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ClinicalTrials.gov public records Last synced Sep 30, 2026, 8:37 AM EDT

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Showing 25–48 of 50 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Water Mouthwash Clear all
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Antiviral Efficacy and Acceptability of Mouth Rinses for Inactivation of COVID-19

NCT04748783
View directory record Official record
Conditions
COVID19, Coronavirus Infection, SARS CoV-2 Infection
Interventions
Water, Peroxyl, Periogard, Colgate Total Zero
Other · Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Sep 30, 2026, 8:37 AM EDT
Terminated Phase 2 Interventional Results available

Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19)

NCT04409873
View directory record Official record
Conditions
COVID-19, SARS-CoV 2, Severe Acute Respiratory Syndrome Coronavirus 2, Virus Disease, Coronavirus Infections, Pharyngeal Diseases
Interventions
Oral-B Mouth Sore mouthwash, Crest Pro-Health Multi-Protection mouthwash, CloSYS Ultra Sensitive Rinse mouthwash, Distilled water, Listerine Zero Mouthwash Product
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effect of a Commercial Cosmetic Mouth Rinse on Plaque Re-growth

NCT01122862
View directory record Official record
Conditions
Healthy Subjects
Interventions
0.12% chlorhexidine mouthrinse, Cosmetic mouthrinse, Sterile water
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 9, 2013 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses

NCT05601154
View directory record Official record
Conditions
Dental Caries
Interventions
Crest Cavity Protection toothpaste, Crest Cavity Protection toothpaste followed by Act Mint Fluoride Rinse, Colgate PreviDent 5000+ toothpaste, Colgate PreviDent 5000+ toothpaste followed by Act Mint Fluoride Rinse
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparing Over-the-counter Dry Mouth Remedies After Radiation

NCT00595933
View directory record Official record
Conditions
Xerostomia
Interventions
sugar-free chewing gum, chewing gum, mouth rinse, mouth spray
Other · Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
13 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 7, 2022 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Two-Week Study of an Anticavity Low pH Mouthwash

NCT06010758
View directory record Official record
Conditions
Healthy
Interventions
Listerine Experimental Mouthwash, Colgate Cavity Protection Toothpaste, Listerine Total Care Zero, Listerine Cool Mint Zero
Drug · Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 12, 2024 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 1Phase 2 Interventional

An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness

NCT01369589
View directory record Official record
Conditions
Xerostomia, Sjogren's Syndrome
Interventions
P-552, Placebo
Drug
Lead sponsor
Parion Sciences
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Astringency and Oral Health

NCT05819073
View directory record Official record
Conditions
Saliva Altered, Taste, Altered
Interventions
Plain water, CPE
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 28, 2025 · Synced Sep 30, 2026, 8:37 AM EDT
Terminated Phase 2 Interventional Results available

Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)

NCT01349192
View directory record Official record
Conditions
Cystic Fibrosis, Methicillin-resistant Staphylococcus Aureus
Interventions
Rifampin, Trimethoprim/Sulfamethoxazole, Minocycline, Mupirocin, chlorhexidine gluconate oral rinse, 2% Chlorhexidine solution wipes, Environmental Decontamination
Drug · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
4 Years to 45 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
13
States / cities
Birmingham, Alabama • Aurora, Colorado • Gainesville, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated May 15, 2017 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate Effects of Gargle Phonation in Voice

NCT04766658
View directory record Official record
Conditions
Voice Disorders, Muscle Tension Dysphonia, Speech Therapy
Interventions
Gargle Phonation, Water swallow
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Results available

Study of the Effects of Brilacidin Oral Rinse on Radiation-induced Oral Mucositis in Patients With Head and Neck Cancer

NCT02324335
View directory record Official record
Conditions
Head and Neck Neoplasms, Mucositis
Interventions
Brilacidin, Placebo
Drug · Other
Lead sponsor
Innovation Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
16
States / cities
Gilbert, Arizona • Lakeland, Florida • Columbus, Georgia + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms

NCT02641912
View directory record Official record
Conditions
Xerostomia
Interventions
Biotene mouthwash, Mineral Water
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Pilot Study to Assess Dry Mouth Relief After Using an Experimental Mouth Rinse

NCT04152642
View directory record Official record
Conditions
Dry Mouth
Interventions
Marketed Dry Mouth Rinse, Water control, Experimental Dry Mouth Rinse
Device · Other
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Mason, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Sep 30, 2026, 8:37 AM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate

NCT07664527
View directory record Official record
Conditions
Asthma
Interventions
Fluticasone Propionate, Water Mouthwash, EVOOW Mouthwash
Drug · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Sep 30, 2026, 8:37 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Stromal Vascular Fraction for Treatment of Xerostomia

NCT03061110
View directory record Official record
Conditions
Xerostomia Due to Radiotherapy (Disorder)
Interventions
Stromal Vascular Fraction, Usual Care
Biological · Other
Lead sponsor
Midwestern Regional Medical Center
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Zion, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 30, 2026, 8:37 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension

NCT03787082
View directory record Official record
Conditions
Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction, Pulmonary Heart Disease and Diseases of Pulmonary Circulation
Interventions
Nitrates, Chlorhexidine Gluconate Mouthwash, Placebo Mouthwash
Drug
Lead sponsor
Gladwin, Mark, MD
Individual
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2022 · Synced Sep 30, 2026, 8:37 AM EDT
Recruiting Not applicable Interventional

Oil Pulling Reduction

NCT07706647
View directory record Official record
Conditions
Good Health, Gingival Inflammation and Bleeding, Dental Plaque
Interventions
GuruNanda natural Oil Pulling oral rinse, TheraBreath Plaque Control Oral Rinse, GuruNanda water-based non-whitening mouthwash
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 30, 2026, 8:37 AM EDT
Not listed Not applicable Interventional

[COVID-19] Reduction of Sars-CoV-2 Oral Viral Load With Prophylactic Mouth Rinse

NCT04719208
View directory record Official record
Conditions
Covid19
Interventions
Water (E) Mouth rinse with the solution provided, Chlorhexidine gluconate (A) Mouth rinse with the solution provided, Hydrogen peroxide (B) Mouth rinse with the solution provided, Betadine (C) Mouth rinse with the solution provided, Alcohol mouthwash (Listerine) (D) Mouth rinse with the solution provided
Other
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.

NCT02651467
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5), Placebo Oral Rinse (0% w/w KOX 0ppm F, pH 4.5 )
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Twelve Week Study of Supervised Mouth Rinse and Flossing

NCT04696536
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Referenced Toothbrush, 5% Hydroalcohol Mouth Rinse, REACH Dental Floss, Alcohol-containing Essential Oil (AEO) Mouth Rinse (Listerine Cool Mint, marketed)
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Results available

Acalabrutinib With Bendamustine / Rituximab Followed by Cytarabine / Rituximab for Untreated Mantle Cell Lymphoma

NCT03623373
View directory record Official record
Conditions
Mantle Cell Lymphoma
Interventions
Bendamustine, Rituximab, Acalabrutinib, Cytarabine, Leukapheresis, Peripheral blood, Oral rinse, Bone marrow collection
Drug · Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study of Virtually Supervised Mouthwash and Interdental Brushes

NCT05756673
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, LISTERINE ZERO Alcohol Mouthwash COOL MINT, LISTERINE COOL MINT Antiseptic Mouthwash, TePe Original Interdental Brush
Drug · Device
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
292 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Twelve Week Study of Virtually Supervised Mouth Rinse and Flossing

NCT04750005
View directory record Official record
Conditions
Healthy
Interventions
Listerine Cool Mint, Colgate Cavity Protection Toothpaste, Reach Unflavored Waxed Dental Floss, American Dental Association (ADA) Ref Toothbrush
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years to 60 Years
Enrollment
209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Sep 30, 2026, 8:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study to Investigate Salivary Flow and Potential of Hydrogen (pH) Following Use of Essential-Oil Containing Mouthwashes

NCT06136455
View directory record Official record
Conditions
Healthy
Interventions
Listerine Clinical Solutions Teeth Strength, Listerine Total Care Zero Alcohol Mouthwash, Listerine Cool Mint Zero Alcohol Mouthwash, Colgate Cavity Protection Toothpaste
Drug · Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 3, 2024 · Synced Sep 30, 2026, 8:37 AM EDT