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ClinicalTrials.gov public records Last synced Oct 17, 2026, 10:29 PM EDT

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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Visual Analog Scale for Pain Clear all
Completed Early Phase 1 Interventional

Trial Comparing a Multi-Modal Pain Protocol With and Without Opioids Following Total Joint Arthroplasty

NCT03845881
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Oxycodone, Placebo Oral Tablet
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Oct 17, 2026, 10:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Sensitivity During Puberty

NCT05145595
View directory record Official record
Conditions
Pain
Interventions
Thermal Sensory Analyzer, Pressure Stimuli, Mechanical Stimuli, Pain Ratings, Thermal pain thresholds, Pressure pain thresholds (PPT), Mechanical temporal summation, Conditioned pain modulation (CPM) efficiency, Offset analgesia efficiency, Cold pain tolerance
Device · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
9 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Recruiting No phase listed Observational

Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors

NCT07479199
View directory record Official record
Conditions
Thoracic Neoplasms, Lumbar Neoplasm
Interventions
kyphoplasty with Osteocool
Procedure
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

NCT07095608
View directory record Official record
Conditions
Oral Cancer, Squamous Cell Carcinoma
Interventions
Pressure and stretch sensitivity testing
Behavioral
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 17, 2026, 10:29 PM EDT
Completed Phase 2 Interventional

Capsaicin to Control Pain Following Third Molar Extraction

NCT00008476
View directory record Official record
Conditions
Facial Pain
Interventions
Capsaicin
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 17, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

Continuous Subpleural Infusion of Bupivacaine

NCT01566838
View directory record Official record
Conditions
Postoperative Pain
Interventions
Subpleural pain catheter with infusion of 0.125% bupivacaine, Standard acute pain management
Drug
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 20, 2017 · Synced Oct 17, 2026, 10:29 PM EDT
Completed Phase 2 Interventional Results available

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients

NCT04752384
View directory record Official record
Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
Buprenorphine, Tramadol, Oral Mucositis (OM) Pain App
Drug · Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 17, 2026, 10:29 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Mixed-Methods Evaluation of Short-, Medium-, and Long-Term Outcomes Following Hip Treatment

NCT06891196
View directory record Official record
Conditions
Hip Dysplasia, Legg-Calvâe-Perthes Disease, Avascular Necrosis of Hip
Interventions
Long-term Follow-up Surveys
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pain Inhibition With Neuromuscular Electrical Stimulation

NCT05280522
View directory record Official record
Conditions
Healthy Participants
Interventions
Volitional Contractions (VOL), Neuromuscular Electrical Stimulation (NMES), Noxious Electrical Stimulation (NXES)
Other · Device
Lead sponsor
University of New England
Other
Eligibility
18 Years to 30 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Oct 17, 2026, 10:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above-Knee Amputees

NCT00686764
View directory record Official record
Conditions
Neuroma Amputation
Interventions
Observational
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 99 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 14, 2015 · Synced Oct 17, 2026, 10:29 PM EDT
Recruiting Not applicable Interventional

Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing

NCT06939686
View directory record Official record
Conditions
Diabetic Foot Ulcers (DFUs), Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)
Interventions
Miro3D Wound Matrix, Standard of Care (SOC)
Device · Other
Lead sponsor
Reprise Biomedical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Coconut Creek, Florida • Tamarac, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 17, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

Neuropathic Pain in Pregnancy

NCT02608463
View directory record Official record
Conditions
Pain, Pregnancy
Interventions
painDETECT Questionnaire, Pain Catastrophizing Scale, Pain Intensity Scale, Pain Interference Scale, Pain Behavior Scale, Beck Depression Inventory, Visual Analogue Scale, Patient's Global Impression of Change Scale & Clinical Global Impression-Global Improvement Scale, Transcranial Magnetic Stimulation
Behavioral · Device
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Oct 17, 2026, 10:29 PM EDT
Recruiting Not applicable Interventional

Opioid Tapering After Hospital Discharge: Testing an Intervention to Improve Post-operative Opioid Prescribing

NCT07510373
View directory record Official record
Conditions
Opioid Tapering
Interventions
Treatment as Usual (TAU), Telephonic Support (TS) Providers, DOTS Intervention
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Needlefree Lidocaine Application for Vulvar Biopsies

NCT07793552
View directory record Official record
Conditions
Vulvar Cancers, Vulva Neoplasm, Vulvar Dysplasia
Interventions
J-Tip, Lidocaine HCl 1%
Device · Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Office Based Transperineal Laser Ablation for Benign Prostatic Hyperplasia HYPERPLASIA

NCT04760483
View directory record Official record
Conditions
Male Urogenital Diseases, Genital Diseases, Male, Prostatic Disease, Prostatic Hyperplasia
Interventions
SoracteLite(TM) TPLA for BPH
Device
Lead sponsor
Urological Research Network, LLC
Other
Eligibility
40 Years to 85 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Hialeah, Florida
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 17, 2026, 10:29 PM EDT
Recruiting No phase listed Observational

Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence

NCT05172089
View directory record Official record
Conditions
Chronic Wounds, Biofilm Infection, Trans-epidermal Water Loss (TEWL), Diabetic Foot, Diabetic Foot Infection
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
405 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Tucson, Arizona • Cranberry Township, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Withdrawn Phase 1Phase 2 Interventional Accepts healthy volunteers

Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis

NCT05742763
View directory record Official record
Conditions
Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
Interventions
Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP
Combination Product
Lead sponsor
QC Kinetix LLC
Industry
Eligibility
50 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 17, 2026, 10:29 PM EDT
Enrolling by invitation No phase listed Observational

Cannulated Bone Bolt® Screw System Versus Standard Cannulated Screw System Fixation for Pelvic Fractures

NCT07209280
View directory record Official record
Conditions
Pain
Interventions
Cannulated Bone Bolt® Screw System, Standard Cannulated Screw System
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Completed No phase listed Observational

BraveNet Multi-Center Study on Integrative Medicine Treatment Approaches for Pain

NCT01186341
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
418 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
9
States / cities
La Jolla, California • San Francisco, California • Santa Monica, California + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 17, 2026, 10:29 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine

NCT05738213
View directory record Official record
Conditions
Migraine
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Pressure pain thresholds (PPT), Conditioned pain modulation (CPM) response, PedMIDAS (Pediatric Migraine Disability Assessment), Hormonal assessment, Pubertal status
Device · Behavioral · Diagnostic Test + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
11 Years to 15 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Not yet recruiting No phase listed Observational

Prospective Observational Study of Smartphone-Based AI Self-Monitoring During Non-Surgical Treatment for Thyroid Eye Disease (THYROSCOPE)

NCT07623993
View directory record Official record
Conditions
Thyroid Eye Disease (TED), Graves Ophthalmopathy, Thyroid Associated Ophthalmopathies
Interventions
Smartphone-based AI self-monitoring application (Glandy CAS/EXO/LID)
Device
Lead sponsor
THYROSCOPE INC.
Industry
Eligibility
22 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Embo Registry; National Registry for Artery Embolization

NCT06477965
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis, Knee, Osteoarthritis Thumb, Osteoarthritis Shoulder, Pain, Chronic, Tendonitis Elbow, Tendonitis Shoulder, Tendonitis;Achilles, Tenosynovitis
Interventions
Artery Embolization
Procedure
Lead sponsor
Vascular Solutions of North Carolina
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
2
States / cities
Cary, North Carolina • Winchester, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 28, 2024 · Synced Oct 17, 2026, 10:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Strain-Counterstrain Treatment of Piriformis Pain

NCT05023005
View directory record Official record
Conditions
Low Back Pain, Mechanical, Piriformis Syndrome, Somatic Dysfunction of Sacral Region (Finding)
Interventions
Strain-Counterstrain treatment of piriformis muscle
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 17, 2026, 10:29 PM EDT
Not listed No phase listed Observational

Quality of Life Assessment of Chronic Pancreatitis Endoscopic Interventions

NCT03632616
View directory record Official record
Conditions
Chronic Pancreatitis
Interventions
PANQOLI (quality of life instrument)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
500 participants
Timeline
2017 – 2026
U.S. locations
2
States / cities
Aurora, Colorado • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Oct 17, 2026, 10:29 PM EDT