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Showing 1–24 of 544 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: abstinence Clear all
Recruiting Not applicable Interventional

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

NCT04927143
View directory record Official record
Conditions
Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Interventions
App-Based Contingency Management, Sham Control
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oconomowoc, Wisconsin • Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 12, 2026, 10:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Functional Connectivity in Alcohol Use Disorder

NCT02877849
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
MRI: Brain Imaging data collection
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 5, 2019 · Synced Sep 12, 2026, 10:16 PM EDT
Active, not recruiting Phase 3 Interventional

Treating Polysubstance Use Using a Novel Digital Technology

NCT05766631
View directory record Official record
Conditions
Opioid Use, Opioid Use Disorder, Cocaine Use, Cocaine Use Disorder
Interventions
DynamiCare Health, Methadone Treatment-As-Usual
Behavioral · Drug
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
5
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

The Long-Term Treatment of Drug Addiction and Unemployment

NCT02487745
View directory record Official record
Conditions
Substance Abuse, Intravenous
Interventions
Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2022 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Phase 2 Interventional Results available

Targeting Anhedonia in Cocaine Use Disorder

NCT02773212
View directory record Official record
Conditions
Cocaine-Related Disorders, Anhedonia
Interventions
d-amphetamine, Contingency management, Placebo (for d-amphetamine)
Drug · Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 60 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 8, 2024 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Role of Low Lactose Infant Formula In The Management of Neonatal Abstinence Syndrome

NCT03549936
View directory record Official record
Conditions
Neonatal Abstinence Syndrome
Interventions
Low lactose or regular formula
Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
1 Minute to 7 Days
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Phase 1Phase 2 Interventional

Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence

NCT03015246
View directory record Official record
Conditions
Heroin Dependence, Opioid Use Disorder
Interventions
Extended release morphine, Buprenorphine/Naloxone low dose, Buprenorphine/Naloxone moderate dose, Buprenorphine/Naloxone high dose, Active stressor, Placebo stressor
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 55 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 9, 2020 · Synced Sep 12, 2026, 10:16 PM EDT
Recruiting Not applicable Interventional

Reset Challenge: Reducing High-risk Drinking for Cancer Prevention

NCT07591428
View directory record Official record
Conditions
Alcohol Drinking, Heavy Drinking, Binge Drinking
Interventions
30-Day Alcohol Abstinence Challenge
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 120 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 12, 2026, 10:16 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Using Telehealth to Address Alcohol Misuse in HIV Care

NCT04546971
View directory record Official record
Conditions
Alcohol Drinking, HIV Viremia
Interventions
Brief Intervention, Telehealth Counseling, Text messaging
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)

NCT00265564
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 12, 2026, 10:16 PM EDT
Not yet recruiting No phase listed Observational

Development of an Opioid Withdrawal Clinical Outcome Assessment

NCT07094672
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Not listed
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 12, 2026, 10:16 PM EDT
Terminated Phase 4 Interventional Results available

Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit

NCT02025855
View directory record Official record
Conditions
Opioid Use, Unspecified With Withdrawal, Opioid-Induced Disorders, Delirium
Interventions
Methadone, Placebo
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Sep 12, 2026, 10:16 PM EDT
Recruiting Not applicable Interventional

Digitally Rendered Interventions And Knowledge To Limit Ethanol-Associated Atrial Fibrillation Severity

NCT06995391
View directory record Official record
Conditions
Atrial Fibrillation (AF)
Interventions
Contemporary Guideline-Adherence, Alcohol Abstinence
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Sep 12, 2026, 10:16 PM EDT
Terminated Phase 2 Interventional Results available

Methadone Demonstration Project With Neonatal Intensive Care Unit Infants Diagnosed With Neonatal Abstinence Syndrome

NCT03134703
View directory record Official record
Conditions
Neonatal Abstinence Syndrome
Interventions
Methadone, Morphine
Drug
Lead sponsor
Johns Hopkins All Children's Hospital
Other
Eligibility
Up to 72 Hours
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 12, 2026, 10:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Quantification of Immune Cells in Women Using Contraception (CHIC II)

NCT01873170
View directory record Official record
Conditions
HIV, Immune Cells (Mucosal and Systemic), Contraception
Interventions
levonorgestrel exposure, DMPA exposure, etonogestrel exposure, IUD insertion, subdermal contraceptive implant insertion
Drug · Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 34 Years · Female only
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 26, 2021 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The S.A.F.E. Study : Computer-Aided Counseling to Prevent Teen Pregnancy/Sexually Transmitted Diseases (STDs)

NCT00151151
View directory record Official record
Conditions
Pregnancy, Sexually Transmitted Diseases
Interventions
Computer-Assisted Motivational Intervention, Didactic Educational Counseling
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 21 Years · Female only
Enrollment
660 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 12, 2011 · Synced Sep 12, 2026, 10:16 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior

NCT03840694
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Withdrawal
Interventions
Smoking Abstinence, Ad Lib Smoking
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls

NCT01214005
View directory record Official record
Conditions
Tobacco Use Disorder, Schizophrenia
Interventions
smoking abstinence
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 26, 2012 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Not applicable Interventional

Marijuana Treatment Project - 3

NCT00107588
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Reinforcement for homework completion, Reinforcement for Abstinence, Case Management
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 80 Years
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Sep 12, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobile Sensing of Smoking Behavior

NCT02116283
View directory record Official record
Conditions
Smoking, Health
Interventions
48 hour smoking abstinence, Smartphone
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 4, 2014 · Synced Sep 12, 2026, 10:16 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

NCT05522075
View directory record Official record
Conditions
Alcohol Drinking, Binge Drinking, Blood Pressure, Alcohol Abstinence, Aging, Lifestyle Factors, Vasodilation, Behavioral Problem
Interventions
Exercise Training, Alcohol Abstinence Intervention
Behavioral
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
50 Years to 64 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 12, 2026, 10:16 PM EDT
Not listed Not applicable Interventional

Harm Reduction Talking Circles for American Indians and Alaska Natives With Alcohol Use Disorders

NCT04267692
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
HaRTC
Other
Lead sponsor
Washington State University
Other
Eligibility
21 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Sep 12, 2026, 10:16 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women

NCT05303636
View directory record Official record
Conditions
Change in Bone Mineral Density, Bone Loss
Interventions
drospirenone 4 mg oral tablet or drospirenone 3.5 mg chewable tablet
Drug
Lead sponsor
Insud Pharma
Industry
Eligibility
14 Years to 45 Years · Female only
Enrollment
1,536 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
27
States / cities
Phoenix, Arizona • Aurora, Colorado • Boynton Beach, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 12, 2026, 10:16 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Phosphatidylethanol and Other Ethanol Consumption Markers

NCT06747364
View directory record Official record
Conditions
Healthy Volunteer, Alcohol Consumption
Interventions
Alcohol (Ethanol)
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
21 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Denton, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Sep 12, 2026, 10:16 PM EDT