content cigarettes
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)

NCT02538042
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (0.07 mg), MCE-
Drug · Behavioral
Lead sponsor
Francis McClernon, Ph.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Not applicable Interventional

Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes

NCT01681875
View directory record Official record
Conditions
Tobacco Dependence
Interventions
very low nicotine content cigarettes
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
839 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
9
States / cities
San Francisco, California • Tampa, Florida • Baltimore, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 21, 2026, 10:51 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Innovative Interventions for Smoking Cessation

NCT01050569
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
2
States / cities
Duluth, Minnesota • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 21, 2026, 10:51 AM EDT