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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:03 AM EST

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Showing 49–72 of 87 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: acetaminophen with codeine Clear all

Conditions: Surgery, Upper Extremity
Interventions: Toradol, Oxycodone; Drug
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pain
Interventions: Hydrocodone/Acetaminophen Extended Release, Acetaminophen, Morphine Extended Release, Placebo; Drug
Lead sponsor: AbbVie (prior sponsor, Abbott); Industry
Eligibility: 18 Years to 75 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 4
States / cities: Peoria, Arizona • Austin, Texas • San Marcos, Texas + 1 more

Conditions: Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use, Back Pain, Back Injuries, Chronic Pain, Chronic Low-back Pain, Pain, Chronic, Pain;Back Low;Chronic, Pain, Back
Interventions: Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cesarean Section Complications
Interventions: Ibuprofen, acetaminophen, oxycodone; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Neck Pain
Interventions: Chiropractic spinal manipulation, Acetaminophen, Self-care, Non-Steroidal anti-inflammatory drugs (NSAIDS), Tylenol with codeine; Procedure · Drug · Behavioral
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2007
U.S. locations: 1
States / cities: Bloomington, Minnesota

Conditions: Opioid Use Disorder
Interventions: Buprenorphine, Oxycodone; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 80 Years
Enrollment: 282 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: Ibuprofen 400 mg, Acetaminophen 650 mg, OxyCODONE 5 Mg Oral Tablet; Drug
Lead sponsor: University of Washington; Other
Eligibility: Not listed
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Chronic Low Back Pain
Interventions: hydrocodone/acetaminophen extended release, Placebo; Drug
Lead sponsor: AbbVie (prior sponsor, Abbott); Industry
Eligibility: 18 Years to 75 Years
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 17
States / cities: Tucson, Arizona • Anaheim, California • Burbank, California + 14 more

Conditions: Musculoskeletal Pain
Interventions: Acetaminophen, Oxycodone; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 393 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Post-operative Nausea, Post-operative Vomiting, Nausea Persistent
Interventions: Antiemetic anesthesia protocol; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 15 Years and older
Enrollment: 233 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Pain, Postoperative, ACL
Interventions: OxyCODONE 5 mg Oral Tablet, Naproxen 500 Mg, Tylenol Pill, Liposomal bupivacaine, Femoral Nerve Catheter; Drug · Procedure
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture
Interventions: Femoral Nerve Block, Adductor Nerve Block, No Block; Procedure · Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 75 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Pain
Interventions: 440 mg naproxen sodium with 1000 mg acetaminophen, 220 mg naproxen sodium with 650 mg acetaminophen, 10 mg hydrocodone + 650 mg acetaminophen, 440 mg naproxen sodium, Placebo tablet; Drug
Lead sponsor: Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division; Industry
Eligibility: 17 Years to 50 Years
Enrollment: 290 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid, Postoperative Pain, Acute Pain
Interventions: Suzetrigine, Acetaminophen, oxycodone; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: ACL Tear, Post Operative Pain
Interventions: Iovera, Celecoxib, Acetaminophen, Oxycodone, Tramadol, Bupivacaine Hydrochloride, Acetaminophen 500Mg Cap; Device · Drug
Lead sponsor: Matthew Varacallo; Other
Eligibility: 15 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: DuBois, Pennsylvania

Conditions: Sleep Apnea, Obstructive, Respiration Disorders
Interventions: supraglottoplasty with laser; Procedure
Lead sponsor: Indiana University; Other
Eligibility: 1 Year to 18 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2019
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Osteo Arthritis Knee
Interventions: Oxycodone, Tramadol, Tylenol, Meloxicam, Gabapentin, Metaxalone, Esomeprazole 20mg; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 216 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Disorder of Knee
Interventions: Oxycodone; Drug
Lead sponsor: International Clinical Research Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Pain
Interventions: Oxycodone/acetaminophen, Hydrocodone/acetaminophen, Codeine/acetaminophen, Ibuprofen/acetaminophen; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 416 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Pain Management, Opioid Consumption
Interventions: Placebo, Oxycodone 5 mg, Multimodal Non-Opioid Analgesia; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Head and Neck Cancer, Analgesia
Interventions: Tylenol, Oxycodone, Morphine, Gabapentin, toradol, Bupivacaine; Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Bone Metastases, Lymphoma, Multiple Myeloma, Opioid Use, Pain
Interventions: Ketorolac, Normal saline, Acetaminophen, Oxycodone Acetaminophen, Morphine, Hydrocodone/Acetaminophen, Oxycodone; Drug
Lead sponsor: St. Louis University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Pediatric Extremity Fracture, Pediatric Extremity Soft Tissue Injury
Interventions: Regional block, General Anesthesia, Local Anesthetic Ropivacaine, Opioids Morphine, Oral pain medication Acetaminophen with Hydrocodone; Procedure · Drug
Lead sponsor: University of Mississippi Medical Center; Other
Eligibility: 6 Years to 17 Years
Enrollment: 49 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Opioid Use
Interventions: Celecoxib, Acetaminophen, Pregabalin, Oxycodone, Percocet; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Search by objective public record fields.

Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

Towards Enhanced Recovery After Cesarean

Chiropractic Care, Medication, and Self-Care for Neck Pain

Examining Analgesic Synergy and Efficacy in Trauma Care

Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis

Phase 2 Chronic Low Back Pain Study

Acetaminophen (APAP) +/- Oxycodone

Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery

Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction

Factors Affecting the Speed of Recovery After ACL Reconstruction

Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study

Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management

Impact of Opioid Avoidance Protocol for ACL Reconstruction

Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty

The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty

Open-Label Study of Oxycodone/APAP to Treat Post-Operative Pain Following Arthroscopic Knee Surgery

Comparative Efficacy of 4 Oral Analgesics

Opioid-Sparing Joint Replacement

Multimodal Pain Study in Free Flap Patients

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Peripheral Nerve Blocks in Pediatric Orthopedic Patients

A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery