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ClinicalTrials.gov public records Last synced Nov 5, 2026, 4:08 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 333 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Weight-Loss Maintenance Clear all

Conditions: Obesity
Interventions: Lifestyle intervention, Health education control, Individual, All Groups; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 75 Years
Enrollment: 631 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 14
States / cities: Bronson, Florida • Bunnell, Florida • Cross City, Florida + 11 more

Conditions: Obesity
Interventions: SHINE; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 194 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Obesity, Sedentary Lifestyle, Insulin Resistance
Interventions: Physical activity recommendations, Weight maintenance recommendations, OPTIFAST weight loss; Behavioral
Lead sponsor: East Carolina University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Greenville, North Carolina

Conditions: Insulin Resistance, Obesity
Interventions: Weight Maintenance, Weight Loss; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 21 Years to 65 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Obesity
Interventions: Enhanced NCP Support, LEAP; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 137 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Gestational Weight Gain, Obesity
Interventions: Weight Maintenance Group; Behavioral
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: San Luis Obispo, California • Baton Rouge, Louisiana

Conditions: Obesity, Depression
Interventions: vCare Intervention (6-month active treatment followed by 6-month maintenance), vCare Intervention (active treatment after 6 months); Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 50 Years to 74 Years
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Chicago, Illinois • St Louis, Missouri

Conditions: Pediatric Obesity
Interventions: Family-based treatment, Usual Care; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 6 Years and older
Enrollment: 1,010 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 4
States / cities: St Louis, Missouri • Buffalo, New York • Rochester, New York + 1 more

Conditions: Obesity
Interventions: Wellness-Centered (HUGS), Weight-Centered (LEARN); Behavioral
Lead sponsor: The Reading Hospital and Medical Center; Other
Eligibility: 30 Years to 45 Years · Female only
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: West Reading, Pennsylvania

Conditions: Obesity
Interventions: Behavioral weight loss intervention (Online; Rx Weight Loss), Minority stress intervention, Social support intervention, Negative body image intervention; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years to 70 Years · Female only
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Obesity, Weight Loss, Overweight
Interventions: Gold Standard Behavior Therapy for Weight Loss, Behavior Therapy for Weight Loss with Physical Activity Emphasis, Acceptance-based Behavior Therapy for Weight Loss with PA emphasis; Behavioral
Lead sponsor: Drexel University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Osteoarthritis
Interventions: Exercise and Dietary Weight Loss, Walk with Ease; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 50 Years and older
Enrollment: 227 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Diabetes, Weight Loss, Physical Function, Cognitive Function
Interventions: Lifestyle intervention, Diabetes Support Education; Behavioral
Lead sponsor: Wake Forest University; Other
Eligibility: 45 Years to 74 Years
Enrollment: 1,089 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 4
States / cities: Aurora, Colorado • Baton Rouge, Louisiana • Pittsburgh, Pennsylvania + 1 more

Conditions: Obesity Prevention, Weight Change, Weight Loss, Weight Loss Maintenance
Interventions: Reduced Food Variety (RFV), Home-based Resistance Training (HBRT), Buddy Training and Support (BTS), Acceptance and Commitment (ACT) Workshops; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 544 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Obesity
Interventions: Develop & Refine MOWI w/o Amulet, MOWI Weight Loss Maintenance, Develop & Refine MOWI w Fitbit, Develop & Refine MOWI w Fitbit/Protein; Behavioral · Dietary Supplement
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 65 Years and older
Enrollment: 69 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Overweight and Obesity
Interventions: SMART 2.0; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 35 Years
Enrollment: 638 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Obesity, Diabetes, Cardiovascular Disease
Interventions: Feeding study; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 234 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Framingham, Massachusetts

Conditions: Obesity
Interventions: Peer-Led Group Lifestyle Balance, Usual Care Services; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 314 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Cardiovascular Diseases, Cardiac Rehabilitation
Interventions: Text Messaging, Fully Automated Online Program, Low-Intensity Cardiac Rehabilitation Maintenance Program, High Intensity Cardiac Rehabilitation Maintenance Program; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Obesity
Interventions: Optifast Products; Dietary Supplement
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Obesity
Interventions: Saxenda®, Placebo; Drug · Other
Lead sponsor: Texas Tech University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Lubbock, Texas

Conditions: Obesity
Interventions: Coffee mannooligosaccharide, Coffee mannooligosaccharides; Dietary Supplement
Lead sponsor: Mondelēz International, Inc.; Industry
Eligibility: 20 Years to 65 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: New York, New York

Conditions: Obesity, Overweight, Weight Loss
Interventions: Behavior Therapy for Weight Loss, Behavior Therapy + Environment, Acceptance-based Behavior Therapy + Environment; Behavioral
Lead sponsor: Drexel University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 238 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Aging, Obesity
Interventions: Healthy Lifestyle Intervention, Lifestyle Intervention; Behavioral
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 65 Years to 85 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Houston, Texas

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Rural Lifestyle Eating and Activity Program (Rural LEAP)

Randomized Controlled Clinical Trial of Weight Loss Programs in Obese Persons

Exercise After Clinically Significant Weight Loss

Progressive Weight Loss and Metabolic Health

Learn, Engage, Act, Process (LEAP) for MOVE!

A Weight Maintenance Program Promoting Fat Loss in Pregnancy in Women With Obesity

Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

Primary Care Pediatrics Learning Activity and Nutrition With Families

Evaluation of a Health at Every Size vs a Behavioral Weight Loss Approach for Obese Women

Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women

Project Impact: An Innovative Approach to Weight Loss Maintenance

Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients

Physical and Cognitive Function - Look AHEAD Ancillary Study

Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance

MOWI Research Pilot

SMART 2.0: Social Mobile Approaches to Reducing weighT in Young Adults

Framingham State Food Study

Peer-Led Healthy Lifestyle Program in Supportive Housing

SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation

Improving Maintenance Following Very Low Calorie Diet: The Sustain Lost Weight (SLW) Intervention

To Predict Weight Loss Response to Liraglutide (Saxenda®), From fMRI-based Determination of Food Cue Reactivity

Study of Coffee Mannooligosaccharides for Weight Management

Environmental and Acceptance-Based Innovations for Weight Loss Maintenance

Lifestyle Intervention to Improve Bone Quality