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ClinicalTrials.gov public records Last synced Oct 24, 2026, 9:46 PM EDT

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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: disulfiram Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Disulfiram Interactions With HIV Medications: Clinical Implications

NCT00878306
View directory record Official record
Conditions
HIV Infections, Drug Abuse
Interventions
Disulfiram, Disulfiram + Efavirenz, Disulfiram + Atazanavir, Disulfiram + Ritonavir
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 6, 2014 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 4 Interventional Results available

Neural Mechanisms of Disulfiram Effects

NCT02735577
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Disulfiram
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Oct 24, 2026, 9:46 PM EDT
Recruiting Phase 1Phase 2 Interventional

Disulfiram for Treatment of Retinal Degeneration

NCT05626920
View directory record Official record
Conditions
Inherited Retinal Dystrophy Primarily Involving Sensory Retina
Interventions
Disulfiram 250 mg, Placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 2 Interventional Results available

Pharmacogenetics of Disulfiram for Cocaine

NCT00149630
View directory record Official record
Conditions
Cocaine Dependence, Opioid Dependence
Interventions
Disulfiram, Methadone, CBT, Lactose
Drug · Behavioral · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 15, 2017 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone

NCT00218608
View directory record Official record
Conditions
Cocaine-Related Disorders, Opioid-Related Disorders
Interventions
Disulfiram
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 31, 2012 · Synced Oct 24, 2026, 9:46 PM EDT
Terminated Phase 1 Interventional

A Phase Ib Study of Intravenous Copper Loading With Oral Disulfiram in Metastatic, Castration Resistant Prostate Cancer

NCT02963051
View directory record Official record
Conditions
Prostate Cancer
Interventions
Copper, Disulfiram, Copper gluconate
Drug
Lead sponsor
Daniel George, MD
Other
Eligibility
18 Years and older · Male only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 2 Interventional

Disulfiram for Cocaine Abuse in Buprenorphine Treatment

NCT00913484
View directory record Official record
Conditions
Cocaine Dependence, Opioid Dependency
Interventions
Disulfiram, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 19, 2020 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Not applicable Interventional Results available

Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals

NCT01286259
View directory record Official record
Conditions
HIV-1 Infection
Interventions
Disulfiram
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
San Francisco, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Oct 24, 2026, 9:46 PM EDT
Terminated Phase 1 Interventional

Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma

NCT04521335
View directory record Official record
Conditions
Multiple Myeloma
Interventions
Disulfiram, Copper Gluconate
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 13, 2023 · Synced Oct 24, 2026, 9:46 PM EDT
Recruiting Phase 1 Interventional

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

NCT05210374
View directory record Official record
Conditions
Relapsed Sarcomas
Interventions
Disulfiram, Copper Gluconate, Liposomal Doxorubicin (Doxil)
Drug
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 24, 2026, 9:46 PM EDT
Terminated No phase listed Observational

Promoting Medications for Alcohol Use Disorder on the General Medicine Service

NCT04287790
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
audit and feedback, educational meetings, and academic detailing to promote medication receipt, Acamprosate, naltrexone, or disulfiram
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma

NCT02715609
View directory record Official record
Conditions
Glioblastoma Multiforme
Interventions
Disulfiram, Copper Gluconate, Surgery, Radiation, Temozolomide
Drug · Procedure · Radiation
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Not applicable Interventional

Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers

NCT00580827
View directory record Official record
Conditions
Cocaine-Related Disorder, Opiate Dependence
Interventions
Placebo, Disulfiram
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 31, 2020 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 1Phase 2 Interventional Results available

A Study of the Relationship Between Disulfiram and Cocaine Self-administration.

NCT00729300
View directory record Official record
Conditions
Cocaine Addiction
Interventions
placebo, disulfiram
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Oct 24, 2026, 9:46 PM EDT
Terminated Phase 2 Interventional Results available

Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme

NCT03363659
View directory record Official record
Conditions
Glioblastoma, Glioblastoma Multiforme
Interventions
Disulfiram, Copper gluconate, Temozolomide
Drug · Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Short-term Disulfiram Administration to Reverse Latent HIV Infection: a Dose Escalation Study

NCT01944371
View directory record Official record
Conditions
HIV, Human Immunodeficiency Virus
Interventions
Disulfiram
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 5, 2020 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

CBT With Disulfiram and Contingency Management

NCT00350870
View directory record Official record
Conditions
Cocaine Abuse
Interventions
disulfiram, Placebo, Placebo plus Contingency Management, Disulfiram plus Contingency Management
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Not applicable Interventional Results available

Study of Recurrent Prostate Cancer With Rising Prostate Specific Antigen (PSA)

NCT01118741
View directory record Official record
Conditions
Prostate Cancer
Interventions
Disulfiram
Drug
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older · Male only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
3
States / cities
Baltimore, Maryland • Durham, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 12, 2018 · Synced Oct 24, 2026, 9:46 PM EDT
Recruiting Not applicable Interventional

Combining a Smartphone App With Medications to Manage Heavy Drinking

NCT06303778
View directory record Official record
Conditions
Alcohol Use Disorder (AUD)
Interventions
Stand Down mobile app, Standard Care
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
15
States / cities
Phoenix, Arizona • Fayetteville, Arkansas • Washington D.C., District of Columbia + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 24, 2026, 9:46 PM EDT
Terminated Phase 1 Interventional

Disulfiram and Chemotherapy in Treating Patients With Refractory Solid Tumors or Metastatic Pancreatic Cancer

NCT02671890
View directory record Official record
Conditions
Metastatic Pancreatic Adenocarcinoma, Refractory Malignant Solid Neoplasm, Stage IV Pancreatic Cancer AJCC v8
Interventions
Chemotherapy, Disulfiram, Gemcitabine Hydrochloride, Laboratory Biomarker Analysis
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
2
States / cities
Rochester, Minnesota • Thief River Falls, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Oct 24, 2026, 9:46 PM EDT
Terminated Phase 2 Interventional Results available

DISulfiram for COvid-19 (DISCO) Trial

NCT04485130
View directory record Official record
Conditions
Covid19
Interventions
Disulfiram, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Fresno, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Open Label Pilot Study of Perampanel for the Treatment of Alcohol Use Disorder

NCT04502589
View directory record Official record
Conditions
Alcohol Disorders
Interventions
Perampanel Tablet, Disulfiram
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2022 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 1Phase 2 Interventional

Disulfiram in Patients With Metastatic Melanoma

NCT00256230
View directory record Official record
Conditions
Stage IV Melanoma
Interventions
Disulfiram (DSF)
Drug
Lead sponsor
John P. Fruehauf
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Dec 8, 2016 · Synced Oct 24, 2026, 9:46 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Disulfiram for Cocaine Abuse

NCT00395850
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Disulfiram
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Nov 13, 2013 · Synced Oct 24, 2026, 9:46 PM EDT