Independent directory Public ClinicalTrials.gov records United States
Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 12, 2026, 12:06 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
Conditions
Dentin Hypersensitivity
Interventions
Test Toothpaste 1, Test Toothpaste 2, Reference Toothpaste
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Conditions
Tooth Discoloration, Periodontal Diseases
Interventions
Gum health formulation in intra-oral device, Gum health formulation on toothbrush
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Conditions
Health Adult Subjects
Interventions
Beaming White, Philips Zoom Professional Whitening Treatment, Opalescence Boost PF, Fluoride Toothpaste, Soft Manual Toothbrush, CP LED, Gingival Barrier
Drug · Combination Product · Device
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Melbourne, Florida
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal

NCT02151058
Conditions
Tooth Stain
Interventions
Colgate® Regular Cavity Protection, Experimental Mouth Rinse, Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint
Drug · Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years to 65 Years
Enrollment
227 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Fort Wayne, Indiana
Conditions
Tooth Discoloration
Interventions
Whitening Toothpaste, Experimental Mouthwash, Regular Fluoride Toothpaste
Drug · Device
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Melbourne, Florida
Conditions
Tooth Whitening, Tooth Discoloration
Interventions
Vitamin C toothpaste, Matching placebo
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Melbourne, Florida
Conditions
Teeth Staining
Interventions
Toothpaste
Other
Lead sponsor
Boka LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Effects of Three Oral Care Regimens

NCT02940821
Conditions
Dental Plaque, Gingivitis
Interventions
Toothbrushing, Fluoridated Dentifrice (.15% sodium monofluorophosphate), Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide), Whitening (4.5% hydrogen peroxide), Other Fluoridated Dentifrice (.454% stannous fluoride)
Other
Lead sponsor
Pearl Network
Network
Eligibility
18 Years to 70 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Emerson, New Jersey
Conditions
Gingival Diseases
Interventions
Fluoride, Triclosan/Fluoride toothpaste, antibacterial plant extract
Drug · Other
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Rochester, New York
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Study to Evaluate the Tooth Whitening Efficacy

NCT06957249
Conditions
Whitening
Interventions
Optic White 5%HP ActivShine Toothpaste, Crest3DWhite Advanced Radiant Mint Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Melbourne, Florida
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test Toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Noblesville, Indiana
Completed Phase 3 Interventional Accepts healthy volunteers

Dentinal Hypersensitivity Reduction

NCT06244290
Conditions
Dentinal Hypersensitivity
Interventions
Colgate SNF, Sensodyne Extra Whitening, Colgate Fluoride (CDC)
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Costa Mesa, California
Conditions
Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
Interventions
Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Conditions
Teeth Staining
Interventions
Toothpaste
Other
Lead sponsor
Boka LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Conditions
Stain Removal Efficacy
Interventions
Whitening Test Dentifrice (Code 826), Control dentifrice (Code 378)
Other
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Study to Compare Dental Plaque Control

NCT00758394
Conditions
Dental Plaque
Interventions
Fluoride, Triclosan/Fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 53 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
New York, New York