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Showing 1–24 of 1,297 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: arthroplasty Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

NCT05845021
View directory record Official record
Conditions
Osteoporosis, Arthroplasty Complications, Fragility Fracture
Interventions
Surgeon-Initiated Bone Health Referral Pathway
Combination Product
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 5, 2026, 4:42 AM EDT
Completed No phase listed Observational

Measuring Postoperative Mobility, Gait Symmetry and Feedback Following TJA

NCT03673293
View directory record Official record
Conditions
Total Joint Arthroplasty
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Sep 5, 2026, 4:42 AM EDT
Recruiting Not applicable Interventional

ARVIS TKA vs Conventional TKA

NCT06663384
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evaluation of Augmented Reality technology in TKA compared to standard TKA
Other
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 5, 2026, 4:42 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

CMP vs Fascia Iliaca Block

NCT04426058
View directory record Official record
Conditions
Pain, Postoperative, Hip Arthroplasty
Interventions
CMP, Fascia Illica
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Sep 5, 2026, 4:42 AM EDT
Not yet recruiting Not applicable Interventional

Using a Smart Implantable Device to Compare Early Recovery in Two Different Knee Arthroplasty Approaches

NCT07348835
View directory record Official record
Conditions
Total Knee Anthroplasty
Interventions
Total Knee Arthroplasty Medial Parapatellar Approach, Total Knee Arthroplasty Subvastus Approach
Procedure
Lead sponsor
Total Joint Specialists
Network
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sandy Springs, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 5, 2026, 4:42 AM EDT
Recruiting Phase 3 Interventional

Methadone in TKA for Post-op Pain and Opioid Reduction

NCT07226076
View directory record Official record
Conditions
Post Operative Pain
Interventions
Methadone Hydrochloride
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 5, 2026, 4:42 AM EDT
Completed Not applicable Interventional Results available

Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty

NCT05673720
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
active tDCS paired with active MBM, sham tDCS paired with sham MBM
Device
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 5, 2026, 4:42 AM EDT
Completed No phase listed Observational Results available

Survivorship and Outcomes of Robot Assisted Medial Partial Knee Replacement

NCT01845597
View directory record Official record
Conditions
Unicompartmental Knee Arthroplasty
Interventions
MAKOplasty® medial UKA
Procedure
Lead sponsor
Northwest Surgical Specialists, Vancouver
Other
Eligibility
21 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Sep 5, 2026, 4:42 AM EDT
Not listed Not applicable Interventional

A Prospective, Randomized, Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO) or Standard Care Dressings (AQUACEL Ag SURGICAL Dressing).

NCT03180346
View directory record Official record
Conditions
Surgical Incision
Interventions
PICO, Aquacel
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Sep 5, 2026, 4:42 AM EDT
Withdrawn Not applicable Interventional

Adductor Canal Nerve Block Following Total Knee Arthroplasty

NCT01939379
View directory record Official record
Conditions
Post-op Pain
Interventions
Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed., For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2021 · Synced Sep 5, 2026, 4:42 AM EDT
Completed Phase 4 Interventional Results available

Total Joint Arthroplasty and Sleep

NCT03968939
View directory record Official record
Conditions
Primary Total Hip Arthroplasty, Primary Total Knee Arthroplasty
Interventions
Diphenhydramine (Benadryl), Melatonin, Sleep Hygiene Education
Drug · Dietary Supplement · Behavioral
Lead sponsor
James A. Keeney
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Sep 5, 2026, 4:42 AM EDT
Active, not recruiting No phase listed Observational

Hospital for Special Surgery Hip Arthroplasty Cohort

NCT00454506
View directory record Official record
Conditions
Hip Arthroplasty
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 5, 2026, 4:42 AM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Safety and Efficacy of YM150 in Patients With Knee Replacement Surgery

NCT00595426
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
YM150, Warfarin
Drug
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
18 Years and older
Enrollment
685 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
44
States / cities
Mobile, Alabama • Phoenix, Arizona • Tuscon, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2013 · Synced Sep 5, 2026, 4:42 AM EDT
Completed Phase 4 Interventional Results available

Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty

NCT02839876
View directory record Official record
Conditions
Osteoarthritis, Acetaminophen, Arthroplasty, Hip Replacement
Interventions
Intravenous acetaminophen, Oral acetaminophen
Drug
Lead sponsor
Duke University
Other
Eligibility
56 Years to 85 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Sep 5, 2026, 4:42 AM EDT
Completed Phase 3 Interventional Results available

Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty

NCT02713178
View directory record Official record
Conditions
Pain
Interventions
bupivacaine liposome injectable suspension, Placebo
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
14
States / cities
Mobile, Alabama • Englewood, Colorado • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2020 · Synced Sep 5, 2026, 4:42 AM EDT
Completed No phase listed Observational Results available

Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty

NCT02276040
View directory record Official record
Conditions
Knee Pain Arthritis
Interventions
periarticular bupivicaine and liposomal bupivicaine
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 29, 2017 · Synced Sep 5, 2026, 4:42 AM EDT
Completed Not applicable Interventional

Suture Fixation System Versus Tendonous Reconstruction in Carpometacarpal (CMC) Arthroplasty

NCT01121874
View directory record Official record
Conditions
Thumb Carpometacarpal Arthritis
Interventions
Ligament reconstruction with suture fixation system, Ligament Reconstruction with Tendon Interposition (LRTI)
Procedure
Lead sponsor
J&M Shuler
Industry
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 5, 2026, 4:42 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Bilateral Total Knee Arthroplasty vs Unicompartment Arthroplasty Retrospective and Clinical Outcome Study

NCT02583113
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total and Unicompartment Knee Replacement
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Leesburg, Florida
Source: ClinicalTrials.gov public record
Updated Mar 19, 2023 · Synced Sep 5, 2026, 4:42 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers Results available

Opioid-Free Pain Protocol After Shoulder Arthroplasty

NCT05488847
View directory record Official record
Conditions
Shoulder Arthropathy, Shoulder Pain
Interventions
Celecoxib, Pregabalin, Tramadol, Dexamethasone, Acetaminophen, Ropivicaine, Epinephrine, Ketorolac, Tizanidine, Magnesium, Ibuprofen, Oxycodone Hydrochloride 5 Mg
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 5, 2026, 4:42 AM EDT
Completed Not applicable Interventional Results available

Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty

NCT02701296
View directory record Official record
Conditions
Posterior Knee Infiltration
Interventions
Ropivacaine with Epinephrine, Ropivacaine
Drug
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Sep 5, 2026, 4:42 AM EDT
Enrolling by invitation Not applicable Interventional

G7 Dual Mobility With Vivacit-E or Longevity PMCF

NCT05548972
View directory record Official record
Conditions
Hip Osteoarthritis, Rheumatoid Arthritis, Joint Diseases, Avascular Necrosis, Dislocation, Hip, Femoral Neck Fractures, Trochanteric Fractures, Revision Surgeries
Interventions
G7 Dual Mobility with Vivacit-E bearing, G7 Dual Mobility Longevity bearing
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 80 Years
Enrollment
358 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2037
U.S. locations
6
States / cities
Little Rock, Arkansas • Denver, Colorado • Jersey City, New Jersey + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Sep 5, 2026, 4:42 AM EDT
Terminated No phase listed Interventional Results available

Real-Time Instrument for Acetabular Shell Positioning

NCT02006251
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
Real-time Instrumentation, Standard Total Hip Arthroplasty
Device · Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 9, 2023 · Synced Sep 5, 2026, 4:42 AM EDT
Recruiting No phase listed Observational

A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System

NCT05653102
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Truliant Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2035
U.S. locations
5
States / cities
Aurora, Colorado • DeLand, Florida • Las Vegas, Nevada + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 5, 2026, 4:42 AM EDT
Active, not recruiting No phase listed Observational

Optetrak Knee System Post Market Clinical Follow-Up

NCT05788757
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Optetrak Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
4,588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2034
U.S. locations
3
States / cities
Worcester, Massachusetts • Las Vegas, Nevada • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 5, 2026, 4:42 AM EDT