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ClinicalTrials.gov public records Last synced Oct 22, 2026, 4:15 PM EDT

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Showing 49–72 of 144 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: cocoa Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity

NCT02490527
View directory record Official record
Conditions
Statin Intolerance
Interventions
Pure epicatechin capsules (50mg), Simvastatin (40mg), Placebo
Dietary Supplement · Drug · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
30 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 22, 2026, 4:15 PM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Natural Heart Health Supplement Trial

NCT06671769
View directory record Official record
Conditions
Cholesterol, Cholesterol (total and HDL)
Interventions
Heart Health Supplement
Dietary Supplement
Lead sponsor
Efforia, Inc
Industry
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 4, 2024 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Chewing Gum on a Computer Task and Liking Ratings of Ice Cream

NCT02198911
View directory record Official record
Conditions
Habituation
Interventions
NO GUM, MCC (Mint Chocolate Chip gum), C (Cinnamon gum)
Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional

Effect of Revival Soy on Fibromyalgia Pain

NCT00279942
View directory record Official record
Conditions
Fibromyalgia
Interventions
Soy, Placebo
Dietary Supplement · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 76 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 6, 2012 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Dark Chocolate (70% Cacao) on EEG Brain Waves in Vigorously Active Individuals

NCT03203824
View directory record Official record
Conditions
Healthy
Interventions
dark chocolate, non dark chocolate
Dietary Supplement · Other
Lead sponsor
Loma Linda University
Other
Eligibility
21 Years to 45 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating the Effects of Cocoa Flavanol on Cognition Assessed Online

NCT04582617
View directory record Official record
Conditions
Aging, Cognitive Change
Interventions
Cocoa Extract, Cocoa Extract Placebo, Multivitamin, Multivitamin placebo
Dietary Supplement
Lead sponsor
Columbia University
Other
Eligibility
65 Years and older
Enrollment
3,959 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2023 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans

NCT03194620
View directory record Official record
Conditions
Healthy
Interventions
Thearubigins, Theaflavins, Procyanidin Dimer B2 (DB2), (-)-Epigallocatechin-3-O-gallate (EGCG), (-)-Epicatechin-3-O-gallate (ECG), (-)-Epicatechin (EC), (-)-Epigallocatechin (EGC), Control
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 60 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Long Term Cocoa Flavanol Intake on Blood Pressure and Platelet Function in Healthy Adults, Part 1

NCT02447770
View directory record Official record
Conditions
Healthy
Interventions
Mars Cocoa Extract Capsules
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
30 Years to 55 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional

Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Obesity and HFpEF

NCT03966755
View directory record Official record
Conditions
Obesity, Heart Failure With Normal Ejection Fraction
Interventions
UFA dietary recommendations
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional

Expanded Quantitative Urinary Culture (EQUC) vs Standard Culture (SUC) Techniques in the Clinical Care

NCT03190421
View directory record Official record
Conditions
Urinary Tract Infections
Interventions
Expanded Urinary Culture, Standard Urine Culture (SUC)
Diagnostic Test
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older · Female only
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Role of Flavanols In Cardiovascular Function in Healthy Aging

NCT01395277
View directory record Official record
Conditions
Aging
Interventions
High Flavanol first then Low Flavanol, Low Flavanol first then High Flavanol
Dietary Supplement
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 10, 2015 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Soft Tissue Therapy and Exercise on Hamstring Tightness

NCT03651141
View directory record Official record
Conditions
Hamstring Tightness, Myofascial Pain, Musculoskeletal Pain
Interventions
Neurodynamic Sliding, Myofascial Decompression, Diathermy
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 25 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Exercise on Chocolate Addiction

NCT03356509
View directory record Official record
Conditions
Acute Exercise and Addictive Behavior
Interventions
Exercise
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Phase 2 Interventional Results available

Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation

NCT01319110
View directory record Official record
Conditions
Cardiac Arrest, Sudden Cardiac Arrest
Interventions
Coenzyme Q10, Placebo
Drug · Dietary Supplement
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Cocoa Shot on the Human Brain 2

NCT02080845
View directory record Official record
Conditions
Caffeine
Interventions
no caffeine, high caffeine, no theobromine, low theobromine, high theobromine
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2018 · Synced Oct 22, 2026, 4:15 PM EDT
Recruiting Phase 1 Interventional

Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.

NCT07347405
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Psilocybin 10 mg, Psilocybin 20 mg, Psilocybin 30 mg
Drug
Lead sponsor
Francisco A Moreno
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 22, 2026, 4:15 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Chicory Fiber Effect on Satiety and GI Tolerance

NCT04067362
View directory record Official record
Conditions
Diet, Healthy
Interventions
food containing dietary fiber
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 22, 2026, 4:15 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Cocoa-rich Bioflavanol Supplementation Effects During Cold Exposure

NCT04359082
View directory record Official record
Conditions
Cold Exposure, Manual Dexterity, Gut Microbiome
Interventions
CocoaVia supplement, Placebo Pill
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 49 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2021 · Synced Oct 22, 2026, 4:15 PM EDT
Recruiting Phase 2Phase 3 Interventional

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

NCT05855369
View directory record Official record
Conditions
Smell Dysfunction, Olfactory Disorder, Long COVID
Interventions
Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST), Placebo Smell Training (PBO)
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 22, 2026, 4:15 PM EDT
Withdrawn Not applicable Interventional

Understanding Angioplasty by the Chocolate PTA Balloon Catheter Compared to Conventional PTA Balloons Via OCT Imaging

NCT02237066
View directory record Official record
Conditions
Infrainguinal Peripheral Arterial Disease
Interventions
Chocolate PTA Balloon Angioplasty, Standard PTA Balloon Angioplasty
Device
Lead sponsor
TriReme Medical, LLC
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2015 · Synced Oct 22, 2026, 4:15 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

COcoa Supplement and Multivitamin Outcomes Study: Effects on Falls and Physical Performance

NCT05232669
View directory record Official record
Conditions
Fall, Physical Performance, Fracture
Interventions
Cocoa extract, Cocoa extract placebo, Multivitamin, Multivitamin placebo
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
60 Years and older
Enrollment
21,442 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Protein Timing and Resistance Exercise on Fat Metabolism

NCT03573687
View directory record Official record
Conditions
Healthy
Interventions
Micellar Casein Protein, Resistance Exercise Training
Dietary Supplement · Other
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jul 6, 2018 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intake-dependent Effect of Cocoa Flavanol Absorption, Metabolism and Excretion in Humans

NCT03201822
View directory record Official record
Conditions
Healthy
Interventions
100 mg of Cocoa Flavanols/70 kg BW, 200 mg of Cocoa Flavanols/70 kg BW, 400 mg of Cocoa Flavanols/70 kg BW, 1000 mg of Cocoa Flavanols/70 kg BW
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 40 Years · Male only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2017 · Synced Oct 22, 2026, 4:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Unique Lipids From Almonds

NCT05782218
View directory record Official record
Conditions
Nutrition, Healthy
Interventions
Almonds, Coconut
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 22, 2026, 4:15 PM EDT