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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: constraint-induced movement therapy Clear all
Not listed Phase 2 Interventional

Constraint-Based Therapy to Improve Motor Function in Children With Cerebral Palsy

NCT00061139
View directory record Official record
Conditions
Cerebral Palsy, Motor Deficits
Interventions
Pediatric Constraint-Induced Movement therapy, Conventional pediatric motor rehabilitation therapy
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 6 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional Results available

Brain Stimulation and Hand Training in Children With Hemiparesis

NCT02250092
View directory record Official record
Conditions
Pediatric Hemiparesis
Interventions
Transcranial Direct Current Stimulation (tDCS), Placebo Comparator
Device
Lead sponsor
University of Minnesota
Other
Eligibility
8 Years to 21 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient

NCT01143649
View directory record Official record
Conditions
Stroke, Healthy
Interventions
transcranial direct current stimulation (tDCS), constraint induced movement therapy (CIMT), transcranial alternating current stimulation (tACS)
Device · Procedure
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 19, 2026, 7:35 PM EDT
Completed No phase listed Observational

Infant Modified Constraint Induced Movement Therapy Paired With Neuromuscular Electrical Stimulation: a Case Series

NCT05134272
View directory record Official record
Conditions
Hemiplegia, Cerebral Palsy, Unilateral Cerebral Palsy
Interventions
Neuromuscular electrical stimulation, Modified constraint induced movement therapy, Standard care for infant with asymmetrical hand function
Device · Behavioral
Lead sponsor
Kathy Grinde
Other
Eligibility
7 Months to 10 Months
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Maple Grove, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional

Comparing CIMT With Virtual Reality to CIMT

NCT06506682
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Constraint Induced Movement Therapy, CIMT + VR
Behavioral
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
5 Years to 16 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional

tDCS and Physical Therapy in Stroke

NCT00542256
View directory record Official record
Conditions
Cerebrovascular Accident
Interventions
Active transcranial Direct Current Stimulation / Constraint Induced Movement Therapy, Sham transcranial Direct Current Stimulation / Constraint Induced Movement Therapy
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Sep 19, 2026, 7:35 PM EDT
Withdrawn Not applicable Interventional

Cerebral pAlsy Motor Promotion With Transcranial Direct Current Stimulation (CAMP-tDCS)

NCT06239675
View directory record Official record
Conditions
Cerebral Palsy, Hemiplegic
Interventions
tDCS, CIMT, sham tDCS
Device · Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
5 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 19, 2026, 7:35 PM EDT
Not listed Phase 2 Interventional

Improving Hand Use in Multiple Sclerosis

NCT01081275
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
CI Therapy, CAM treatments
Behavioral
Lead sponsor
National Multiple Sclerosis Society
Other
Eligibility
21 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Phase 1 Interventional

Constraint-Induced (CI) Movement Therapy for Progressive Multiple Sclerosis (MS)

NCT00695084
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Constraint-Induced Movement Therapy
Behavioral
Lead sponsor
National Multiple Sclerosis Society
Other
Eligibility
21 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 10, 2008 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional

Camp High 5: Evaluation of the Effect on Upper Limb Function

NCT02875054
View directory record Official record
Conditions
Neurological Injury, Hemiplegia
Interventions
Constraint induced movement therapy (CIMT), Hand-arm bimanual intensive training (HABIT)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
2 Years to 12 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Phase 2 Interventional Results available

Transcranial Direct Current Stimulation for Post-stroke Motor Recovery

NCT03826030
View directory record Official record
Conditions
Stroke, Ischemic, Motor Activity, Upper Extremity Paralysis
Interventions
Sham, Low dose tDCS, High dose tDCS, mCIMT
Device · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
14
States / cities
Birmingham, Alabama • Los Angeles, California • Washington D.C., District of Columbia + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 19, 2026, 7:35 PM EDT
Recruiting Not applicable Interventional

Constraint-Induced Movement Therapy Plus Sensory Components After Stroke

NCT05515237
View directory record Official record
Conditions
CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
Interventions
Grade 2-5 CI Therapy + Sensory Components
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bimanual Training in Children With Hemiplegia

NCT01413594
View directory record Official record
Conditions
Hemiplegia, Cerebral Palsy, Children
Interventions
HABIT
Behavioral
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
18 Months to 16 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 18, 2021 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional

Use of Vibration During Constraint-induced Movement Therapy

NCT06452576
View directory record Official record
Conditions
Hemiparesis
Interventions
Vibration, constraint-induced movement therapy
Device · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
4 Years to 9 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 6, 2025 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional

Feasibility of Pediatric CIMT by Televideo

NCT05303883
View directory record Official record
Conditions
Hemiplegic Cerebral Palsy
Interventions
Pediatric Constrained Induced Movement Therapy
Other
Lead sponsor
Ohio State University
Other
Eligibility
1 Year to 10 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
3
States / cities
Columbus, Ohio • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Novel Brain Stimulation Therapies in Stroke Guided Expressions of Plasticity

NCT03020433
View directory record Official record
Conditions
Stroke, Cerebrovascular Disorders, Nervous System Diseases, Brain Diseases, Cardiovascular Diseases, Vascular Diseases, Central Nervous System Diseases
Interventions
rTMS Contralesional M1, rTMS Contralesional PMC, rTMS Ipsilesional PMC, rTMS sham at Ipsilesional M1
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
21 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Sep 19, 2026, 7:35 PM EDT
Recruiting Not applicable Interventional

Self-Supervised Constraint-Induced Movement Therapy for Stroke Recovery

NCT07723300
View directory record Official record
Conditions
Stroke, Stroke (CVA) or TIA, Cerebral Vascular Accident (CVA)/Stroke
Interventions
Self-Supervised Constraint-Induced Movement Therapy (sCIMT)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Phase 2 Interventional Results available

Improving Stroke Rehabilitation: Spacing Effect and D-cycloserine

NCT00720759
View directory record Official record
Conditions
Stroke
Interventions
D-cycloserine + distributed treatment, D-cycloserine + condensed treatment, Placebo + distributed treatment, Placebo + condensed treatment
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
20 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 6, 2014 · Synced Sep 19, 2026, 7:35 PM EDT
Not listed Not applicable Interventional

Combined Constraint Therapy and Bimanual Therapy for Children With Unilateral Brain Injury

NCT02840643
View directory record Official record
Conditions
Hemiplegia, Cerebral Palsy
Interventions
Bimanual hand therapy, Constraint therapy
Behavioral
Lead sponsor
Blythedale Children's Hospital
Other
Eligibility
4 Years to 17 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2023
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2022 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Early Phase 1 Interventional Results available

CIMT and taVNS for Hemiplegia in Infants

NCT05101707
View directory record Official record
Conditions
Infant Development, Hemiplegia, Constraint Induced Movement Therapy
Interventions
transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
6 Months to 18 Months
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional

Implementation of Therapy Together With Early Childhood Intervention

NCT06853717
View directory record Official record
Conditions
Unilateral Cerebral Palsy
Interventions
Therapy Together
Behavioral
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
3 Months to 3 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Denton, Texas
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Early Phase 1 Interventional Results available

Extending taVNS Paired With Infant CIMT Into a Home-Based Setting

NCT05857527
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Custom EMG triggered Soterix taVNS stimulation with CIMT therapy in lab, Custom EMG triggered Soterix taVNS stimulation with CIMT therapy in home
Combination Product
Lead sponsor
Medical University of South Carolina
Other
Eligibility
6 Months to 18 Months
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Sep 19, 2026, 7:35 PM EDT
Completed Not applicable Interventional Results available

Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia

NCT02918890
View directory record Official record
Conditions
Cerebral Palsy, Hemiplegia, Children
Interventions
Constraint-induced Movement Therapy, Hand-arm Bimanual Intensive Therapy
Other
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
6 Years to 17 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 19, 2026, 7:35 PM EDT
Withdrawn Phase 2 Interventional

RCT of a Neuroplasticity Agent and CI Therapy for Severe Arm Paresis After Stroke

NCT01963832
View directory record Official record
Conditions
Severe Stroke With Affected Arm Motor Function
Interventions
Fluoxetine, Placebo, eCMIT, Usual Care
Drug · Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
40 Years and older · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 11, 2015 · Synced Sep 19, 2026, 7:35 PM EDT