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ClinicalTrials.gov public records Last synced Sep 12, 2026, 10:31 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Intervention: Weaning Clear all
Recruiting Phase 2 Interventional

Human Upper Extremity Allotransplantation

NCT01459107
View directory record Official record
Conditions
Amputation, Traumatic, Wounds and Injuries, Hand Injuries
Interventions
Deceased donor hand transplantation, Bone marrow cell-based therapy & single-drug immunosuppression.
Procedure · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 69 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2036
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Not applicable Interventional Results available

Fluid Responsiveness Evaluation in Sepsis-associated Hypotension

NCT02837731
View directory record Official record
Conditions
Sepsis, Hypotension
Interventions
Treatment Starling SV monitor
Device
Lead sponsor
Cheetah Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
11
States / cities
San Francisco, California • Denver, Colorado • Atlanta, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 12, 2026, 10:31 AM EDT
Recruiting Not applicable Interventional

Humidity in Incubators for Tiny Infants

NCT06399861
View directory record Official record
Conditions
Extremely Premature Infant
Interventions
Higher (90%) starting RH in the incubator with humidity supplementation stopped at day 10, Lower (70%) starting RH in the incubator with humidity supplementation stopped at day 10, Higher (90%) starting RH in the incubator with humidity supplementation stopped at day 28, Lower (70%) starting RH in the incubator with humidity supplementation stopped at day 28
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
0 Days to 1 Day
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
9
States / cities
Birmingham, Alabama • San Diego, California • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP

NCT01939067
View directory record Official record
Conditions
Respiratory Distress, Lung Injury
Interventions
Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Hours to 72 Hours
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Phase 3 Interventional Results available

Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

NCT02836899
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Nitric Oxide, Placebo
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Active, not recruiting Not applicable Interventional

Implementation of Neuro Lung Protective Ventilation

NCT03243539
View directory record Official record
Conditions
Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke, Cerebral Edema, Anoxic Brain Injury
Interventions
Lung Protective Ventilation
Procedure
Lead sponsor
Colin Grissom
Other
Eligibility
18 Years and older
Enrollment
728 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Terminated Not applicable Interventional

Esophageal Balloon Guided Weaning of the Morbidly Obese Patient

NCT02323009
View directory record Official record
Conditions
Morbid Obesity
Interventions
Esophageal Balloon, Cstat
Device · Other
Lead sponsor
East Carolina University
Other
Eligibility
19 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 22, 2014 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children

NCT03815019
View directory record Official record
Conditions
Feeding Behavior, Feeding Disorder of Infancy or Early Childhood
Interventions
Megestrol Acetate, iKanEat Behavioral Intervention
Drug · Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
9 Months to 108 Months
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
8
States / cities
San Diego, California • Orlando, Florida • Indianapolis, Indiana + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Sep 12, 2026, 10:31 AM EDT
Not listed No phase listed Observational

Use of a Predictive Analytics Algorithm to Optimize Weaning of Inotropes Following Pediatric Cardiac Surgery

NCT04600700
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Clinical Decision support system (CDSS) for inotrope weaning
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Day to 365 Days
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Sep 12, 2026, 10:31 AM EDT
Withdrawn No phase listed Observational

Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population

NCT01795196
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
1 Year to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Sep 12, 2026, 10:31 AM EDT
Recruiting Not applicable Interventional

Optimal Timing for Spontaneous Breathing Trials

NCT06561295
View directory record Official record
Conditions
Respiration, Artificial, Weaning
Interventions
Later Morning Timing of Spontaneous Breathing Trials
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years and older
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Phase 3 Interventional Results available

Blinded Trial of Buprenorphine or Morphine in the Treatment of the Neonatal Abstinence Syndrome

NCT01452789
View directory record Official record
Conditions
Neonatal Abstinence Syndrome
Interventions
sublingual buprenorphine, oral morphine
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
Not listed
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Phase 4 Interventional

Inhaled Nitric Oxide by Oxygen Hood in Neonates

NCT00732537
View directory record Official record
Conditions
Respiratory Failure, Infant, Persistent Fetal Circulation
Interventions
inhaled Nitric Oxide, Oxygen (>90% by hood) - standard therapy
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Hour to 1 Week
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 11, 2008 · Synced Sep 12, 2026, 10:31 AM EDT
Recruiting Phase 3 Interventional

Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm

NCT06281977
View directory record Official record
Conditions
Ventricular Tachycardia, Ventricular Arrhythmias, Ventricular Fibrillation, Recurrent Ventricular Tachycardia
Interventions
Dexmedetomidine, Normal saline
Drug
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Not yet recruiting Phase 2 Interventional

Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?

NCT07447739
View directory record Official record
Conditions
Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD)
Interventions
Betamethasone
Drug
Lead sponsor
Khang Nguyen
Other
Eligibility
Up to 28 Weeks
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Recruiting Not applicable Interventional

Clinical Decision Support Tool in PARDS Pilot Study

NCT04068012
View directory record Official record
Conditions
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
Interventions
Ventilator protocol
Other
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
1 Month to 18 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
6
States / cities
Chicago, Illinois • Indianapolis, Indiana • Hershey, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Phase 1 Interventional

Music Therapy for Patients Being Weaned From Mechanical Ventilation

NCT00178139
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Music Therapy
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Sep 12, 2026, 10:31 AM EDT
Terminated Not applicable Interventional

Weaning From Mechanical Ventilation Using Permissive Hypercarbia

NCT00357929
View directory record Official record
Conditions
Respiration, Artificial, Respiratory Distress Syndrome, Adult
Interventions
Permissive hypercarbia
Procedure
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Phase 3 Interventional Results available

Belatacept Therapy for the Failing Renal Allograft

NCT01921218
View directory record Official record
Conditions
Failing Renal Allograft
Interventions
Belatacept, Calcineurin inhibitor therapy, Mycophenolate mofetil, prednisone
Drug
Lead sponsor
Andrew B Adams
Other
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Sep 12, 2026, 10:31 AM EDT
Withdrawn No phase listed Observational

Electrocardiographic Autonomic Function Measures in Mechanically Ventilated Patients

NCT00844935
View directory record Official record
Conditions
Disorders of the Autonomic Nervous System, Cardiovascular Abnormalities, Respiratory Disorders
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2012 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility and Pilot Efficacy of Flash-heated Breast Milk to Reduce Maternal-to-Child-Transmission of HIV in Tanzania

NCT00523510
View directory record Official record
Conditions
HIV Infections
Interventions
Infant feeding counseling that includes Flash-heat
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older · Female only
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2012 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Phase 2Phase 3 Interventional

Myfortic vs. Cellcept in Kidney Transplant Recipients

NCT00533624
View directory record Official record
Conditions
End Stage Renal Disease
Interventions
Mycophenolate Sodium Delayed Release Tablets, Mycophenolate Mofetil
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 12, 2026, 10:31 AM EDT
Recruiting Phase 4 Interventional

Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

NCT05593055
View directory record Official record
Conditions
Hypertension, Left Ventricular Hypertrophy
Interventions
Eplerenone, Chlorthalidone, Potassium
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 12, 2026, 10:31 AM EDT
Completed Not applicable Interventional

Elemental Formula in Neonates Post Small Bowel Resection: Improved Weaning From Total Parenteral Nutrition?

NCT01891279
View directory record Official record
Conditions
Short Bowel Syndrome
Interventions
elemental formula Elecare®, partially hydrolyzed formula
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Up to 1 Year
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 6, 2021 · Synced Sep 12, 2026, 10:31 AM EDT