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Showing 1–24 of 1,256 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 3 Interventional

Discrete Hypothermia in the Management of Traumatic Brain Injury

NCT00676104
View directory record Official record
Conditions
Severe Traumatic Brain Injury
Interventions
CoolSystems Discrete Cerebral Hypothermia System
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 19, 2013 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Low-Dose Baclofen Administration on the GH-IGF1 Axis Study

NCT00871455
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Baclofen
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
20 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2011
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 1, 2012 · Synced Sep 3, 2026, 11:04 AM EDT
Terminated Not applicable Interventional Results available

Comparison of Virtual Reality and Passive Distraction on Burn Wound Care Pain in Adolescents

NCT01812655
View directory record Official record
Conditions
Burns, Wound Care, Pain
Interventions
Virtual Reality, Passive Distraction
Device · Other
Lead sponsor
University of Arkansas
Other
Eligibility
10 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Aug 5, 2013 · Synced Sep 3, 2026, 11:04 AM EDT
Recruiting Not applicable Interventional

Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury

NCT06734026
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Cafe Therapy
Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 3, 2026, 11:04 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Adult Trauma Centers RE-AIM at Gun Safety

NCT06302452
View directory record Official record
Conditions
Firearm Injury, Safety Issues
Interventions
Adopting Comprehensive Training for FireArm Safety in Trauma Centers
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
1,776 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
3
States / cities
Baltimore, Maryland • York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Not applicable Interventional Results available

Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury

NCT02878850
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Augmented Blood Pressure
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
11
States / cities
Los Angeles, California • New Haven, Connecticut • Kansas City, Kansas + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Problem Solving Training for Care Partners of Adults With Traumatic Brain Injury

NCT03739450
View directory record Official record
Conditions
Care Partners of Patients With Traumatic Brain Injury (TBI)
Interventions
Problem Solving Training (PST), Education
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
4
States / cities
East Hanover, New Jersey • Edison, New Jersey • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Sep 3, 2026, 11:04 AM EDT
Recruiting Not applicable Interventional

Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)

NCT05792189
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture, Koos Jr assesment on subjects with DFR of distal femur fracture
Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Phase 2 Interventional Results available

Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma

NCT02749968
View directory record Official record
Conditions
Blunt Chest Wall Trauma, Rib Fracture, Sternal Fracture
Interventions
Liposomal bupivacaine, 0.9% sodium chloride
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 3, 2022 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Not applicable Interventional Results available

Clinical Study to Compare 3 Multi-Layered Foam Dressings for the Management of Chronic Wounds

NCT03662997
View directory record Official record
Conditions
Chronic Wound, Venous Leg Ulcer, Diabetic Foot Ulcer
Interventions
Bordered Five-Layer Foam Dressing, Hydropolymer Foam Dressing, Hydrocellular Multi-Layer Foam Dressing
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
5
States / cities
Castro Valley, California • San Francisco, California • Newark, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Sep 3, 2026, 11:04 AM EDT
Terminated No phase listed Observational

Urinary KIM-1 After Vancomycin or Linezolid Administration

NCT02067390
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Not listed
Lead sponsor
Midwestern University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Sep 3, 2026, 11:04 AM EDT
Recruiting Phase 2 Interventional

Antibiotic Tumescent For Chronic Wounds

NCT06327113
View directory record Official record
Conditions
Non-healing Wound
Interventions
CeFAZolin Injectable Solution
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 3, 2026, 11:04 AM EDT
Terminated Phase 4 Interventional

ZYNRELEF for Pain Management in Total Knee Arthroplasty

NCT05644496
View directory record Official record
Conditions
Post Operative Pain, Osteoarthritis, Knee
Interventions
Bupivacaine-Meloxicam 400 Mg-12 Mg/14 mL Injectable Solution, Extended Release
Drug
Lead sponsor
Baptist Health South Florida
Other
Eligibility
35 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 3, 2026, 11:04 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord

NCT03990597
View directory record Official record
Conditions
Central Nervous System Sarcoma, Ependymoma, Glioma, Malignant Intracranial Germ Cell Tumor, Medulloblastoma, Pineoblastoma, Primary Central Nervous System Neoplasm
Interventions
Placebo Administration, Questionnaire Administration, Wound Dressing Material
Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
2 Years to 17 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Not applicable Interventional

Testing a Self-Management App for Symptoms of Posttraumatic Stress

NCT04155736
View directory record Official record
Conditions
PTSD
Interventions
Renew
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2021 · Synced Sep 3, 2026, 11:04 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)

NCT05846399
View directory record Official record
Conditions
Cat Bite, Hand Injuries, Arm Injury, Infection, Bacterial, Anti-bacterial Agents
Interventions
Amoxicillin/clavulanate, Ciprofloxacin, Clindamycin, Placebo (microcrystalline cellulose), Wound management
Drug · Other · Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 3, 2026, 11:04 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery

NCT00991328
View directory record Official record
Conditions
Post-Operative Delirium, Postoperative Cognitive Dysfunction
Interventions
SctO2 < 60 %.
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
65 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Phase 4 Interventional Results available

Zoledronic Acid Administration in Acute Spinal Cord Injury

NCT02042872
View directory record Official record
Conditions
Disuse Osteoporosis
Interventions
Zoledronic acid
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 49 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 13, 2018 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Phase 4 Interventional Results available

Pressure Ulcer Healing With Microcyn

NCT02001558
View directory record Official record
Conditions
Pressure Ulcer, Spinal Cord Injuries
Interventions
Microcyn, Sterile saline
Drug · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 5, 2018 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.

NCT02229578
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Sep 3, 2026, 11:04 AM EDT
Not yet recruiting Not applicable Interventional

Why Wait? Initiating Contingency Management in Traumatically Injured Patients During Hospitalization

NCT06931197
View directory record Official record
Conditions
Contingency Management, Methamphetamine Use Disorder
Interventions
Contingency management
Behavioral
Lead sponsor
Queen's Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 3, 2026, 11:04 AM EDT
Recruiting Phase 2 Interventional

Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)

NCT06706258
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Protonix (Pantoprazole) 40 mg q 12 hrs for 3 days, Pepcid (Famotidine) 20 mg q 12 hrs for 3 days
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 90 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Sep 3, 2026, 11:04 AM EDT
Completed Not applicable Interventional

APT001 Plasma/NO Generator to Treat Diabetic Foot Ulcer in Adults

NCT02356835
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
APT001, SHAM
Device
Lead sponsor
Origin Inc.
Industry
Eligibility
19 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
4
States / cities
Montgomery, Alabama • Fresno, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 3, 2026, 11:04 AM EDT
Recruiting Not applicable Interventional

Matrion Decellularized Placental Membrane Versus Conventional Wound Management in Subjects With Diabetic Foot Ulcers

NCT07116876
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Lower Extremity
Interventions
Graft Application, Wound Dressing Material
Other
Lead sponsor
LifeNet Health
Industry
Eligibility
21 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
18
States / cities
Tucson, Arizona • Castro Valley, California • Fresno, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 3, 2026, 11:04 AM EDT