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Showing 1–24 of 551 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: cocaine Clear all
Completed Phase 2 Interventional Accepts healthy volunteers

Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone

NCT00218608
View directory record Official record
Conditions
Cocaine-Related Disorders, Opioid-Related Disorders
Interventions
Disulfiram
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 30, 2012 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Buprenorphine Naltrexone-P1 A-Cocaine

NCT00733720
View directory record Official record
Conditions
Cocaine-related Disorders
Interventions
Suboxone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional

Tryptophan and Behavior Therapy for Cocaine Abuse - 1

NCT00000324
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Tryptophan
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 2, 2026, 5:22 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Young Adult Naturalistic Alcohol Study (YANAS) Using Smartphone Technology in a Simulated Laboratory Environment

NCT02841735
View directory record Official record
Conditions
Alcohol Use, Alcohol Drinking, Drinking Behavior
Interventions
Smartphone breathalyzer device/app use, BAC estimator app use, Text messaging procedure
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 25 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 2, 2018 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

PET Imaging in Cocaine Self Administration

NCT02181491
View directory record Official record
Conditions
Cocaine Dependence
Interventions
[11C]-P943
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional Results available

Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals

NCT01963091
View directory record Official record
Conditions
Cocaine Dependence
Interventions
oxytocin, saline
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2018 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Intranasal Cocaine and Temperature Regulation During Exercise

NCT05809453
View directory record Official record
Conditions
Hyperthermia, Cocaine Use, Exercise
Interventions
Cocaine, Lidocaine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 1 Interventional

The Effects of Minocycline in Humans

NCT02193269
View directory record Official record
Conditions
Memory Impairment
Interventions
Sugar pill, Minocycline
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Sep 2, 2026, 5:22 AM EDT
Completed No phase listed Observational

Treatment Study: Reducing Cocaine/Heroin Abuse With SR-Amphetamine and Buprenorphine (ARC)

NCT00698737
View directory record Official record
Conditions
Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
Interventions
Not listed
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 21, 2012 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 1 Interventional

Cocaine-Methylphendidate Interaction Study - 4

NCT00015067
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Methylphenidate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 45 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1997
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Behavioral Effects of Drugs: Inpatient (35)

NCT03519022
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Cocaine, Placebo oral capsule, Methylphenidate
Drug
Lead sponsor
Craig Rush
Other
Eligibility
18 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional Results available

Vigabatrin for Treatment of Cocaine Dependence

NCT00611130
View directory record Official record
Conditions
Cocaine Dependence
Interventions
vigabatrin, placebo
Drug
Lead sponsor
Catalyst Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
11
States / cities
Little Rock, Arkansas • San Francisco, California • Torrance, California + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Neurobiology of Serotonin and Addiction

NCT00732901
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Escitalopram, Placebo
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 1 Interventional

ALK33BUP-101: Safety and Pharmacodynamic Effects of ALKS 33-BUP Administered Alone and When Co-administered With Cocaine

NCT01366001
View directory record Official record
Conditions
Cocaine Abuse
Interventions
ALKS 33-BUP, ALKS 33, Placebo
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
21 Years to 50 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 1 Interventional

Modafinil - Escitalopram Study for Cocaine Dependence

NCT01601730
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
Interventions
Modafinil and Escitalopram, Placebo, Modafinil, Escitalopram
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 17, 2012 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional Results available

HBPL Study of the Impact of the NK1 Antagonist Aprepitant

NCT01176591
View directory record Official record
Conditions
Cocaine Dependence, Alcohol Dependence
Interventions
Placebo session 1, Aprepitant session 2, Placebo session 1, Placebo session 2
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Sep 2, 2026, 5:22 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effect on Dietary Compensation and Weight Gain in Adults by Savory Solid and Sugary Liquid Discretionary Food Sources

NCT02564874
View directory record Official record
Conditions
Weight Gain
Interventions
Discretionary calorie source
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 59 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 23, 2017 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrated BA and HIV RR Counseling for MSM With Stimulant Abuse

NCT03175159
View directory record Official record
Conditions
Stimulant Abuse, HIV Prevention, Substance Abuse
Interventions
IMPACT, Standard of Care
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
205 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
2
States / cities
Miami, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1

NCT00218491
View directory record Official record
Conditions
Cocaine Dependence
Interventions
N-Acetylcysteine, Matching Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional

Effects of Nefazodone on Treatment of Female Cocaine Abusers - 3

NCT00000286
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Nefazodone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional

Carbamazepine Treatment for Cocaine Dependence - 5

NCT00000191
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Carbamazepine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 51 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1991 – 1994
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 2, 2026, 5:22 AM EDT
Completed Phase 2 Interventional

IV Cocaine Abuse: A Laboratory Model - 2

NCT00000213
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Fluoxetine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1990 – 1991
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Sep 2, 2026, 5:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Therapeutic Potential of Kappa-Opioids Against Cocaine - 1

NCT00000323
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1996 – 1998
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 2, 2026, 5:22 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence

NCT01535937
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 60 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Sep 2, 2026, 5:22 AM EDT