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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:44 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 61 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: computerized cognitive remediation Clear all

Conditions: Post-Acute COVID-19 Syndrome
Interventions: NeuroFlex (computerized gamified tasks); Other
Lead sponsor: UConn Health; Other
Eligibility: 60 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Depression Mild, Depressive Disorder, Major, Mild Cognitive Impairment
Interventions: Computerized Cognitive Remediation of Executive Functioning (CCR-EF), Active Control; Other
Lead sponsor: UConn Health; Other
Eligibility: 60 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Multiple Sclerosis
Interventions: PACR (Plasticity-based, Adaptive, Computerized Cognitive Remediation); Other
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 136 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Aging, Depression, Cognitive Symptom
Interventions: Cognitive Training, tDCS (active stimulation), tDCS (sham stimulation); Behavioral · Device
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Schizophrenia
Interventions: Plasticity-based Cognitive Training, Non-plasticity-based Training; Other
Lead sponsor: Posit Science Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 2
States / cities: Palo Alto, California • San Francisco, California

Conditions: Breast Cancer
Interventions: Brain Fitness Program (BFP); Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 70 Years · Female only
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: Cognitive Remediation, Computer Games; Behavioral
Lead sponsor: Wesleyan University; Other
Eligibility: 18 Years and older
Enrollment: 135 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Hartford, Connecticut • Middletown, Connecticut

Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: Computerized Cognitive Skill Training, CRT and Social Cognition; Behavioral
Lead sponsor: Nathan Kline Institute for Psychiatric Research; Other
Eligibility: 18 Years and older
Enrollment: 448 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: HIV, Aging
Interventions: transcranial direct current stimulation (tDCS); Device
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 50 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder
Interventions: Cognitive training, Aerobic Exercise Program, Moderated Online Social Therapy (MOST), Chorus Participatory Text Messaging Program, Healthy Living Group (HLG); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 45 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Schizophrenia, Schizoaffective Disorder, Chronic Mental Disorder, Major Depression, Bipolar Disorder
Interventions: The Thinking Skills for Work Program, The Cognitive Skills for Work Program; Behavioral
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years and older
Enrollment: 203 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2019
U.S. locations: 2
States / cities: Chicago, Illinois • Manchester, New Hampshire

Conditions: Cognitive Impairment, Schizophrenia
Interventions: Cognitive Rehabilitation Therapy (CRT) + Skill Training (SDG), Individual Computer Based Cognitive Rehabilitation (ICBCR) and Skills Training (SDG), Skills Group (SDG); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Aging, Inflammation, Cognitive Remediation, Cognitive Dysfunction, Postviral Syndrome, Digital Medicine
Interventions: Computerized Cognitive Remediation, Alternative Computer Activities; Other
Lead sponsor: Cutter Lindbergh; Other
Eligibility: 60 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Mobility Limitation, Motor Activity, Difficulty Walking, Cognitive Ability General
Interventions: Cognitive Remediation, Active Control; Other
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 70 Years and older
Enrollment: 383 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Multiple Sclerosis, Cognitive Deficits, Gilenya Modifying Therapy for MS
Interventions: plasticity-based computerized cognitive remediation program, Gileyna; Other · Drug
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Schizophrenia
Interventions: Cognitive remediation training (CT), Healthy behavior training (HBT), Risperidone, administered orally (Oral Ris), Risperidone, administered via injection (RLAI); Behavioral · Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 45 Years
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Schizophrenia, Schizoaffective Disorder, Major Depression, Bipolar Disorder, Anxiety Disorder
Interventions: Thinking Skills for Work Program, Supported Employment; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 2
States / cities: Chicago, Illinois • Manchester, New Hampshire

Conditions: Older Adults, Aging Brain
Interventions: Computerized Plasticity-based Software, Commercially available Video Game; Behavioral
Lead sponsor: Posit Science Corporation; Industry
Eligibility: 65 Years to 79 Years
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Multiple Sclerosis, Cognitive Impairment
Interventions: Computerized cognitive rehabilitation, Sham placebo; Other
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Chronic Schizophrenia
Interventions: Cognitive remediation therapy, COMT Genotyping; Behavioral · Genetic
Lead sponsor: Manhattan Psychiatric Center; Other
Eligibility: 18 Years to 55 Years
Enrollment: 142 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2016
U.S. locations: 1
States / cities: Wards Island, New York

Conditions: Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder
Interventions: Case management and supportive psychotherapy, Family psychoeducation, Cognitive training, Aerobic exercise; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 45 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: Sensory Information Processing Training, Active Control Training; Behavioral
Lead sponsor: VA Connecticut Healthcare System; Federal
Eligibility: 18 Years to 60 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: MCI, Subjective Cognitive Decline (SCD), Mild Behavioral Impairment
Interventions: Cognitive Remediation, Cognitive Remediation II; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 60 Years to 89 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Traumatic Brain Injury
Interventions: Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training; Other
Lead sponsor: Posit Science Corporation; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

Brain-Training Treatment for Long COVID in Older Adults

Cognitive Fitness for Depression in Older Adults

Computerized Cognitive Exercise Training Treatment for Adults With Multiple Sclerosis

Cognitive Enhancement in Depression (The COG-D Study)

Evaluation of a Cognitive Adaptive E-treatment in Schizophrenia-diagnosed Adults

An Investigation of Chemotherapy Induced Cognitive Impairments in Breast Cancer Survivors

Comparing Cognitive Remediation Approaches for Schizophrenia

Cognitive Skills Training Using Computer for Patients With Severe Mental Illness

A Novel Neurorehabilitation Approach for Cognitive Aging With HIV

Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode

Understanding How Cognitive Remediation Works

Cognitive Rehabilitation in Schizophrenia

Cognitive Remediation

Cognitive Remediation to Improve Mobility in Sedentary Seniors

Computerized Exercise Training for Cognitive Remediation in Adults With Multiple Sclerosis Treated With Gilenya

Psychosocial Therapy and Risperidone Treatment in Work Performance in Recent-Onset Schizophrenia

Thinking Skills for Work in Severe Mental Illness

Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

Computerized Cognitive Rehabilitation in MS Patients

Relation of Catechol-O-methyltransferase (COMT) Genotype and Response to Cognitive Remediation Schizophrenia

Enhancing Cognitive Training Through Exercise After a First Schizophrenia Episode

Perceptual Deficits in Schizophrenia

FACE Phase II (a Stage II Trial)

Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury