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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:57 PM EST

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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Very low carbohydrate diet Clear all

Conditions: Cholesterol Metabolism, Ketone Metabolism
Interventions: Standard American diet, Very low carbohydrate diet; Other
Lead sponsor: Touro University, California; Other
Eligibility: 18 Years to 50 Years · Male only
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Vallejo, California

Conditions: Obesity, Appetite, Healthy Volunteers
Interventions: Not listed
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 50 Years · Male only
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Type1diabetes
Interventions: very low carbohydrate diet, standard carbohydrate diet; Other
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 40 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Diabetes Mellitus, Type 2
Interventions: Multicomponent online program, Breath meter, Text messages, Diet-appropriate foods and cookbooks; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Polycystic Ovary Syndrome
Interventions: diet and lifestyle program; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 21 Years to 40 Years · Female only
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Metabolic-dysfunction Associated Steatotic Liver Disease
Interventions: Essential Amino Acids Supplementation intervention, Low sugar diet; Drug · Other
Lead sponsor: Michigan State University; Other
Eligibility: 11 Years to 17 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Grand Rapids, Michigan

Conditions: Type 2 Diabetes
Interventions: Breakfast; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 80 Years
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: High Blood Pressure, Flow Mediated Dilation
Interventions: fruit and vegetable juice supplement, Placebo; Dietary Supplement
Lead sponsor: Arizona State University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Obesity, Insulin Resistance
Interventions: Metabolically abnormal obese - Mediterranean diet, Metabolically abnormal obese - Low carbohydrate ketogenic diet, Metabolically abnormal obese - Plant-based, very-low-fat diet, Annual Follow-up Visits; Other · Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Tobacco Use
Interventions: VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C); Other · Drug
Lead sponsor: 22nd Century Group, Inc.; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Type1diabetes, Low Carbohydrate Diet
Interventions: low carbohydrate diet, standard carbohydrate diet; Other
Lead sponsor: Yale University; Other
Eligibility: 12 Years to 21 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Obesity, Insulin Resistance
Interventions: Low glycemic index diet, Low fat diet, Very low carbohydrate diet; Other
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 40 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Schizophrenia, Bipolar Disorder
Interventions: Ketogenic diet; Other
Lead sponsor: Northern California Institute of Research and Education; Other
Eligibility: 18 Years to 65 Years
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Type 1 Diabetes
Interventions: Very Low Carbohydrate Diet; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 13 Years to 25 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Obesity
Interventions: Feeding Study; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 50 Years
Enrollment: 166 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Ashland, Massachusetts

Conditions: Type 1 Diabetes Mellitus, Diet Modification, Child, Only
Interventions: Low carbohydrate diet, Very low carbohydrate diet; Other
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: 2 Years to 11 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Endometrial Cancer
Interventions: Ketogenic Diet (KD), Standard Diet (SD); Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 8
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Diabetes Mellitus, Type 2
Interventions: diet and lifestyle program, positive affect informational materials, mindfulness informational materials, dietary tracking; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 21 Years to 70 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Polycystic Ovary
Interventions: DASH diet, Very low-carbohydrate diet; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 21 Years to 45 Years · Female only
Enrollment: 223 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Elevated Triglycerides, Systolic Hypertension, Insulin Resistance, Abdominal Obesity
Interventions: standard ADA diet, energy restricted very-low carbohydrate diet, low glycemic diet; Dietary Supplement
Lead sponsor: CAMC Health System; Other
Eligibility: 12 Years to 18 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Charleston, West Virginia

Conditions: Cancer, Breast Cancer, Colon Cancer, Cervical Cancer, Uterine Cancer, Ovarian Cancer
Interventions: Very low carbohydrate diet (approximately 20 grams per day); Behavioral
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 21 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: PreDiabetes
Interventions: Low-Carbohydrate Diabetes Prevention Program; Behavioral
Lead sponsor: VA Ann Arbor Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Very Low Birth Weight Infants
Interventions: Lactoferrin; Dietary Supplement
Lead sponsor: University of Virginia; Other
Eligibility: Up to 14 Days
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Charlottesville, Virginia

Conditions: Type1diabetes
Interventions: Very low carbohydrate diet, Standard carbohydrate diet; Other
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 40 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

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Investigating the Production of Lipoproteins and Acetyl-CoA During a Ketogenic Diet

Study of the Effect of a Very-Low-Carbohydrate Diet on Energy Expenditure

Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet

Web-Delivered Interventions for Blood Sugar Control for Individuals With Type 2 Diabetes

The University of Michigan PCOS Intervention Using Nutritional Ketosis

SMART Diets for MASLD

The Breakfast Study

Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure

Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health

Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes

Metabolic Changes Induced by a Very Low Carbohydrate Diet in Youth With Type 1 Diabetes

Popular Diets Study

Can Neural Network Instability in Schizophrenia be Improved With a Very Low Carbohydrate Ketogenic Diet?

Very Low Carbohydrate Diet as an Adjunctive Therapy for Youth Type 1 Diabetes

FB4 (Framingham, Boston, Bloomington, Birmingham, and Baylor)

Safety of Low and Very Low Carbohydrate Diets in Young Children With Type 1 Diabetes

A Study of Ketogenic Diet in Newly Diagnosed Overweight or Obese Endometrial Cancer Patients

Examination of Psychological Tools and Tracking in an Online Intervention for Type 2 Diabetes

The Supporting Understanding of PCOS Education and Research (SUPER) Study

A Pilot Study to Determine the Efficacy of a Low Carbohydrate Diet in Treatment of Adolescents With Metabolic Syndrome

The RECHARGE Low Carbohydrate Diet Trial for Metastatic Cancer

Low-Carbohydrate Diabetes Prevention Program Among Veterans With Prediabetes

Safety and Tolerability of Lactoferrin in Very Low Birth Weight Infants

Effects of Ketosis on Brain Function in Patients With T1DM