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Showing 1–24 of 52 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Water Spray Clear all
Completed Phase 4 Interventional Results available

Nicotine Administration and Post-operative Opioid Use With Bariatric Surgery

NCT01194089
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Nasal Nicotine Spray, Nasal Normal Saline Spray
Drug
Lead sponsor
Toby Weingarten
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Sep 3, 2026, 12:44 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Maintaining Lower Levels of Care Through Automated Perineal Hygiene

NCT03051321
View directory record Official record
Conditions
Incontinence, Dermatitis
Interventions
Wellness toilet system
Device
Lead sponsor
SchwabCare
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Rancho Palos Verdes, California • Garfield Heights, Ohio
Source: ClinicalTrials.gov public record
Updated May 29, 2018 · Synced Sep 3, 2026, 12:44 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effect of Novel Exhalational Delivery System With Fluticasone (EDS-FLU) on Eustachian Tube Dysfunction (ETD)

NCT05275686
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
Fluticasone Propionate 93 MCG/1 ACTUATION Nasal Spray, Placebo Nasal Spray
Drug · Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
4
States / cities
Los Angeles, California • Sacramento, California • Indianapolis, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 3, 2026, 12:44 AM EDT
Recruiting Phase 1 Interventional

Cryospray Therapy for Benign Airway Stenosis

NCT06085209
View directory record Official record
Conditions
Stenosis Trachea
Interventions
The truFreeze Spray Cryotherapy, Ballon dilation, Radial Incision
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Oxytocin and Learning for Teaching

NCT02393443
View directory record Official record
Conditions
Social Psychology
Interventions
Intranasal oxytocin, Intranasal placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 30 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 9, 2017 · Synced Sep 3, 2026, 12:44 AM EDT
Recruiting Phase 1 Interventional

MAD Study to Assess the Safety, Tolerability, PKs and Efficacy of YJ001 for Spray Use in Patients With DPNP

NCT06361108
View directory record Official record
Conditions
Diabetic Peripheral Neuropathic Pain
Interventions
YJ001 for Spray Use, Placebo of YJ001 for Spray Use
Drug
Lead sponsor
Zhejiang Hanmai Pharmaceutical Technology Co., Ltd.
Industry
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Fredericksburg, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 3, 2026, 12:44 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Neuro Biomarkers of Smoking Behavior

NCT03811951
View directory record Official record
Conditions
Smoking Cessation
Interventions
Novolin R
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years to 40 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Evaluating Relative Bioavailability of OC-01 (Varenicline) Nasal Spray as Compared to Orally Administered Varenicline

NCT04072146
View directory record Official record
Conditions
Healthy Subjects
Interventions
Vaenicline oral tablet 1 mg, then OC-01 (varenicline solution) nasal spray 0.12 mg, OC-01 (varenicline solution) nasal spray 0.12 mg then Varenicline oral tablet 1 mg
Drug
Lead sponsor
Oyster Point Pharma, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 22, 2022 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Exercise in Burn Survivors: Cooling Modalities

NCT04512976
View directory record Official record
Conditions
Burn Injury
Interventions
Control (no cooling modalities), Water Spray Only, Fan Only, Water Spray and Fan
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 4 Interventional Results available

A Study to Evaluate the Efficacy and Safety of a Leave-in Spray in Subjects With Head Lice Infestation

NCT05565820
View directory record Official record
Conditions
Pediculosis Capitis, Lice Infestations, Head Lice
Interventions
Vamousse Spray 'n' Go, Nix Creme Rinse Lice Treatment
Other · Drug
Lead sponsor
Alliance Pharmaceuticals
Industry
Eligibility
2 Years to 75 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Sep 3, 2026, 12:44 AM EDT
Active, not recruiting Not applicable Interventional

Cryospray Therapy Versus Standard of Care for Benign Airway Stenosis (CryoStasis)

NCT04996173
View directory record Official record
Conditions
Pulmonary Disease
Interventions
Spray cryotherapy, Ballon Dilation, Radial Incision
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
3
States / cities
Jackson, Mississippi • Nashville, Tennessee • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Not applicable Interventional

Cosmetic Study of AO+Mist in Improving the Appearance of Skin Afflicted With Keratosis Pilaris

NCT03243617
View directory record Official record
Conditions
Keratosis Pilaris
Interventions
Placebo, AO+Mist
Other
Lead sponsor
AOBiome LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 8, 2017 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Malaria: Relative Bioavailability and Food Effect of DSM265

NCT03637517
View directory record Official record
Conditions
Healthy Volunteers
Interventions
DSM265-TPGS 34% SDD, 400 mg fasted, DSM265-TPGS 34% SDD, 400 mg fed, DSM265 25% SDD, 400 mg fasted
Drug
Lead sponsor
Medicines for Malaria Venture
Other
Eligibility
18 Years to 55 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Grayslake, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2020 · Synced Sep 3, 2026, 12:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Heat Waves and the Elderly - Cooling Modalities

NCT05484739
View directory record Official record
Conditions
Aging, Hyperthermia
Interventions
Water Spray, Fan, Water Spray and Fan, Control
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 1 Interventional

Study of KCC Peptide Application in the Colon

NCT02156557
View directory record Official record
Conditions
Colon Polyps, Colorectal Cancer, Inflammatory Bowel Disease (IBD)
Interventions
Colon KCC Heptapeptide
Biological
Lead sponsor
Danielle Kim Turgeon
Other
Eligibility
18 Years to 100 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Not applicable Interventional

Effect of Smartphone Application on Reducing Localized Inflammation in Periodontal Maintenance Patients

NCT04546295
View directory record Official record
Conditions
Periodontal Inflammation
Interventions
Brushlink application, Water-flosser, Interproximal brush
Other
Lead sponsor
University of Nebraska
Other
Eligibility
40 Years to 85 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 1 Interventional

Treatment of Orthostatic Hypotension in Autonomic Failure

NCT00223691
View directory record Official record
Conditions
Autonomic Failure, Orthostatic Hypotension
Interventions
Atomoxetine, Acarbose, Pyridostigmine Bromide, Yohimbine, Midodrine HCl, placebo, Modafinil, Octreotide, water intake, Diphenhydramine Hydrochloride, Ranitidine HCL, Tranylcypromine, Ergotamine/ Caffeine, Celecoxib, Pseudoephedrine, Methylphenidate, Indomethacin, Ibuprofen, Oxymetazoline 0.05% nasal solution, Bovril, Acetazolamide, Rivastigmine tartrate, Carbidopa/levodopa, Inflatable abdominal binder, inflatable abdominal binder (sham)
Drug · Other · Dietary Supplement + 1 more
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 85 Years
Enrollment
389 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 3 Interventional Results available

Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA)

NCT01089647
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
budesonide and montelukast, Placebo
Drug
Lead sponsor
Romaker & Associates
Other
Eligibility
18 Years to 100 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 2, 2018 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Vapocoolant Spray Used Prior to Intravenous (IV) Insertions

NCT03054740
View directory record Official record
Conditions
Pain
Interventions
Gebauer Ethyl Chloride, Nature's Tears
Drug
Lead sponsor
Aultman Health Foundation
Other
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Sep 3, 2026, 12:44 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation

NCT04831398
View directory record Official record
Conditions
Healthy
Interventions
melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Norman, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of Peppermint Oil During Screening Colonoscopy to Improve Visibility

NCT03286764
View directory record Official record
Conditions
Enhancement of the ADR During Colonoscopy
Interventions
Peppermint Oil, Distilled water
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

NCT06366503
View directory record Official record
Conditions
Photoaging, Wrinkle, Skin Laxity
Interventions
Fractional Ablative CO2 Laser, Facial Cleanser, Facial Moisturizer, Sunscreen, Basic Ointment
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Blue Ash, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 3, 2026, 12:44 AM EDT
Not yet recruiting Phase 3 Interventional

ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3

NCT06716021
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Placebo, Etripamil
Drug
Lead sponsor
Milestone Pharmaceuticals Inc.
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
2
States / cities
Haddon Heights, New Jersey • Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 3, 2026, 12:44 AM EDT
Completed Phase 3 Interventional

Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure

NCT00665977
View directory record Official record
Conditions
Obstructive Sleep Apnea, Nasal Congestion, Sinus Congestion
Interventions
Thermosmart & placebo, Placebo Device & Nasacort, Placebo Arm
Drug · Device
Lead sponsor
Clayton Sleep Insititute
Industry
Eligibility
16 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 6, 2010 · Synced Sep 3, 2026, 12:44 AM EDT