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ClinicalTrials.gov public records Last synced Oct 20, 2026, 7:02 AM EDT

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Showing 1–24 of 437 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: e-Cigarette Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping

NCT07009509
View directory record Official record
Conditions
Nicotine Vaping
Interventions
YES-CAN! program
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
9 Years and older
Enrollment
1,166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Phase 3 Interventional

Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers

NCT06435221
View directory record Official record
Conditions
Smoking Cessation, Vaping Cessation
Interventions
Cytisinicline
Drug
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
29
States / cities
Mobile, Alabama • Tempe, Arizona • Little Rock, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Adolescent Inpatient Tobacco and ENDS Intervention

NCT05936099
View directory record Official record
Conditions
Vaping, Smoking
Interventions
E-cigarette & Tobacco Use Treatment Intervention
Behavioral
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
14 Years to 21 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine

NCT05994703
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
d-cycloserine, Juul e-cigarette
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes

NCT03856515
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
Drug · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years and older
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Results available

Quit or Switch: E-cigarette Study

NCT05525078
View directory record Official record
Conditions
Tobacco Use
Interventions
e-cigarette, Nicotine patch, Nicotine lozenge
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2024 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

NCT05271578
View directory record Official record
Conditions
Vascular Reactivity, Serum Biomarkers
Interventions
Standardized Electronic Research Cigarette, Nicotine Research Cigarette
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Acute Effects of E-Cigarette Aerosol Inhalation

NCT03479203
View directory record Official record
Conditions
Endothelial Dysfunction, Biochemical Markers
Interventions
Electronic Cigarette Aerosol
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 35 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

NCT05294497
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product N, Product E
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Lexington, Kentucky • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Online Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults

NCT06129123
View directory record Official record
Conditions
E-cigarette Use
Interventions
Live Free From E-cigarettes
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 24 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 1

NCT05958979
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
Interventions
Control Marketing Strategies, Experimental Marketing Strategies
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
601 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2023 · Synced Oct 20, 2026, 7:02 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Electronic Cigarettes on Lung Biology

NCT02188511
View directory record Official record
Conditions
Lung Disease, Lung Disorder
Interventions
Group A, Group B, Group C, Group D, Group E
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
21 Years to 85 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2020 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Virtual Reality Game to Prevent E-cigarette and Cannabis Vaping

NCT07413432
View directory record Official record
Conditions
Cannabis, Vaping, Emotion Regulation
Interventions
Virtual reality videogame intervention for vaping prevention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants

NCT05114863
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
Product A1, Product B, Product C, Product D, Product A2, Product E, Product F, Product G, Product H, Product N
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

NCT05881304
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Standardized research e-cigarette (SREC)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Active, not recruiting Not applicable Interventional

Electronic Cigarettes and Reactivity to Smoking Cues

NCT01782599
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Dual nicotine patch and electronic cigarette
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Assess Tobacco-related Biomarkers of Exposure in Smokers Using myBlu E-cigarettes

NCT04019626
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Continue-smoking, myblu Tobacco 2.5%, myblu Tobacco 4.0%, myblu Honeymoon 2.5%, myblu Honeymoon 4.0%, JUUL 5%
Other
Lead sponsor
Fontem Ventures BV
Industry
Eligibility
21 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 20, 2026, 7:02 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Alternate Nicotine Delivery Systems and Airway Epithelial Biology

NCT01974063
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190501: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting

NCT04226404
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
CSD1905-11, CSD1905-12, CSD1905-13, CSD1905-14, CSD1905-15, CSD1905-16, CSD1905-17
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neuroimaging Approaches to Improve Prediction of Smoking Initiation and Nicotine Escalation in Young Adult ENDS Users

NCT05447325
View directory record Official record
Conditions
Message Exposure (Sequence: Regular Then Flavor), Message Exposure (Sequence: Flavor Then Regular), No Message Exposure (Control Condition)
Interventions
Exposure to Anti-Vaping Messages (generic themes then flavor-specific themes), Exposure to Anti-Vaping Messages (flavor-specific themes then generic themes), Exposure to Anti-Vaping Messages (no message exposure)
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years to 29 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Uptake and Abuse Liability Assessments of Blu Disposable Electronic Cigarettes

NCT05457634
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Combustible Cigarette, blu Disposable A, blu Disposable B, blu Disposable C, blu Disposable D, blu Disposable E
Other
Lead sponsor
Fontem US LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 20, 2026, 7:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190301: A Study to Assess Elements of Abuse Liability for Two Dissolvable Nicotine Lozenge Tobacco Products

NCT04167384
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product E, Product F, Product G, Product H
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 20, 2026, 7:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NCT06372899
View directory record Official record
Conditions
E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions
E-cigarettes, Oral nicotine pouches
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 20, 2026, 7:02 AM EDT
Recruiting Phase 2 Interventional

The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

NCT07322432
View directory record Official record
Conditions
Addiction Nicotine
Interventions
VapeAway filter system
Device
Lead sponsor
VapeAway
Industry
Eligibility
21 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 20, 2026, 7:02 AM EDT