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ClinicalTrials.gov public records Last synced Nov 5, 2026, 3:45 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 277 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: carbohydrate restricted diet Clear all

Conditions: PreDiabetes
Interventions: Low-Carbohydrate Diabetes Prevention Program; Behavioral
Lead sponsor: VA Ann Arbor Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Obesity
Interventions: Egg-based diet (EBD), Carbohydrate-based diet (CBD); Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 60 Years to 75 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Epilepsy, Seizures
Interventions: Modified Atkins Diet; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 89 Years
Enrollment: 2 participants
Timeline: 2020
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Non-alcoholic Fatty Liver Disease, Childhood Obesity, Insulin Resistance
Interventions: Carbohydrate-restricted diet, Control, low-fat diet; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 9 Years to 17 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Weight Loss, Starvation
Interventions: Caloric Restriction, Post-Exercise Protein, Energy Balance, Post-Exercise Carbohydrate, Calcium and Vitamin D; Other · Dietary Supplement
Lead sponsor: University of Nebraska Lincoln; Other
Eligibility: 19 Years to 30 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Glioblastoma
Interventions: Energy restricted Ketogenic Diet (ERKD) (Metabolic Nutritional Therapy); Other
Lead sponsor: Michigan State University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2027
U.S. locations: 1
States / cities: East Lansing, Michigan

Conditions: Diet, High-Fat, Circadian Rhythm
Interventions: High-Fat Diet, Low-Fat Diet; Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: BodyBio Balance Oil, Kirunal Fish Oil, BodyBio PC, Modified Paleolithic Elimination diet, Time Restricted Olive Oil Based (TROO) Ketogenic Diet, Usual diet with Dietary Guidelines for Americans Diet information; Dietary Supplement · Behavioral
Lead sponsor: Terry L. Wahls; Other
Eligibility: 18 Years to 70 Years
Enrollment: 162 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Tumor Surgery
Interventions: Caloric Restriction Diet; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Knee Osteoarthritis
Interventions: Low-carbohydrate diet; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 65 Years to 75 Years · Female only
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Obesity, Hypertension
Interventions: Atkins diet (low carbohydrate diet), DASH diet (high carbohydrate diet); Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 21 Years and older
Enrollment: 260 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Obesity, Weight Loss
Interventions: Low-Carbohydrate Diet, Low-fat Diet; Behavioral
Lead sponsor: Rutgers University; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 107 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Microbiota, Cancer
Interventions: DASH Diet, standard American diet; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 19 Years to 65 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Diabetes Mellitus, Obesity
Interventions: Low carbohydrate ketogenic diet, Orlistat, Low-fat diet; Behavioral · Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 69 Years
Enrollment: 146 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Sarcoidosis
Interventions: Fluorodeoxyglucose, Rubidium, FDG-PET/CT with Rb82 Myocardial Perfusion Imaging; Drug · Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cardiovascular Diseases, Inflammation
Interventions: Canola Oil, Palm Oil, Butter; Other
Lead sponsor: Ohio State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Diabetes, PreDiabetes, Metabolic Disease, Hyperglycemia, Diet Modification, Glucose Intolerance, Glucose Metabolism Disorders (Including Diabetes Mellitus), Endocrine System Diseases
Interventions: Low-Carbohydrate Diet; Behavioral
Lead sponsor: Tulane University School of Public Health and Tropical Medicine; Other
Eligibility: 40 Years to 70 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Obesity, Insulin Resistance
Interventions: Low-Carbohydrate Diet, Low-Fat Diet; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 61 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Stanford, California

Conditions: Obesity
Interventions: diet and lifestyle program; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 25 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Obesity, Insulin Resistance
Interventions: Mediterranean diet, Low-carbohydrate, ketogenic diet, Low-fat diet, Annual follow-up testing for 5 years; Behavioral · Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2029
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Food Assistance
Interventions: F&V Bonus, Restriction, Bonus & Restriction; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 296 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Obesity, Diabetes, Cardiovascular Disease
Interventions: Feeding study; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 234 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Framingham, Massachusetts

Conditions: Obesity
Interventions: High Protein, Low Protein; Behavioral
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 13 Years to 19 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Obesity
Interventions: DASH diet, standard American diet; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027
U.S. locations: 1
States / cities: Tampa, Florida

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Low-Carbohydrate Diabetes Prevention Program Among Veterans With Prediabetes

Egg Diet to Improve Metabolic Health and Function

The Effect of Ketogenic Dietary Therapy on Sleep in Adult Epilepsy

A Carbohydrate-restricted Diet to Reverse Fatty Liver in Adolescents With Obesity

Resistance Exercise and Protein During Weight Loss

Pilot Study of a Metabolic Nutritional Therapy for the Management of Primary Brain Tumors

Food and Circadian Timing

Efficacy of Diet on Quality of Life in Multiple Sclerosis

Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis

Effectiveness of a Low Carbohydrate Diet Versus a High Carbohydrate Diet in Promoting Weight Loss and Improved Health

Bitter Taste and Weight Loss in Women

DASH INtervention to INvestigate the Gut

A Low-Carbohydrate, Ketogenic Diet Versus Orlistat for Weight Loss

Optimizing Acquisition Parameters and Interpretive Methods of FDG-PET/CT With Rb-82

The Effects of Consuming Palm Oil With Different Macronutrient Intakes on Blood Lipids

Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial

Weight Loss Diet Study: Low Carb vs Low Fat

The University of Michigan OWL (Online Wellness and Lifestyle) Study

Precision Nutrition and Metabolic Function

Grocery Assistance Program Study

Framingham State Food Study

The Beneficial Effects of Healthy Snacks on Appetite Control, Satiety, and Reward-driven Eating Behavior in Young People

Modifying Diet to Improve Gut Microbiome