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ClinicalTrials.gov public records Last synced Oct 30, 2026, 1:38 PM EDT

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Showing 25–48 of 308 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: chlorhexidine Clear all
Completed No phase listed Observational

Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate

NCT04777695
View directory record Official record
Conditions
Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
Interventions
Decibel Monitor
Other
Lead sponsor
Children's National Research Institute
Other
Eligibility
Up to 22 Years
Enrollment
64 participants
Timeline
2021
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 1, 2021 · Synced Oct 30, 2026, 1:38 PM EDT
Recruiting Not applicable Interventional

Irrisept Solution for Instrumented Spine Surgery

NCT06439953
View directory record Official record
Conditions
Post-Op Complication, Spine Surgery, Site Infection, Surgical Site Infection, Spinal Instrumentation, Index Spinal Instrumentation, Layer-by-Layer Closure, Locoregional Flap-Based Closure
Interventions
Chlorhexidine gluconate solution, Vancomycin
Device · Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics

NCT00692484
View directory record Official record
Conditions
Healthy
Interventions
Chlorhexidine gluconate, Povidone iodine
Drug
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years to 90 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 30, 2026, 1:38 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Caries Transmission Prevention in Alaska Native Infants

NCT00067340
View directory record Official record
Conditions
Dental Caries
Interventions
Chlorhexidine mouth rinse, Xylitol chewing gum
Drug · Other
Lead sponsor
University of Washington
Other
Eligibility
Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 2, 2015 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Components of Chlorhexidine Gluconate Dressing

NCT01112020
View directory record Official record
Conditions
Healthy
Interventions
CHG Catheter Dressing Patch, Biopatch, Tegaderm CHG
Device
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Eliminate Risk of Cardiac Surgical Site Events

NCT01425697
View directory record Official record
Conditions
Surgical Site Infections
Interventions
2% Chlorhexidine Gluconate cloths, Standard of Care preoperative preparation.
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
739 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
4
States / cities
Lexington, Kentucky • Ridgewood, New Jersey • Rochester, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2013 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In-vivo Efficacy Study of Patient Pre-operative Preps

NCT01968707
View directory record Official record
Conditions
Bacterial Reduction on Skin Flora Post-product Application
Interventions
ChloraPrep Hi-Lite Orange, Normal saline, 3M CHG/IPA Prep Tint 10.5-mL, 3M CHG/IPA Prep Tint 26-mL
Drug
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
426 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Oct 30, 2026, 1:38 PM EDT
Recruiting Not applicable Interventional

Peri-implantitis Management: Surgical and Maintenance Outcomes

NCT07550127
View directory record Official record
Conditions
Peri-implantitis
Interventions
Resective surgery with implantoplasty, Resective surgery with mechanical debridement
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 30, 2026, 1:38 PM EDT
Completed No phase listed Observational

Prehospital Ventilator-Associated Pneumonia Prevention Trial

NCT01902446
View directory record Official record
Conditions
Wounds and Injuries, Respiratory Failure, Pneumonia, Ventilator-Associated
Interventions
Chlorhexidine gluconate
Drug
Lead sponsor
Nicholas M Mohr
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 2 Interventional Results available

STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)

NCT03489629
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Trimethoprim Sulfamethoxazole (TMP/SMX), Minocycline, Mupirocin, Chlorhexidine Gluconate, Environmental Decontamination
Drug · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
2 Years to 45 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
9
States / cities
Denver, Colorado • Indianapolis, Indiana • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 30, 2026, 1:38 PM EDT
Withdrawn Phase 2 Interventional

Gargling and Nasal Rinses to Reduce Oro- and Nasopharyngeal Viral Load in Patients With COVID-19

NCT04344236
View directory record Official record
Conditions
COVID-19
Interventions
Saline oral/nasal rinse, 0.5% Povidone/Iodine oral/nasal rinse, 0.12% Chlorhexidine oral/nasal rinse
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 79 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 4 Interventional

A Peri-intubation Oral Intervention to Reduce Oral Flora and VAP

NCT00248300
View directory record Official record
Conditions
Pneumonia
Interventions
Chlorhexidine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 30, 2026, 1:38 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Pilot Study to Evaluate the Effect of Multiple Passes on Port Wine Stain Treatments With the Cutera Excel V™ Laser.

NCT04103164
View directory record Official record
Conditions
Port-Wine Stain
Interventions
Cutera excel V™ Laser
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 15, 2019 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Surgical Preparation Solutions in Knee Surgery

NCT01857349
View directory record Official record
Conditions
Arthroplasty, Replacement
Interventions
Chlora Prep, Dura Prep
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 89 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2020 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Skin Glue Versus Suture for Securing Radial Arterial Lines

NCT06589284
View directory record Official record
Conditions
Arterial Catheters, Catheter Related Complication
Interventions
Silk 0-0 suture covered by chlorhexidine gluconate dressing, 2-octyl cyanoacrylate covered by chlorhexidine gluconate dressing
Procedure
Lead sponsor
CHRISTUS Health
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 4 Interventional Results available

BPO vs Hibiclens Soap for Surgical Preparation

NCT04021524
View directory record Official record
Conditions
Propionibacterium Acnes
Interventions
Benzoyl Peroxide 10% Bar, Chlorhexidine Gluconate
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 89 Years · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Antimicrobial Activity of IV Clear™ Dressing - Prevention of Antimicrobial Regrowth

NCT01368120
View directory record Official record
Conditions
Skin Flora Infection
Interventions
IV Clear™ Dressing, Tegaderm CHG™, Silicone Vehicle Control Dressing
Device
Lead sponsor
Covalon Technologies Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Miamiville, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Single-Center 2-Arm Study for Lentigines on the Hands

NCT02763072
View directory record Official record
Conditions
Lentigines
Interventions
Enlighten Laser, Excel V Laser
Device
Lead sponsor
Cutera Inc.
Industry
Eligibility
30 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Naperville, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 2, 2023 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Excel V 532 nm KTP Laser for Treatment of Erythematotelangiectatic Rosacea & Papulopustular Rosacea

NCT02268474
View directory record Official record
Conditions
Erythematotelangiectatic Rosacea, Papulopustular Rosacea
Interventions
532nm KTP Laser vs 595nm Pulse Dye Laser
Device
Lead sponsor
Cutera Inc.
Industry
Eligibility
20 Years to 80 Years · Female only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Blue Light Therapy of C. Acnes

NCT04300010
View directory record Official record
Conditions
Acne
Interventions
5% Topical Benzoyl Peroxide Gel, Blue Light Therapy
Drug · Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 30, 2026, 1:38 PM EDT
Completed No phase listed Observational

Detection, Education, Research and Decolonization Without Isolation in Long-term Care Facilities

NCT01302210
View directory record Official record
Conditions
Methicillin Resistant Staphylococcus Aureus
Interventions
Decolonization
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
22,302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Oct 30, 2026, 1:38 PM EDT
Recruiting Not applicable Interventional

Effect of Chlorhexidine Gluconate Bladder Instillations in Patients With Chronic Suprapubic Catheters on Unplanned Healthcare Encounters and Quality of Life

NCT06163469
View directory record Official record
Conditions
Neurogenic Bladder, Urinary Retention
Interventions
Bladder instillation with Irrisept
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 2 Interventional

Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures

NCT05090657
View directory record Official record
Conditions
Surgical Site Infections, Nosocomial Infection, Healthcare Associated Infections
Interventions
methylene blue 0.01%/chlorhexidine gluconate 0.25% + light activation
Combination Product
Lead sponsor
Ondine Biomedical Inc.
Industry
Eligibility
18 Years and older
Enrollment
322 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Savannah, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 22, 2022 · Synced Oct 30, 2026, 1:38 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluating Safety and Effectiveness of Octenidine Dihydrochloride

NCT03140254
View directory record Official record
Conditions
Preoperative Skin Preparation
Interventions
Chlorhexidine gluconate, N,N'-(1,10-decanediyldi-1(4H)-Pyridinyl-4-ylidene)-Bis-(1-octanamine) Dihydrochloride, Placebo
Drug
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Butte, Montana
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 30, 2026, 1:38 PM EDT