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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: cocoa Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors

NCT00666250
View directory record Official record
Conditions
Hypertension, Dyslipidemia, Hyperglycemia
Interventions
Xocai Activ drink
Dietary Supplement
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 95 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Cocoa Shot on the Human Brain

NCT01924481
View directory record Official record
Conditions
Caffeine, Flavonoids
Interventions
High Caffeine, Low caffeine, High theobromine, low theobromine, No theobromine
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 38 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity

NCT02490527
View directory record Official record
Conditions
Statin Intolerance
Interventions
Pure epicatechin capsules (50mg), Simvastatin (40mg), Placebo
Dietary Supplement · Drug · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
30 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Flavonoids on Gut Permeability in Cyclists

NCT03427879
View directory record Official record
Conditions
Gut Permeability, Gut Inflammation
Interventions
Low flavonoid beverage, High flavonoid beverage
Drug
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Sep 3, 2026, 4:29 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Study Assessing the Effect of Chocolate Consumption in Subjects With A History of Acne Vulgaris

NCT01193764
View directory record Official record
Conditions
Acne
Interventions
100% cocoa powder, gelatin (Gelita)
Dietary Supplement
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional

Flavanol-Rich Cocoa and Cerebral Blood Flow

NCT00825695
View directory record Official record
Conditions
Hypertension, Diabetes
Interventions
cocoa
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 29, 2014 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Daily Intake of Cocoa Flavanols and Arterial Stiffness in Humans

NCT03587883
View directory record Official record
Conditions
Healthy
Interventions
Cocoa flavanols I, Control I, Cocoa flavanols II, Control II
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated May 19, 2022 · Synced Sep 3, 2026, 4:29 PM EDT
Recruiting Phase 2Phase 3 Interventional

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

NCT05855369
View directory record Official record
Conditions
Smell Dysfunction, Olfactory Disorder, Long COVID
Interventions
Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST), Placebo Smell Training (PBO)
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Long Term Cocoa Flavanol Intake on Blood Pressure and Platelet Function in Healthy Adults, Part 2

NCT02447783
View directory record Official record
Conditions
Healthy
Interventions
Control Capsules, Mars Cocoa Extract Capsules
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
30 Years to 55 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Epicatechin-rich Cocoa on Collagen Synthesis

NCT03214133
View directory record Official record
Conditions
Collagen Synthesis
Interventions
Epicatechin-rich cocoa dose response, Epicatechin-rich cocoa vs placebo on performance
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 25 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of Raisins Versus Alternative Snacks on Cardiovascular Risk Factors In Generally Healthy Subjects

NCT01260272
View directory record Official record
Conditions
Cardiovascular Risk Factors
Interventions
Alternative Snack Comparator, Raisins
Other
Lead sponsor
Louisville Metabolic and Atherosclerosis Research Center
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 28, 2014 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Flavanols and Dentate Gyrus Function

NCT02312310
View directory record Official record
Conditions
Memory Loss
Interventions
Cocoa Flavanol
Dietary Supplement
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
50 Years to 75 Years
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 10, 2020 · Synced Sep 3, 2026, 4:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

COcoa Supplement and Multivitamin Outcomes Study for the Mind

NCT03035201
View directory record Official record
Conditions
Cognitive Impairment, Dementia, Aging
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Enrollment
2,262 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Exploratory Investigation of a B12 Vitamin to Increase Energy and Focus

NCT05517005
View directory record Official record
Conditions
B12 Deficiency Vitamin, Energy Supply; Deficiency, Mood
Interventions
Hype Bites Supplement
Dietary Supplement
Lead sponsor
Sourse
Industry
Eligibility
24 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Dark Chocolate (70% Cacao) on EEG Brain Waves in Vigorously Active Individuals

NCT03203824
View directory record Official record
Conditions
Healthy
Interventions
dark chocolate, non dark chocolate
Dietary Supplement · Other
Lead sponsor
Loma Linda University
Other
Eligibility
21 Years to 45 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 24, 2018 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Protein Source on Appetite Control, Satiety, and Subsequent Food Intake: A Clinical Screening Study

NCT03595436
View directory record Official record
Conditions
Appetitive Behavior
Interventions
Pea Protein-20g, Pea Protein-30g, Pea Protein-40g, Whey Protein-20g, Carbohydrate Control
Dietary Supplement
Lead sponsor
Purdue University
Other
Eligibility
20 Years to 40 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pre- and Post-restriction Chocolate Candy Consumption

NCT02003950
View directory record Official record
Conditions
Investigate the Maladaptive Eating Behaviors of Normal Healthy Adults
Interventions
Snack Condition Specification
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Effect of Vitamin D Statues on Endothelial Function

NCT01049048
View directory record Official record
Conditions
Cardiovascular Diseases, Vitamin D Deficiency
Interventions
Vitamin D3, Placebo
Dietary Supplement
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
55 Years to 65 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 4, 2015 · Synced Sep 3, 2026, 4:29 PM EDT
Completed No phase listed Observational

Cocoa, Polyphenols, and the Kidney in Healthy Subjects and in Subjects With Hypertension and Diabetes Mellitus

NCT00639665
View directory record Official record
Conditions
Diabetes
Interventions
Cocoa
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2015 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional

Effect of High-Dose Guarana And Cancer-Related Fatigue

NCT03897556
View directory record Official record
Conditions
Cancer-related Fatigue
Interventions
Guarana herb, Usual Care
Dietary Supplement · Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Fasting Mimicking Diet

NCT04150159
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
FMD Arm
Dietary Supplement
Lead sponsor
Hypertension Institute, Nashville
Other
Eligibility
35 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intake-dependent Effect of Cocoa Flavanol Absorption, Metabolism and Excretion in Humans

NCT03201822
View directory record Official record
Conditions
Healthy
Interventions
100 mg of Cocoa Flavanols/70 kg BW, 200 mg of Cocoa Flavanols/70 kg BW, 400 mg of Cocoa Flavanols/70 kg BW, 1000 mg of Cocoa Flavanols/70 kg BW
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 40 Years · Male only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Sep 3, 2026, 4:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nudging for Behavior Change in School Cafeterias

NCT04156542
View directory record Official record
Conditions
Behavior, Child, Food Selection
Interventions
Basic School Lunchroom Nudges
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
10 Years to 15 Years
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
6
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 6, 2019 · Synced Sep 3, 2026, 4:29 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application

NCT02758990
View directory record Official record
Conditions
Obesity, Rhinitis, Rhinitis, Allergic, Respiratory Sounds, Dyspnea, Headache, Migraine Disorders, Arthritis, Arthralgia, Anxiety, Sleep Initiation and Maintenance Disorders, Sleep Deprivation
Interventions
Vitamin A, Vitamin B6, Vitamin C, Nicotinamide, Vitamin D3, Vitamin E, Broccoli, Spinach, Caffeine, Coffee, Axon Eyewear, Chocolate
Dietary Supplement · Other · Device
Lead sponsor
Verifomics LLC
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2017 · Synced Sep 3, 2026, 4:29 PM EDT