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ClinicalTrials.gov public records Last synced Sep 4, 2026, 5:33 PM EDT

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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: blood-based CRC screening Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing the Effect of a Blood-based Colorectal Cancer Screening Test on Screening Adherence and Colonoscopy Completion

NCT03598166
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Septin9
Diagnostic Test
Lead sponsor
Peter S. Liang, MD MPH
Federal
Eligibility
50 Years to 75 Years
Enrollment
359 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 4, 2023 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Colonoscopy Outreach for Rural Communities Aim 2

NCT05453630
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Patient Navigation, Usual Care Control
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
45 Years to 915 Months
Enrollment
527 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer

NCT07224750
View directory record Official record
Conditions
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC), Esophageal Squamous Cell Carcinoma (ESCC), Gastric Cancer (GC), Colorectal Cancer Screening
Interventions
Not listed
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Completed No phase listed Observational

Screening Tests in Detecting Colorectal Cancer

NCT00025025
View directory record Official record
Conditions
Colorectal Cancer
Interventions
sample testing
Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
65 Years to 80 Years
Enrollment
4,482 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
65
States / cities
Tuscon, Arizona • Oakland, California • Aurora, Colorado + 38 more
Source: ClinicalTrials.gov public record
Updated Jul 3, 2016 · Synced Sep 4, 2026, 5:33 PM EDT
Completed No phase listed Observational

Understanding Patient Preference on Colorectal Cancer Screening Options-PSU

NCT06444542
View directory record Official record
Conditions
Colo-rectal Cancer
Interventions
Guardant Shield
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
45 Years to 75 Years
Enrollment
297 participants
Timeline
2024 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

mPATH-Cloud for Colorectal Cancer Screening

NCT06441487
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Mobile Health Decision Support, Usual care
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
45 Years to 73 Years
Enrollment
1,062 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Understanding Patient Preference on Colorectal Cancer Screening Options

NCT05536713
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Guardant SHIELD blood-based colorectal cancer screening test
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
45 Years to 75 Years
Enrollment
297 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Completed No phase listed Observational

A Screening Study Targeting Tumor-specific Antigens

NCT05158621
View directory record Official record
Conditions
Metastatic Colorectal Cancer, Stage II/III Colon Cancer
Interventions
blood collection for research (next generation sequencing [NGS]), blood collection for research (HLA typing), blood collection for research (circulating tumor DNA [ctDNA])
Procedure
Lead sponsor
Gritstone bio, Inc.
Industry
Eligibility
12 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
6
States / cities
Miami, Florida • Tamarac, Florida • East Brunswick, New Jersey + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Sep 4, 2026, 5:33 PM EDT
Terminated No phase listed Observational

Colorectal Lesion Evaluation and Appropriate Resolution (CLEAR) Study

NCT07479381
View directory record Official record
Conditions
Colorectal Cancer (Diagnosis)
Interventions
Not listed
Lead sponsor
Harbinger Health
Industry
Eligibility
45 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test

NCT03688906
View directory record Official record
Conditions
Colo-rectal Cancer, Cancer Colon, Cancer, Rectum, Neoplasms,Colorectal, Polyps, Polyp of Colon, Adenoma, Adenoma Colon
Interventions
Not listed
Lead sponsor
Freenome Holdings Inc.
Industry
Eligibility
18 Years and older
Enrollment
3,275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
29
States / cities
Huntsville, Alabama • Chandler, Arizona • Tucson, Arizona + 25 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Sep 4, 2026, 5:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Plasma-based Colorectal Cancer Screening Research & Development

NCT04027790
View directory record Official record
Conditions
Colo-rectal Cancer
Interventions
Epi proColon
Diagnostic Test
Lead sponsor
Epigenomics, Inc
Industry
Eligibility
45 Years to 84 Years
Enrollment
354 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
5
States / cities
Tampa, Florida • Springfield, Illinois • New Orleans, Louisiana + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Colonoscopy or Fecal Occult Blood Test in Screening Healthy Participants for Colorectal Cancer

NCT00102011
View directory record Official record
Conditions
Colorectal Cancer
Interventions
annual screening, fecal occult blood test, screening colonoscopy, standard follow-up care
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
40 Years to 69 Years
Enrollment
4,952 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2026
U.S. locations
4
States / cities
Shreveport, Louisiana • Minneapolis, Minnesota • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings, SMARTER CRC

NCT04890054
View directory record Official record
Conditions
Colorectal Carcinoma
Interventions
Fecal Immunochemical Test, Interview, Patient Navigation
Other · Behavioral
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
5,696 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 4, 2026, 5:33 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Personal Electronic Health Records in Improving Screening Rates for Colorectal Cancer

NCT01032746
View directory record Official record
Conditions
Colorectal Cancer
Interventions
educational intervention, internet-based intervention, evaluation of cancer risk factors, fecal occult blood test, screening colonoscopy
Other · Procedure
Lead sponsor
Harvard University
Other
Eligibility
50 Years to 75 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 17, 2013 · Synced Sep 4, 2026, 5:33 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Smartphone-enabled Hybrid Identification of Early CoLorectal Disease Using Blood-Based Cancer Testing Across TeXas

NCT07398456
View directory record Official record
Conditions
Colorectal Cancer (CRC) Screening
Interventions
Educational Information via Smartphone App
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
45 Years to 84 Years
Enrollment
5,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing Interventions to Motivate and Educate

NCT01568151
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Clinic-directed intervention program, Individual Patient-Directed Program
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
50 Years to 85 Years
Enrollment
551 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Sep 4, 2026, 5:33 PM EDT
Active, not recruiting No phase listed Observational

CRC Detection Reliable Assessment With Blood

NCT05551052
View directory record Official record
Conditions
Colorectal Cancer, Adenomas Colon, Colon Cancer, Rectal Cancer, Colon Neoplasm, Colon Lesion, Colon Disease, Colon Polyp, Polyps, Adenoma, Rectal Diseases, Rectal Polyp, Gastrointestinal Neoplasms, Intestinal Neoplasms, Colonic Diseases, Functional, Intestinal Disease
Interventions
Next-Gen CRC Screening Test
Diagnostic Test
Lead sponsor
New Day Diagnostics
Network
Eligibility
45 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Chula Vista, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Multilevel Intervention Based on Colorectal Cancer (CRC) and Cervical Cancer Self-screening in Rural, Segregated Areas

NCT04471194
View directory record Official record
Conditions
Colorectal Cancer Screening, Cervical Cancer Screening
Interventions
Self-sampling HPV test, Fecal occult blood test
Diagnostic Test
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2022 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Prevention Pathways Toward Tribal Colorectal Health

NCT02882620
View directory record Official record
Conditions
Colorectal Neoplasm
Interventions
High Intensity (Group 1), Medium Intensity (Group 2), Reference Group (Group 3)
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
45 Years to 75 Years
Enrollment
1,788 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2024
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Blood-Based Colorectal Cancer (CRC) Screening Implementation Into Clinical Practice Highlands

NCT06119425
View directory record Official record
Conditions
Cancer Colon
Interventions
blood-based CRC screening
Diagnostic Test
Lead sponsor
Ballad Health
Other
Eligibility
45 Years to 84 Years
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Johnson City, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

ARGONAUT: Stool and Blood Sample Bank for Cancer Patients

NCT04638751
View directory record Official record
Conditions
Non-small Cell Lung Cancer, Colorectal Cancer, Triple Negative Breast Cancer, Pancreas Cancer
Interventions
Immunotherapy, Chemotherapy, CRC surgical resection, Colonoscopy
Drug · Procedure
Lead sponsor
Persephone Biosciences
Industry
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
10
States / cities
Orange, California • San Diego, California • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Sep 4, 2026, 5:33 PM EDT
Completed Not applicable Interventional

Increasing Colorectal Cancer Screening Among Filipino Americans

NCT00742729
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Arm 1, Arm 2, Arm 3
Behavioral
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
50 Years to 70 Years
Enrollment
906 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2016 · Synced Sep 4, 2026, 5:33 PM EDT
Recruiting No phase listed Observational

Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

NCT00843375
View directory record Official record
Conditions
Colonic Neoplasms
Interventions
Not listed
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
11
States / cities
Los Angeles, California • Urbana, Illinois • Boston, Massachusetts + 8 more
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 4, 2026, 5:33 PM EDT
Active, not recruiting Not applicable Interventional

Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health

NCT06055972
View directory record Official record
Conditions
Coronary Artery Disease, Cardiovascular Diseases, Smoking
Interventions
Educational Letter Post CT Examination
Other
Lead sponsor
American College of Radiology
Other
Eligibility
50 Years to 80 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Ann Arbor, Michigan • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 4, 2026, 5:33 PM EDT