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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: cigarette group Clear all
Recruiting Phase 2 Interventional Accepts healthy volunteers

Kick-Nic! Youth Quit Vaping App

NCT06662305
View directory record Official record
Conditions
Nicotine Vaping
Interventions
Kick-Nic! mobile phone application, NCI Quit Vaping website
Behavioral
Lead sponsor
Yale University
Other
Eligibility
12 Years to 19 Years
Enrollment
306 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 23, 2026, 9:04 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Understanding Vape Marketing Study

NCT07129265
View directory record Official record
Conditions
E-cigarette, Vaping, Tobacco, Nicotine, Adolescent Behavior, Video Information, Digital Education Interventions
Interventions
Working group, Focus group
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
13 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Utilizing Augmented Reality as an Adjunct for Smoking Cessation

NCT04101422
View directory record Official record
Conditions
Smoking
Interventions
Augmented Reality 1, Augmented Reality 2, Augmented Reality 3, Augmented Reality 4
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes

NCT05706701
View directory record Official record
Conditions
Nicotine Vaping
Interventions
Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine), Nicotine vaping visit 2 (protonated nicotine)
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Phase 2 Interventional Results available

Randomized Trial to Evaluate the Effectiveness of X-22 as a Smoking Cessation Aid

NCT01400815
View directory record Official record
Conditions
Smoking Cessation
Interventions
X-22 Smoking Cessation Product, Active Control Cigarettes
Drug
Lead sponsor
22nd Century Limited, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
3
States / cities
Sacramento, California • Metairie, Louisiana • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2021 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing Cigarette Use Among Urban Youth Via an M-Health Primary Care Preventive Intervention

NCT03855410
View directory record Official record
Conditions
Tobacco Use, Drug Use, Adolescent Behavior, Alcohol Use, Sexual Risk Behavior
Interventions
S4E, Attention-Matched Control Group
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
13 Years to 21 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Ann Arbor, Michigan • Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Sep 23, 2026, 9:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Smoking Cessation Via Telehealth Options in Primary Care

NCT05493254
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smoking cessation e-visit, Treatment As Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Sep 23, 2026, 9:04 PM EDT
Recruiting Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

NCT07202039
View directory record Official record
Conditions
Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Interventions
Brief individual counseling sessions
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 23, 2026, 9:04 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Addressing Tobacco, E-Cigarette, and Cannabis Waste

NCT05751369
View directory record Official record
Conditions
Knowledge, Attitudes, Practice
Interventions
Education plus Support
Behavioral
Lead sponsor
California State University, San Marcos
Other
Eligibility
18 Years to 25 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Davis, California • San Marcos, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 23, 2026, 9:04 PM EDT
Terminated Not applicable Interventional

Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.

NCT05569005
View directory record Official record
Conditions
COPD, Smoking, Tobacco Use
Interventions
THS use, Cigarette, Smoking Abstinence
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
35 Years to 65 Years
Enrollment
715 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
81
States / cities
Brandon, Florida • Cape Coral, Florida • Clearwater, Florida + 41 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Sep 23, 2026, 9:04 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention

NCT06483412
View directory record Official record
Conditions
Tobacco Use Cessation, Addiction
Interventions
Healthy Futures: Alternative-to-Suspension Curriculum
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 18 Years
Enrollment
2,540 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Results available

Smoking Cessation Pilot for People Living With HIV (PLWH)

NCT04808609
View directory record Official record
Conditions
Smoking Cessation, Smoking, Smoking Behaviors, Smoking Reduction, Smoking, Tobacco, Smoking, Cigarette, Hiv, HIV/AIDS
Interventions
Lumme mobile phone application, Standard of Care
Device · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of the Pivot Breath Sensor: Single-Arm Cohort Study

NCT04133064
View directory record Official record
Conditions
Smoking Reduction, Smoking Behaviors, Smoking, Tobacco, Smoking Cessation
Interventions
Pivot Breath Sensor
Device
Lead sponsor
Jennifer Marler, MD
Industry
Eligibility
18 Years to 80 Years
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Sep 23, 2026, 9:04 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Neurobiology of Alcohol and Nicotine Co-Addiction

NCT03338933
View directory record Official record
Conditions
Alcohol Use Disorder, Nicotine Use Disorder
Interventions
magnetic resonance imaging (MRI)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 23, 2026, 9:04 PM EDT
Not listed No phase listed Observational

Effectiveness of Smoking Cessation Program in a Community Health System

NCT05107687
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smoking cessation
Behavioral
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Sep 23, 2026, 9:04 PM EDT
Active, not recruiting No phase listed Observational

Accurate Point of Care Liver Disease Diagnostics

NCT05986916
View directory record Official record
Conditions
NAFLD, Nonalcoholic Fatty Liver
Interventions
Liverscope® exam, MR exam, FibroScan® exam (optional), Blood draw, Body measurements, Questionnaires
Diagnostic Test · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional

Project 2: Strategies for Reducing Nicotine Content in Cigarettes

NCT02139930
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Smoking
Interventions
Normal Nicotine Control Group, Immediate Nicotine Reduction Group, Gradual Nicotine Reduction Group
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
1,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
10
States / cities
Phoenix, Arizona • San Francisco, California • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

NCT03691350
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration
Procedure · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 52 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Addictive Potential of LCCs in Dual Users

NCT03496077
View directory record Official record
Conditions
Tobacco Use Disorder, Dual Tobacco Use, Tobacco Dependence, Smoking, Smoking, Cigar, Smoking, Cigarette, Smoking, Tobacco
Interventions
Flavored and unflavored little cigars/cigarillos (LCCs)
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 34 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Phase 4 Interventional Results available

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia

NCT02420015
View directory record Official record
Conditions
Schizophrenia, Cigarette Smoking
Interventions
Nicotine replacement therapy, Bupropion, cognitive-behavioral smoking cessation counseling, Mobile Contingency Management, Stay Quit Coach, SMS text messaging
Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Pharmacology of Electronic Cigarettes

NCT02470754
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Tobacco Cigarette, Electronic Cigarette
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 23, 2026, 9:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vape-Free Text-Messaging: Pilot Study

NCT05906082
View directory record Official record
Conditions
E-cigarette Use
Interventions
E-cigarette cessation text-messaging intervention, Standard care control using standard national resources
Behavioral
Lead sponsor
Jovan Gwon, PhD, RN, FIAAN
Other
Eligibility
18 Years to 24 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Sep 23, 2026, 9:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimal TTM Tailoring for Population Cessation

NCT01544010
View directory record Official record
Conditions
Smoking Cessation
Interventions
Stage-Tailored Manual, Stage Tailored Feedback Report, Moderate TTM-Tailored Feedback Report, Full TTM-Tailored Feedback Report, Enhanced TTM+Addiction Tailored Feedback Report
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
3,006 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Sep 23, 2026, 9:04 PM EDT
Recruiting Phase 4 Interventional

Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

NCT07089901
View directory record Official record
Conditions
Smoking
Interventions
transdermal nicotine replacement therapy
Drug
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 23, 2026, 9:04 PM EDT