Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:06 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 134 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: cigarette or e-cigarette Clear all

Conditions: Smoking Cessation, Electronic Cigarette Use
Interventions: Varenicline, Nicotine patch, Dual Focused Cessation Counseling, Smoking Focused Cessation Counseling, Counseling Intensity: 1 Session, Counseling Intensity: 4 Sessions; Drug · Behavioral · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: E-Cig Use
Interventions: E-cig use; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 29 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Study Focuses on Brain Morphology and Cognition in Older Subjects
Interventions: Not listed
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 60 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Use Disorder
Interventions: Flavoring Agents, Nicotine; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Smoking
Interventions: Cigarettes, E-Cigarette, Nicotine Gum or Lozenge; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 264 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio

Conditions: Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions: Electronic Cigarette, Oral Nicotine Pouch; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years to 55 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Electronic Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: San Francisco, California

Conditions: THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions: Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Perceptions of Tobacco Products
Interventions: Each intervention will be a picture of a social media post. The posts will vary (in a 3X2 factorial design) the type of flavor described and whether concealability is described.; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years to 17 Years
Enrollment: 4,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Electronic Cigarette Related Lung Damage
Interventions: Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test, Chest CT; Drug · Diagnostic Test
Lead sponsor: Y. Michael Shim, MD; Other
Eligibility: 18 Years to 35 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2032
U.S. locations: 2
States / cities: Durham, North Carolina • Charlottesville, Virginia

Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions: Acute (24-hour) abstinence, Ad libitum smoking/vaping; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 21 Years to 50 Years
Enrollment: 370 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Vaping, Underage
Interventions: IKE System; Other
Lead sponsor: IKE Tech; Industry
Eligibility: 18 Years and older
Enrollment: 102 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 4
States / cities: Los Angeles, California • Chicago, Illinois • New York, New York + 1 more

Conditions: Tobacco Use Disorder, Smoking
Interventions: e-cigarettes; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years to 35 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Electronic Cigarettes
Interventions: Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet, ECIG 0 mg nicotine, sweetened, ECIG 0 mg nicotine, unsweet; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Nicotine Addiction
Interventions: Nicotine patch and gum, Minnesota Nicotine Withdrawal Scale (MNWS), ASSIST (the Alcohol, Smoking and Substance Involvement Screening), Counseling, NIDA Standardized Research E-cigarettes (SREC); Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Vascular Health
Interventions: Electronic cigarette, traditional cigarette, (sham cigarette) - no actual exposure to cigarettes; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 50 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking, Tobacco Use
Interventions: Product A, Product B, Product C, Product D, Product E, Product F, Product G, Product N; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 2
States / cities: Lexington, Kentucky • Knoxville, Tennessee

Conditions: Cigarette Smoking
Interventions: E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging; Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema, Asthma-COPD Overlap Syndrome
Interventions: E-Cigarette, Financial Incentives; Other · Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 40 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid, Tobacco Smoking
Interventions: JUUL, Tobacco; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Tobacco Dependence
Interventions: Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge); Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 232 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Healthy Volunteers
Interventions: Use electronic cigarette or smoke conventional cigarette; Other
Lead sponsor: British American Tobacco (Investments) Limited; Industry
Eligibility: 21 Years to 55 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015
U.S. locations: 1
States / cities: Burbank, California

Conditions: Smoking
Interventions: Ecig group 1; Other
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years and older
Enrollment: 117 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Search by objective public record fields.

The Avenues Study: Dual Use Cessation

The Impact of Chronic E-Cigarette Usage on Microvascular Health

Cannabis Effects on Brain Morphology in Aging

Effects of E-cigarette Flavors on Youth TCORS 2.0

Methods Project 4: Clinical Trial - Amended

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

THC Crossover Study

Social Media Influences on Engagement and Susceptibility to Non-combustible Tobacco Product Use Among Youth and Young Adults (AYA)

Vaping High vs. Low Nicotine E-Liquid

Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

Vaping and Smoking Withdrawal Project

Human Factors Validation and Usability Testing of the IKE Age-Gating System

Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy

The Effect of Electronic Cigarette Liquid Characteristics in Smokers.

Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS

Investigation of the Effects of Electronic Cigarettes on Vascular Health

Modern Nicotine Oral Product Abuse Liability

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

UW Withdraw From Tobacco Study

Pharmacokinetic Study Comparing Nicotine Delivery From E-cigarettes and a Conventional Cigarette in Healthy Subjects

The Moment Study: Mixed Method E-cigarette Study