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ClinicalTrials.gov public records Last synced Oct 7, 2026, 9:57 PM EDT

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Showing 25–48 of 51 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Weight loss and aerobic exercise training Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients

NCT02835326
View directory record Official record
Conditions
Osteoarthritis
Interventions
Exercise and Dietary Weight Loss, Walk with Ease
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
50 Years and older
Enrollment
227 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Results available

Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE)

NCT03423238
View directory record Official record
Conditions
Obesity, Weight Loss, CHD - Coronary Heart Disease
Interventions
Exercise, Health Education, Exercise Compliance, Calorie-Restricted Diet, Behavioral Modification, Weight-Loss Compliance, Dietary Counseling
Other · Behavioral · Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
40 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss

NCT01452074
View directory record Official record
Conditions
Obesity
Interventions
Exercise Training, Weight Loss with continued Exercise Training
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Exercise, Milk Thistle, and Lactobacillus to Influence Plasma Bilirubin

NCT04717726
View directory record Official record
Conditions
Obesity
Interventions
Milk Thistle (MT), Lactobacillus Gasseri (LAC), Exercise (EX), Control (CON)
Dietary Supplement · Behavioral
Lead sponsor
Kyle Flack
Other
Eligibility
18 Years to 50 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects

NCT05653258
View directory record Official record
Conditions
Obesity, Healthy Lifestyle
Interventions
Lifestyle Intervention, Dasatinib 100 MG, Quercetin 1000mg, Placebo, Abdominal adipose tissue biopsy
Other · Drug · Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Weight Reduction Intervention for Breast Cancer Survivors

NCT00774371
View directory record Official record
Conditions
Breast Cancer
Interventions
Cognitive behavioral therapy CBT) for weight loss
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
253 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 7, 2026, 9:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Exercise-Induced Weight Loss on Energy Metabolism

NCT01775163
View directory record Official record
Conditions
Metabolism, Weight Loss
Interventions
Not listed
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 24, 2021 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional

Muscle and Movement With Anti-Obesity Medications

NCT06645470
View directory record Official record
Conditions
Obesity and Overweight
Interventions
Standard Medical Care (SMC), Monitoring Contacts, Aerobic Training, Resistance Training, Nutrition Education
Other · Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Effect of a Low-Calorie Diet and/or Exercise Program on Risk Factors for Developing Breast Cancer in Overweight or Obese Postmenopausal Women

NCT00470119
View directory record Official record
Conditions
Breast Cancer, Obesity, Weight Changes
Interventions
behavioral dietary intervention, Exercise intervention
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
50 Years to 75 Years · Female only
Enrollment
439 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 10, 2012 · Synced Oct 7, 2026, 9:57 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Influence of Aerobic Training and Weight Loss on Skeletal Muscle Inflammatory Markers and Muscle Protein Balance in Older Adults

NCT03743675
View directory record Official record
Conditions
Overweight and Obesity, Inflammation; Muscle, Sedentary Lifestyle
Interventions
Diet-Induced Weight Loss, Aerobic Exercise Training
Behavioral
Lead sponsor
Miami University
Other
Eligibility
58 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Oxford, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 16, 2018 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Evaluating the Effects Two Diets Combined With Exercise in Persons With Abdominal Obesity (The SHAPE5 Study)

NCT00990457
View directory record Official record
Conditions
Overweight, Obese, Sedentary, Abdominal Obesity
Interventions
Weight Loss Diets Plus Exercise
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
30 Years to 65 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aging, Lifestyle and Inflammation in Veterans Exercising

NCT00667030
View directory record Official record
Conditions
Inflammation, Aging, Metabolism, Exercise
Interventions
Weight loss and aerobic exercise training
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Exercise and Inflammation in the Elderly

NCT00753363
View directory record Official record
Conditions
Inflammation, Insulin Sensitivity
Interventions
Weight Loss, Aerobic Exercise Training
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 80 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Oct 7, 2026, 9:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Aerobic and Resistance Training on Abdominal Fat Loss

NCT03700827
View directory record Official record
Conditions
Obesity, Abdominal
Interventions
Resistance Training, Aerobic Training
Other
Lead sponsor
Southern Illinois University Edwardsville
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Edwardsville, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Calorie Reduction Or Surgery: Seeking Remission for Obesity And Diabetes

NCT01295229
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Obesity
Interventions
laparoscopic Roux-en-Y gastric bypass (RYGB) procedure, Lifestyle Intervention
Procedure · Behavioral
Lead sponsor
University of Washington
Other
Eligibility
25 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 31, 2016 · Synced Oct 7, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

DNA Methylation and Vascular Function

NCT03527420
View directory record Official record
Conditions
Obesity, Vascular Dysfunction
Interventions
Exercise training
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 50 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study)

NCT00928005
View directory record Official record
Conditions
Overweight, Obesity, Type 2 Diabetes, Prediabetes
Interventions
Weight loss diet, Weight loss diet plus exercise
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
30 Years to 65 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 7, 2026, 9:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neural Activation and Connectivity in Response to Exercise and Cognitive Training

NCT01603771
View directory record Official record
Conditions
Neural Connectivity
Interventions
Blood Oxygen Level Dependent (BOLD) functional magnetic imaging (fMRI)
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
55 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 3, 2014 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Intervention and Varying Physical Activity in Seniors

NCT01893684
View directory record Official record
Conditions
Obesity
Interventions
Exercise, Higher Protein Diet, Conventional Carbohydrate Diet
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
65 Years to 80 Years · Female only
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 7, 2017 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ENCORE: Exercise and Nutritional Interventions for Cardiovascular Health

NCT00571844
View directory record Official record
Conditions
Hypertension
Interventions
DASH diet, DASH diet plus Weight loss
Behavioral
Lead sponsor
Duke University
Other
Eligibility
35 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 14, 2014 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors

NCT04221750
View directory record Official record
Conditions
Frailty, Sarcopenic Obesity, Aging
Interventions
Lifestyle therapy, Metformin Hydrochloride, Placebo, Healthy Lifestyle
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Impact of Weight Loss on Physical Function

NCT02079051
View directory record Official record
Conditions
Obesity
Interventions
Moderate intensity weight loss, High intensity medical weight loss
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 9, 2018 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Dyad Plus Effectiveness/Feasibility

NCT04036331
View directory record Official record
Conditions
Weight Loss, Pediatric Obesity, Overweight Adolescents, Parent-Child Relations, Family and Household
Interventions
Brenner FIT Standard, By Design Essentials, Dyad Plus
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
13 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 7, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Lifestyle Intervention for Senior Diabetics

NCT02348801
View directory record Official record
Conditions
Diabetes Mellitus, Aging, Overweight
Interventions
Weight loss and Exercise, Healthy lifestyle
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
65 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Oct 7, 2026, 9:57 PM EDT