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ClinicalTrials.gov public records Last synced Oct 22, 2026, 8:55 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 1,028 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: cigarettes Clear all
Recruiting Phase 2 Interventional

Cannabidiol for Reducing Cigarette Use

NCT06218056
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Smoking, Tobacco Dependence
Interventions
Cannabidiol (CBD) 800 mg, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
North Hollywood, California
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

NCT03185546
View directory record Official record
Conditions
Smoking
Interventions
NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 14, 2021 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Phase 2 Interventional Results available

Varenicline vs Placebo for the Treatment of Methamphetamine Dependence

NCT01011829
View directory record Official record
Conditions
Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 14, 2013 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Results available

Clinical Trial of Smoking Cessation Mobile Phone Program

NCT02656745
View directory record Official record
Conditions
Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder, Tobacco Dependence
Interventions
Mobile Smoking Cessation Solution
Device
Lead sponsor
Click Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Oct 22, 2026, 8:55 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Guiding Good Choices for Health

NCT04040153
View directory record Official record
Conditions
Adolescent Substance Use
Interventions
Guiding Good Choices
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 12 Years
Enrollment
3,636 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
3
States / cities
Oakland, California • Aurora, Colorado • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Oct 22, 2026, 8:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Human Factors Validation and Usability Testing of the IKE Age-Gating System

NCT06952569
View directory record Official record
Conditions
Vaping, Underage
Interventions
IKE System
Other
Lead sponsor
IKE Tech
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
4
States / cities
Los Angeles, California • Chicago, Illinois • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional

Effects of Cigar Flavors on Measures of Abuse Liability Among Young Adults

NCT02937051
View directory record Official record
Conditions
Tobacco Products
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 21 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

NCT05030194
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions
Electronic Cigarette, Oral Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 22, 2026, 8:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers

NCT01692353
View directory record Official record
Conditions
Cardiovascular Disease, Cigarette Smoking
Interventions
Subject's usual brand (UB) tobacco product
Other
Lead sponsor
R.J. Reynolds Tobacco Company
Industry
Eligibility
26 Years to 49 Years · Male only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 17, 2016 · Synced Oct 22, 2026, 8:55 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Communicating About Nicotine Reduction in Cigarettes

NCT06787937
View directory record Official record
Conditions
Tobacco Products, Smoking Behavior, Cigarette Use
Interventions
VLNC messages, Control message
Behavioral
Lead sponsor
Georgia State University
Other
Eligibility
21 Years and older
Enrollment
1,230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Results available

Screening, Brief Intervention, and Referral to Treatment in Primary Care

NCT01966432
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Substance-related Disorders
Interventions
Referral to Treatment, Brief Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 3, 2018 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Behavioral Memory Modulation in Nicotine Addiction

NCT03744559
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
25 Years to 65 Years
Enrollment
191 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Oct 22, 2026, 8:55 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

NCT02730676
View directory record Official record
Conditions
Smoking
Interventions
Electronic Cigarette #1, Electronic Cigarette #2
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Phase 4 Interventional Results available

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

NCT04020718
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Brief telephone advice plus tailored text messages, Mailed nicotine replacement therapy, Proactive telephone coaching
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder

NCT04063267
View directory record Official record
Conditions
Cigarette Smoking, Addiction, E Cig Use
Interventions
E cigarettes, Nicotine Replacement Therapy
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Repeated Cannabis Administration on Experimental Pain and Abuse Liability

NCT04576507
View directory record Official record
Conditions
Cannabis, Pain, Tolerance, Hyperalgesia
Interventions
Active Cannabis, Placebo Cannabis
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 8, 2025 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Vaporized Nicotine and Autonomic Control

NCT04613609
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Electronic Cigarette containing nicotine, Electronic Cigarette without nicotine
Device
Lead sponsor
Michigan Technological University
Other
Eligibility
21 Years to 40 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houghton, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

NCT04053868
View directory record Official record
Conditions
Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid, Tobacco Smoking
Interventions
JUUL, Tobacco
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Results available

Smoking Cessation Pilot for People Living With HIV (PLWH)

NCT04808609
View directory record Official record
Conditions
Smoking Cessation, Smoking, Smoking Behaviors, Smoking Reduction, Smoking, Tobacco, Smoking, Cigarette, Hiv, HIV/AIDS
Interventions
Lumme mobile phone application, Standard of Care
Device · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 22, 2026, 8:55 PM EDT
Completed No phase listed Observational

Electronic Cigarette Use During Pregnancy

NCT03480373
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
182 participants
Timeline
2018 – 2023
U.S. locations
6
States / cities
Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

NCT03625986
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD1601: A Study to Evaluate the Exposure to Tar and Nicotine From Two Cigarette Products That Contain a Menthol Capsule in the Filter

NCT04529551
View directory record Official record
Conditions
Smoking, Tobacco Smoking, Tobacco Use
Interventions
1601A, 1601B
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 22, 2026, 8:55 PM EDT
Terminated Phase 2 Interventional Results available

Celecoxib for Thyroid Eye Disease

NCT02845336
View directory record Official record
Conditions
Thyroid Eye Disease
Interventions
Celecoxib, artificial tears
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 31, 2020 · Synced Oct 22, 2026, 8:55 PM EDT
Completed Not applicable Interventional Results available

iQuit Mindfully: Text Messaging for Smoking Cessation

NCT03029819
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Mindfulness-based Addiction Treatment, iQuit Mindfully, Self-Help guide, Nicotine Patch
Behavioral · Drug
Lead sponsor
Georgia State University
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Oct 22, 2026, 8:55 PM EDT