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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: WAVEFRONT Optimized LASIK Clear all
Completed No phase listed Observational Accepts healthy volunteers

Wavefront-guided Versus Wavefront-optimized LASIK for Nearsightedness

NCT01138189
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Wavefront-guided LASIK, Wavefront-optimized LASIK
Procedure
Lead sponsor
Edward E. Manche
Other
Eligibility
21 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Contralateral Comparison of Three Excimer Laser Systems in Performing LASIK

NCT00821236
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Excimer Laser, AMO/VISX CustomVue™, LADARVision 4000 excimer laser
Device
Lead sponsor
Durrie Vision
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
Overland Park, Kansas • Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 28, 2013 · Synced Sep 3, 2026, 10:49 PM EDT
Recruiting Not applicable Interventional

Contoura With Phorcides Compared to Wavefront Optimized LASIK

NCT05486546
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Contoura with Phorcides, WaveLight Wavefront Optimized
Procedure · Device
Lead sponsor
Daniel Terveen
Other
Eligibility
21 Years to 38 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
4
States / cities
Bozeman, Montana • Omaha, Nebraska • Fargo, North Dakota + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optical Quality, Threshold Target Identification, and Military Target Task Performance After Advanced Keratorefractive Surgery

NCT01097525
View directory record Official record
Conditions
Myopia, Myopic Astigmatism
Interventions
WFG PRK, WFG LASIK, WFO PRK, WFO LASIK
Procedure
Lead sponsor
Fort Belvoir Community Hospital
Federal
Eligibility
21 Years to 55 Years
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 12, 2015 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Phase 4 Interventional

An Evaluation of Outcomes Following Wavefront Optimized or Wavefront Guided Lasik Procedure in Low to Moderate Myopic Patients

NCT01173198
View directory record Official record
Conditions
Myopia
Interventions
WAVEFRONT Optimized LASIK, WAVEFRONT GUIDED LASIK
Device
Lead sponsor
Innovative Medical
Industry
Eligibility
21 Years to 35 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 13, 2012 · Synced Sep 3, 2026, 10:49 PM EDT
Terminated Not applicable Interventional Results available

Topo-guided LASIK and Photorefractive Keratectomy vs Wavefront LASIK and Photorefractive Keratectomy

NCT03075176
View directory record Official record
Conditions
Surgery, Myopia
Interventions
Wavefront optimized LASIK, Wavefront optimized Photorefractive Keratectomy, Topography-guided LASIK, Topography-guided Photorefractive Keratectomy
Device
Lead sponsor
University of Utah
Other
Eligibility
21 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jul 16, 2023 · Synced Sep 3, 2026, 10:49 PM EDT
Active, not recruiting Not applicable Interventional

LASIK iDesign vs SMILE

NCT07126756
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
STAR S4 IR Excimer Laser System, VisuMax 400 Surgical Laser
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
21 Years to 50 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Visual Outcomes and Contrast Sensitivity After Myopic LASIK

NCT01746589
View directory record Official record
Conditions
Myopia
Interventions
bilateral myopic LASIK
Device
Lead sponsor
Daniel S. Durrie, MD
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2013 · Synced Sep 3, 2026, 10:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

CONTOURA vs WFO Ablation PRK & LASIK

NCT05037370
View directory record Official record
Conditions
Refractive Surgery
Interventions
Wave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
21 Years to 50 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Resolution Wavefront-guided vs. Wavefront Optimized LASIK

NCT02565537
View directory record Official record
Conditions
Nearsightedness, Astigmatism
Interventions
LASIK
Procedure
Lead sponsor
Stanford University
Other
Eligibility
21 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Not applicable Interventional Results available

Clinical Investigation of the WaveLight® EX500 Excimer Laser

NCT04805593
View directory record Official record
Conditions
Hyperopia, Hyperopic Astigmatism
Interventions
WaveLight EX500 excimer laser system, LASIK
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Overland Park, Kansas • Kansas City, Missouri • Greensboro, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Sep 3, 2026, 10:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Three-Phase Contralateral Comparison of Ray-Tracing Guided LASIK Versus Three Other Refractive Surgery Platforms to Correct Myopia or Myopia With Astigmatism

NCT07201298
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Ray-Tracing Guided LASIK, Keratorefractive Lenticule Extraction (KLEx), WaveFront Optimized LASIK, Topography Guided LASIK
Device
Lead sponsor
Hoopes Vision
Other
Eligibility
22 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Draper, Utah
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Sep 3, 2026, 10:49 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Multi Laser Platform Comparison Study for LASIK

NCT00770094
View directory record Official record
Conditions
Myopia, Astigmatism
Interventions
Excimer Lasers, Excimer Laser for the LASIK procedure, Excimer Laser for LASIK
Device
Lead sponsor
Durrie Vision
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Atlanta, Georgia • Edina, Minnesota • McLean, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 5, 2009 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of Fellow Eyes Undergoing LASIK or PRK With a Wavefront-guided Excimer Laser Versus a Wavefront-optimized Excimer Laser

NCT01135719
View directory record Official record
Conditions
Hyperopia, Myopia, Astigmatism
Interventions
LASIK and PRK
Procedure
Lead sponsor
Edward E. Manche
Other
Eligibility
21 Years to 60 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Sep 3, 2026, 10:49 PM EDT
Completed Not applicable Interventional

Measuring Outcomes of LASIK and EVO-ICL in Matched Populations

NCT06700460
View directory record Official record
Conditions
Myopia
Interventions
Laser-assisted in Situ Keratomileusis, Implantable Collamer Lens placement
Device
Lead sponsor
Vance Thompson Vision
Other
Eligibility
21 Years to 45 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
5
States / cities
Omaha, Nebraska • Cleveland, Ohio • Mt. Pleasant, South Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 3, 2026, 10:49 PM EDT