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ClinicalTrials.gov public records Last synced Nov 5, 2026, 9:47 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 370 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: ascorbic acid (vitamin C) Clear all

Conditions: Femoral Fracture, Fragility Fracture, Muscle Atrophy
Interventions: Essential Amino Acid Supplementation; Combination Product
Lead sponsor: Michael C Willey; Other
Eligibility: 65 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Iowa City, Iowa • Eugene, Oregon

Conditions: Atrial Fibrillation, Atrial Flutter
Interventions: beta blockers, amiodarone, ascorbic acid; Drug
Lead sponsor: MaineHealth; Other
Eligibility: 18 Years and older
Enrollment: 304 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Portland, Maine

Conditions: Burns
Interventions: Intravenous Vitamin C, Vitamin C; Drug
Lead sponsor: United States Army Institute of Surgical Research; Federal
Eligibility: 18 Years to 72 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Fort Sam Houston, Texas

Conditions: Vitamin Deficiency
Interventions: EZPAK, Placebo; Dietary Supplement
Lead sponsor: Optimal Health Research; Other
Eligibility: 26 Years to 75 Years
Enrollment: 275 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Arteriovenous Fistula Occlusion
Interventions: Placebo, Ascorbic Acid, Cuprimine Oral Product; Drug
Lead sponsor: Southeast Renal Research Institute; Other
Eligibility: 18 Years to 90 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Chattanooga, Tennessee

Conditions: Intestinal Barrier Function
Interventions: Probiotic, Placebo; Dietary Supplement
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 50 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Type 2 Diabetes
Interventions: Exercise program, Ascorbic Acid (Vitamin C); Behavioral · Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 30 Years to 55 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Non-Hodgkin Lymphoma
Interventions: Intravenous vitamin C; Drug
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Anemia, Arthritis, Total Knee Arthroplasty, Total Hip Arthroplasty
Interventions: Conventional Oral TXA (Tranexamic Acid), Multi-Dose Oral TXA (Tranexamic Acid); Drug
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Obesity, Hyperlipidemia, Hypertension
Interventions: Antioxidant diet, Antioxidant supplement, Placebo; Behavioral · Dietary Supplement
Lead sponsor: Christopher Gardner; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Stanford, California

Conditions: Healthspan Improvement, Aging, Longevity
Interventions: Rapamycin, Naltrexone, Metformin, NAD+, GSH, Infinite Supplement, Placebo/control, B12, Intervention: Guided Meditation Program, Control: Podcast Listening Activity, Control: Standard Exercise Regimen, Intervention: Structured Exercise Program; Drug · Dietary Supplement · Behavioral
Lead sponsor: AgelessRx; Industry
Eligibility: 60 Years to 80 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Open Posterior Thoracolumbar Spinal Fusion Procedure
Interventions: Tranexamic Acid Injectable Product (1000 mg intravenous bolus), Vitamin C 250 MG Oral Tablet, Tranexamic Acid 650Mg Tablet; Drug
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 604 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Metastatic Pancreatic Cancer
Interventions: Gemcitabine and Erlotinib, Intravenous Vitamin C; Drug · Dietary Supplement
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Photodamaged Skin
Interventions: Vitamin C with AHA Exfoliative Serum, Placebo serum; Drug
Lead sponsor: Austin Institute for Clinical Research; Network
Eligibility: 30 Years to 65 Years · Female only
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Pflugerville, Texas

Conditions: Pancreatic Neoplasms, Cancer of Pancreas, Cancer of the Pancreas, Neoplasms, Pancreatic, Pancreas Cancer, Pancreas Neoplasms, Adenocarcinoma
Interventions: Gemcitabine, nab-paclitaxel, Pharmacological ascorbate; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Metastatic Pancreatic Cancer, Pancreatic Cancer, Pancreas Cancer, Pancreatic Adenocarcinoma Resectable, Pancreatic Ductal Adenocarcinoma, Pancreatic Metastasis
Interventions: Ascorbic Acid, Paclitaxel protein-bound, Cisplatin, Gemcitabine; Drug
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 6
States / cities: Scottsdale, Arizona • San Diego, California • Atlanta, Georgia + 3 more

Conditions: Pancreatic Neoplasms
Interventions: Ascorbate, Gemcitabine, Radiation therapy; Drug · Radiation
Lead sponsor: Joseph J. Cullen; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2025
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Myelodysplastic Syndromes and Leukemia, Myeloid, Acute
Interventions: Arsenic Trioxide, Decitabine; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Dietary Supplements
Interventions: Emergen-C Core Super Orange Powder, Placebo; Dietary Supplement
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 299 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Hypertension, Elevated Blood Pressure
Interventions: Vascanox® HP; Dietary Supplement
Lead sponsor: Calroy Health Sciences; Industry
Eligibility: 25 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Dietary Supplements, Connective Tissue, Exercise
Interventions: Natural Product Supplement, Placebo control; Dietary Supplement
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years to 30 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Davis, California

Conditions: Healthy, Suboptimal Vitamin C Levels, Adequate Vitamin C Levels
Interventions: Qualia Vitamin C+, Placebo; Dietary Supplement · Other
Lead sponsor: Qualia Life Sciences; Industry
Eligibility: 25 Years to 75 Years
Enrollment: 152 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Carlsbad, California

Conditions: Metabolic Syndrome, Overweight
Interventions: wheat-safflower oil pretzels, soy-safflower oil pretzels, control wheat pretzels; Other
Lead sponsor: Ohio State University; Other
Eligibility: 45 Years to 70 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Kidney Stone
Interventions: controlled diet; Dietary Supplement
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 60 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Birmingham, Alabama

Search by objective public record fields.

Essential Amino Acid Supplementation for Femoral Fragility Fractures

Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery

The Effect of High Dose Vitamin C in Burn Patients

Effectiveness of a Nutraceutical in Raising Circulating Serum Vitamin, Mineral and Amino Acid Levels in Patients.

Delivery of Inhibitors of Lysyl Oxidase (LysoLox) on Serial Angioplasty and Time to Restenosis

The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults

Influence of Endothelial Function on Central and Peripheral Causes Of Exercise Impairment in Type 2 Diabetes

Pilot Trial of Intravenous Vitamin C in Refractory Non-Hodgkin Lymphoma (NHL)

Single Versus Multi-Dose Oral Tranexamic Acid in Patients at High Risk for Blood Transfusion After Total Joint Arthroplasty

Effects of Dietary Antioxidants on Cardiovascular Risk Factors

Combination Gerotherapeutic Interventions for Healthspan Improvement

Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid Patients at High Risk for Blood Transfusion After Spine Surgery

Intravenous Vitamin C in Combination With Standard Chemotherapy for Pancreatic Cancer

Placebo-Controlled Study Assessing the Use of a Novel Exfoliative Serum With A Chemical Peel to Improve Photodamage in Adults

A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1)

High Dose Ascorbic Acid and Nanoparticle Paclitaxel Protein Bound and Cisplatin and Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer

Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I

Decitabine, Arsenic Trioxide and Ascorbic Acid for Myelodysplastic Syndromes and Acute Myeloid Leukemia

A Study Evaluating Quality of Life Parameters Following Use of Emergen-C

Open Label Clinical Trial of Vascanox® HP on Nitric Oxide and Blood Pressure

Developing a Nutritional Supplement to Increase Collagen Synthesis in People

The Impact of Qualia Vitamin C+ on Individuals With Suboptimal and Adequate Vitamin C Levels

Functional Snack Foods With Safflower Oil and Soy in Postmenopausal Women Having Metabolic Syndrome

Influence of Obesity on Endogenous Oxalate Synthesis