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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:31 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 134 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: cigarette or e-cigarette Clear all

Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions: Acute (24-hour) abstinence, Ad libitum smoking/vaping; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 21 Years to 50 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Cigarette Smoking, Smoking, Tobacco
Interventions: Break the Chain, Clearing the Air; Behavioral
Lead sponsor: Oregon Center for Applied Science, Inc.; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 307 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Cigarette Smoking, Smoking Behaviors
Interventions: Switching to E-Cigarette, Switching using Medication; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 225 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking, Smoking Behaviors, Treatment
Interventions: Switching to a different medication, Continued use of the same medication, Switching to a harm reduction tobacco product; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 544 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
Interventions: HRP Sampling period, NPL Sampling period; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years and older
Enrollment: 472 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use
Interventions: Regulated ad condition, Unregulated ad condition; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 26 Years
Enrollment: 195 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Smoking Cessation
Interventions: Enhanced E-cigarette Coaching, Quitline treatment as usual; Behavioral
Lead sponsor: Consumer Wellness Solutions; Industry
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Behavior, Health Risk, Implementation Science, E Cigarette Use, Cessation, Smoking, Incentives, Engagement, Patient, Peer Support, Media Literacy
Interventions: Text-massaging suport, Financial incentive, Media literacy; Behavioral
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 29 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Cigarette Smoker, Current Smoker, Healthy Subject
Interventions: Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study, Questionnaire Administration; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years to 55 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Tobacco-Related Carcinoma
Interventions: Behavioral Intervention, Survey Administration; Behavioral · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years to 30 Years
Enrollment: 607 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoker, Current Every Day Smoker
Interventions: Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration; Procedure · Drug · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 52 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Smoking Cessation, Harm Reduction
Interventions: Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, BIDI e-cigarette, on!; Drug · Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Tobacco Use Disorder
Interventions: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: E Cig Use
Interventions: Not listed
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years to 25 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Vaping, Nicotine, Vaping
Interventions: CA35, CM35, Cig; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 24 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: High Point, North Carolina

Conditions: Vaping, Cessation, Tobacco
Interventions: This is Quitting, Assessment only control, Waitlist control; Behavioral · Other
Lead sponsor: Truth Initiative; Other
Eligibility: 13 Years to 17 Years
Enrollment: 1,681 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Tobacco Dependence
Interventions: SWITCH IT, E-cig Provision Only; Behavioral · Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Louisville, Kentucky • Providence, Rhode Island

Conditions: E-cigarette Use
Interventions: Live Free From E-cigarettes; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years to 24 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
Interventions: E-cigarette; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 2
States / cities: Louisville, Kentucky • Lawrence, Massachusetts

Conditions: Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions: Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Arterial Inflammation
Interventions: No drug or device, only a test. The test is called a PET/CT; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking Behaviors
Interventions: Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions.; Drug
Lead sponsor: JT International SA; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 2
States / cities: Knoxville, Tennessee • San Antonio, Texas

Conditions: Tobacco Use, Substance Use Disorders
Interventions: Switching to E-Cigarette, Quitting using Medication, Counseling; Behavioral · Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Charleston, South Carolina • Conway, South Carolina • Greenville, South Carolina + 1 more

Conditions: Smoking
Interventions: Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 153 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Search by objective public record fields.

Vaping and Smoking Project in People With Schizophrenia

Internet-Based Nonsmoking Program for Postpartum Women

Switch or Quit R01

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Responses to Regulated E-Cigarette Advertisements

Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes

Incentive-based and Media Literacy Informed Approaches to Improve Vaping Cessation

Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers

Oral Nicotine Product Messaging to Communicate Risk of Use for Young Adults

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

Young Adult EC Use and Respiratory Outcomes

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

Text Message Quit Vaping Intervention for Adolescents

Harm Reduction for Smokers With Mental Illness

An Online Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults

The Appeal and Impact of E-cigarettes in Smokers With SMI

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

Arterial Inflammation and E-Cigarettes

Nicotine Pouch Pharmacokinetics Abuse Liability

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum