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Showing 1–24 of 43 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: cervical spinal manipulation Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Cervical Spine Manipulation on Gait

NCT02287324
View directory record Official record
Conditions
Cervicalgia
Interventions
Manipulation, Manual Contact
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 9, 2014 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Spinal Manipulation and Dry Needling Versus Conventional Physical Therapy in Patients With Cervicogenic Headache

NCT02373605
View directory record Official record
Conditions
Cervicogenic Headaches
Interventions
Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Phase 1Phase 2 Interventional

Cervicogenic Headache Dose-Response

NCT01530321
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Spinal Manipulation, Light Massage
Other
Lead sponsor
University of Western States
Other
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Bloomington, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Development of a Clinical Prediction Rulefor Neck Manipulation

NCT01620905
View directory record Official record
Conditions
Mechanical Neck Pain
Interventions
Manipulation
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Integrating Chiropractic Care and Mind-Body Training for the Treatment of Nonspecific Chronic Neck Pain

NCT06523036
View directory record Official record
Conditions
Neck Pain, Nurse-Patient Relations
Interventions
Combined chiropractic care and Tai Chi
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Validation of the Cervicothoracic Differentiation Test

NCT06287242
View directory record Official record
Conditions
Neck Pain
Interventions
spinal manipulation
Other
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Sep 7, 2026, 2:23 PM EDT
Completed No phase listed Observational

Prospective Study of Post Surgical Continued Spinal Pain Patients

NCT05401682
View directory record Official record
Conditions
Low Back Pain, Cervical Pain, Neck Disorder, Low Back Disorder, Spine Injury
Interventions
Cox chiropractic care
Other
Lead sponsor
Keiser University College of Chiropractic Medicine
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 7, 2026, 2:23 PM EDT
Not listed Not applicable Interventional

The Effects of Thoracic Spine Manipulation in Individuals With Non-traumatic Cervical Pain

NCT01760590
View directory record Official record
Conditions
Neck Pain, Cervical Pain
Interventions
Manual Manipulation, Mobilization
Procedure
Lead sponsor
Keystone Rehabilitation Systems
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Bridgeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 3, 2013 · Synced Sep 7, 2026, 2:23 PM EDT
Suspended Not applicable Interventional

A Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain

NCT02972710
View directory record Official record
Conditions
Neck Pain
Interventions
Supine thoracic spine thrust manipulation, Seated thoracic spine thrust manipulation
Other
Lead sponsor
Northern Arizona University
Other
Eligibility
20 Years to 50 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Sep 7, 2026, 2:23 PM EDT
Recruiting Not applicable Interventional

Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care

NCT05726331
View directory record Official record
Conditions
Neck Pain, Chronic Pain
Interventions
Chiropractic Care, Tai Chi, Enhanced Usual Care
Other
Lead sponsor
Harvard University Faculty of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of the Effect of Spine Grade I and II Manipulation and a PNE Video on Brainwaves: Pilot Study

NCT04908670
View directory record Official record
Conditions
Chronic Pain, Manipulation, Psychologic
Interventions
Understanding Pain in less than 5 minutes, and what to do about it! https://www.youtube.com/watch?v=C_3phB93rvI, PA manipulation
Behavioral · Procedure
Lead sponsor
Florida Gulf Coast University
Other
Eligibility
20 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Merrillville, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Effects of Cervical Manipulation on Cervical Rotation Motion and Shoulder Rotational Motion and Strength in Overhead Athletes

NCT06903793
View directory record Official record
Conditions
Cervical Spine, Manipulation, Spinal, Shoulder, Overhead Athlete
Interventions
cervical manipulation
Other
Lead sponsor
Sacred Heart University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Fairfield, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Sep 7, 2026, 2:23 PM EDT
Recruiting Not applicable Interventional

Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

NCT06906107
View directory record Official record
Conditions
Neck Pain Musculoskeletal, Neck Pain Treatment, Cervicalgia
Interventions
Cervical Manipulation, Exercise, Mobilization
Procedure
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 70 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Rochester, Minnesota • Syracuse, New York • Waco, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Phase 2 Interventional

Chiropractic Care, Medication, and Self-Care for Neck Pain

NCT00029770
View directory record Official record
Conditions
Neck Pain
Interventions
Chiropractic spinal manipulation, Acetaminophen, Self-care, Non-Steroidal anti-inflammatory drugs (NSAIDS), Tylenol with codeine
Procedure · Drug · Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 24, 2008 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuroendocrine Changes in Cervical Spinal Manipulation and Mobilization Non-specific Mechanical Neck Pain

NCT04911608
View directory record Official record
Conditions
Neck Pain
Interventions
cervical spinal manipulation, cervical spinal mobilization
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Effects of Cervical Spine Manipulation On Postural Control

NCT00524654
View directory record Official record
Conditions
Posture
Interventions
HVLA chiropractic manipulation
Procedure
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 16, 2008 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sacroiliac Orthopedic Blocking and Cervical Spine Function

NCT00523822
View directory record Official record
Conditions
Musculoskeletal Diseases
Interventions
Spinal Manipulative Therapy
Other
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 4, 2008 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Phase 2 Interventional

Chiropractic and Exercise for Seniors With Neck Pain

NCT00269308
View directory record Official record
Conditions
Neck Pain
Interventions
Chiropractic Manual treatment + home exercise ( procedure+behavior), Supervised rehabilitative exercise + home exercise, Home exercise
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
65 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 22, 2011 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Cervical and Upper Thoracic Mobilization and Manipulation for Mechanical Neck Pain

NCT02036905
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical and thoracic mobilization, cervical and thoracic manipulation
Other
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Solon, Ohio • Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Lumbopelvic Manipulation on Neuromuscular Activity of Back & Hip Muscles in Adults With Chronic Low Back Pain

NCT01861418
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lumbopelvic Manipulation, Sham manipulation
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
20 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2017 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Manual Therapy on Shoulder Function

NCT04513535
View directory record Official record
Conditions
Musculoskeletal Manipulations, Shoulder, Range of Motion, Muscle Strength, Surface Electromyography
Interventions
Thoracic Manipulation, Cervical Manipulation, glenohumeral posterior glide mobilization, Sleeper stretch
Other
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Dry Needling and Manipulation vs. Mobilization, Exercise and Interferential Electrotherapy for Shoulder Impingement (Subacromial Pain Syndrome)

NCT03168477
View directory record Official record
Conditions
Subacromial Pain Syndrome
Interventions
dry needling, spinal manipulation, mobilization, exercise, modalities
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cockeysville, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional Results available

Chiropractic for Hypertension in Patients

NCT01020435
View directory record Official record
Conditions
Hypertension
Interventions
Spinal Manipulation, Sham Spinal Manipulation
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 75 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Sep 7, 2026, 2:23 PM EDT
Completed Not applicable Interventional

Short-Term Response of Thoracic Spine Manipulation With or Without Trigger Point Dry Needling for Mechanical Neck Pain

NCT02415660
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spinal manipulation, Trigger point dry needling, Cervical range of motion exercises, Posterior neck muscle activation exercise, Trigger point dry needling sham, Seirin J-type stainless steel needles, 0-2-0.3 x 40-50 mm
Procedure · Behavioral · Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Sep 7, 2026, 2:23 PM EDT