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ClinicalTrials.gov public records Last synced Oct 24, 2026, 7:33 AM EDT

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Showing 1–24 of 78 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: dim light Clear all
Completed Not applicable Interventional Results available

Feasibility of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors

NCT02954809
View directory record Official record
Conditions
Fatigue, Sleep Disturbance, Circadian Dysregulation
Interventions
Morning bright light therapy, Dim light
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2

NCT03464084
View directory record Official record
Conditions
Glucose, Circadian Rhythm, Melatonin, Genes, Light
Interventions
placebo, melatonin, bright light, dim light
Drug · Dietary Supplement · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Oct 24, 2026, 7:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

NCT06104280
View directory record Official record
Conditions
Opioid Use Disorder, Sleep Disturbance
Interventions
Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test, Ecological Momentary Assessments, Actigraphy, DLMO, Melatonin Suppression Test
Other · Behavioral · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 24, 2026, 7:33 AM EDT
Recruiting Not applicable Interventional

Bright Light Exposure in Surgical Patients

NCT03822949
View directory record Official record
Conditions
Myocardial Ischemia, Critical Illness, Endothelial Dysfunction
Interventions
Day Light, Placebo light, ICU Intense Light, ICU Placebo light
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 90 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 24, 2026, 7:33 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders

NCT00387179
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Melatonin, Methylxanthine, Light Therapy
Drug · Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 25, 2009 · Synced Oct 24, 2026, 7:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults

NCT04396002
View directory record Official record
Conditions
Primary Open Angle Glaucoma
Interventions
Life Space Questionnaire, Low Luminance Questionnaire, Contrast sensitivity under dim illumination, Visual field under dim illumination (MAIA), Macular Pigment Optical Density (MPOD), Dark Adaptation
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment

NCT05411822
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Lighting Intervention Blue light, Lighting Intervention Green light, Dim-light control condition
Device · Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
55 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Menands, New York
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Oct 24, 2026, 7:33 AM EDT
Recruiting Not applicable Interventional

Circadian Light Exposure Adjustment for Restfulness

NCT07391852
View directory record Official record
Conditions
Sleep Onset Latency
Interventions
Amber Tinted Glasses, Clear Glasses, Smart Lightbulbs
Device
Lead sponsor
University of Arizona
Other
Eligibility
60 Months to 83 Months
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Results available

Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy

NCT01725750
View directory record Official record
Conditions
Traumatic Brain Injury, Fatigue
Interventions
Bright White Light (BWL), Dim Red Light (DRL)
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Oct 24, 2026, 7:33 AM EDT
Withdrawn Not applicable Interventional

Light Therapy to Treat Depression in Pediatric Stem Cell Therapy Recipients

NCT06496477
View directory record Official record
Conditions
Hematopoietic Stem Cell Transplant
Interventions
Ayo wearable
Device
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
8 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 24, 2026, 7:33 AM EDT
Not yet recruiting Not applicable Interventional

SmartEnLite for Nursing Home Residents With Dementia

NCT07883291
View directory record Official record
Conditions
Alzheimer's Disease and Related Dementias, Alzheimer Disease and Related Dementias
Interventions
Smart Environmental Light (SmartEnLite)
Device
Lead sponsor
Penn State University
Other
Eligibility
55 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Results available

Relaxing Environment to Lower Anxiety During Onabotulinum Toxin Chemodenervation of the Bladder

NCT06319898
View directory record Official record
Conditions
Anxiety, Pain, Burnout, Professional
Interventions
Lavender aromatherapy sticker
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional

Adjunctive Bright Light Therapy for Opioid Use Disorder

NCT05459922
View directory record Official record
Conditions
Opioid Use Disorder, Sleep Disturbance
Interventions
Wearable bright light therapy device, Wearable placebo light therapy device
Device
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Phase 3 Interventional Results available

Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial

NCT00852592
View directory record Official record
Conditions
Bipolar Disorder, Major Depressive Episode
Interventions
7000lux broad-spectrum light, 50lux dim red light
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Oct 24, 2026, 7:33 AM EDT
Recruiting Phase 2 Interventional

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

NCT06226025
View directory record Official record
Conditions
Bipolar Disorder, Delayed Sleep-Wake Phase Disorder
Interventions
Melatonin, Placebo, Behavioral sleep intervention, Behavioral sleep control
Drug · Other · Behavioral
Lead sponsor
Leslie Swanson
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction

NCT04868539
View directory record Official record
Conditions
Glucose Intolerance, Sleep Deprivation, Sleep
Interventions
Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 40 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Toileting at Night in Older Adults: Light to Maximize Balance, Minimize Insomnia

NCT01350505
View directory record Official record
Conditions
Falls, Balance, Insomnia, Aging
Interventions
White light exposure, Dim white light exposure, Very dim white light exposure, Dim orange light exposure
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years to 85 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 15, 2019 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Results available

Morning Light Treatment at Home to Reduce PTSD Symptoms

NCT03513848
View directory record Official record
Conditions
PTSD
Interventions
Retimer, Retimer placebo
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2019 · Synced Oct 24, 2026, 7:33 AM EDT
Active, not recruiting Not applicable Interventional

Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease

NCT02909192
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Light Therapy Device
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 24, 2026, 7:33 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Light at Night Study

NCT04251234
View directory record Official record
Conditions
Bipolar Disorder, Light Sensitivity
Interventions
Light intensity, ~30 lux, Baseline light intensity, <1 lux
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 12, 2021 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Individually Tailored Lighting System to Improve Sleep in Older Adults

NCT01855126
View directory record Official record
Conditions
Sleep Disturbances
Interventions
Blue light, Red light
Other
Lead sponsor
Rensselaer Polytechnic Institute
Other
Eligibility
65 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Troy, New York
Source: ClinicalTrials.gov public record
Updated Jan 29, 2019 · Synced Oct 24, 2026, 7:33 AM EDT
Completed Not applicable Interventional

Audio-visual Stimulation: Sleep Dose Response

NCT03569865
View directory record Official record
Conditions
Insomnia Chronic, Osteoarthritis, Pain, Chronic
Interventions
Audiovisual Stimulation
Device
Lead sponsor
University of Washington
Other
Eligibility
60 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Oct 24, 2026, 7:33 AM EDT
Enrolling by invitation Phase 2 Interventional

Bright Light Therapy for Depressed Geriatric Inpatients

NCT07002554
View directory record Official record
Conditions
Unipolar Depression
Interventions
Bright light therapy, dim red light
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 24, 2026, 7:33 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep

NCT07753889
View directory record Official record
Conditions
Circadian Rhythm, Pupillometry, Sleep
Interventions
Ocular light exposure from portable light box
Other
Lead sponsor
Elizabeth B Klerman MD PhD
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2035
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 24, 2026, 7:33 AM EDT