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ClinicalTrials.gov public records Last synced Oct 30, 2026, 7:17 PM EDT

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Showing 241–264 of 439 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: e-cigarettes Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Vaping THC From Electronic Cigarettes

NCT02955329
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Nicotine, Cannabis, PAX Loose Leaf Vaporizer
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2023 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Phase 2 Interventional Results available

The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products

NCT03492463
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
Nicotine patch, Placebo patch, E-cigarettes, Non-nicotine e-cigarettes
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Results available

E-cigarettes for Harm Reduction in Adults With Asthma

NCT05278065
View directory record Official record
Conditions
Smoking, Asthma, Electronic Cigarette Use, Cigarette Smoking
Interventions
Nicotine
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoking Cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes

NCT02416011
View directory record Official record
Conditions
Smoking Cessation
Interventions
GENERIC, eTARGET
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,896 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 23, 2022 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190301: A Study to Assess Elements of Abuse Liability for Two Dissolvable Nicotine Lozenge Tobacco Products

NCT04167384
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product E, Product F, Product G, Product H
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reactions to E-cigs and Alcohol

NCT03449017
View directory record Official record
Conditions
Alcohol Abuse, Nicotine Dependence Tobacco Product
Interventions
E-cig use
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Oct 30, 2026, 7:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-Cigarette Perception

NCT07398976
View directory record Official record
Conditions
Nicotine Dependence, E-cigarette Use
Interventions
Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml)
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Moment Study: Mixed Method E-cigarette Study

NCT02261363
View directory record Official record
Conditions
Smoking
Interventions
Ecig group 1
Other
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 30, 2026, 7:17 PM EDT
Terminated Phase 4 Interventional Results available

e-Cigarettes Versus NRT Gum for Smoking Cessation

NCT01925781
View directory record Official record
Conditions
Nicotine Addiction, Smoking Cessation
Interventions
Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer
Drug · Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Phase 3 Interventional

Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers

NCT06435221
View directory record Official record
Conditions
Smoking Cessation, Vaping Cessation
Interventions
Cytisinicline
Drug
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
29
States / cities
Mobile, Alabama • Tempe, Arizona • Little Rock, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Phase 2 Interventional

Internet-Based Nonsmoking Program for Postpartum Women

NCT02602730
View directory record Official record
Conditions
Cigarette Smoking, Smoking, Tobacco
Interventions
Break the Chain, Clearing the Air
Behavioral
Lead sponsor
Oregon Center for Applied Science, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
307 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190203: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting

NCT04104152
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
CSD1902-11, CSD1902-12, CSD1902-13, CSD1902-14, CSD1902-21, CSD1902-22, CSD1902-23, CSD1902-24
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
146 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The MARY-JANE Cannabis and Heart Rhythm Trial

NCT06021613
View directory record Official record
Conditions
Premature Atrial Contractions, Premature Ventricular Contractions
Interventions
Randomized instructions
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 30, 2026, 7:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vape-Free Text-Messaging: Pilot Study

NCT05906082
View directory record Official record
Conditions
E-cigarette Use
Interventions
E-cigarette cessation text-messaging intervention, Standard care control using standard national resources
Behavioral
Lead sponsor
Jovan Gwon, PhD, RN, FIAAN
Other
Eligibility
18 Years to 24 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Oct 30, 2026, 7:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

NCT06264154
View directory record Official record
Conditions
Smoking, Tobacco Use, Cigarette Smoking, E-Cig Use
Interventions
E-cigarettes
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes

NCT03905928
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor, Placebo ECIG with Tobacco Flavor, Placebo ECIG with Strawberry Vanilla Flavor
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 30, 2026, 7:17 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Factors That Impact the Relationship Between Pulmonary Status and Susceptibility to Electronic Cigarette Use

NCT04151784
View directory record Official record
Conditions
Electronic Cigarette Use, Pulmonary Disease
Interventions
Pulmonary Group, Healthy Control
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use

NCT04084210
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch, Placebo Patch
Device · Other · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Graphic Messages to Prevent E-Cigarette Use Among Black and Latino Adolescents

NCT04899999
View directory record Official record
Conditions
Vaping
Interventions
Financial reward graphic message, Health reward graphic message, Self-efficacy graphic message, Social norms graphic message
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
12 Years to 17 Years
Enrollment
362 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Middle School Cluster Randomized Controlled Trial (RCT) to Evaluate E-Cigarette Prevention Program: CATCH My Breath

NCT04843501
View directory record Official record
Conditions
E-cigarette Use
Interventions
CATCH My Breath (CMB) program for E-cigarette prevention among adolescents, Texas Education Agency (TEA) required tobacco prevention program
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
10 Years to 15 Years
Enrollment
2,059 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Vascular Effects of a Single Bout of Electronic Cigarette Use

NCT03209661
View directory record Official record
Conditions
Arterial Stiffness
Interventions
E-cigarette, Nicotine 0%, Menthol Inhalant Product
Drug
Lead sponsor
University of Texas at Austin
Other
Eligibility
20 Years to 30 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 30, 2026, 7:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vaping and Smoking Withdrawal Project

NCT05772845
View directory record Official record
Conditions
Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions
Acute (24-hour) abstinence, Ad libitum smoking/vaping
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
21 Years to 50 Years
Enrollment
370 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes With Nicotine Salt Formulations

NCT03822546
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Conventional cigarette, myblu 25 mg freebase, myblu 16 mg nicotine salt, myblu 25 mg nicotine salt, myblu 40 mg nicotine salt, blu PRO 48 mg nicotine salt
Other
Lead sponsor
Fontem Ventures BV
Industry
Eligibility
25 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 30, 2019 · Synced Oct 30, 2026, 7:17 PM EDT
Completed Not applicable Interventional Results available

Trial on the Effect of E-cigarette Advertising on Cigarette Perceptions in Adolescents

NCT03786042
View directory record Official record
Conditions
Attentional Bias, Smoking Cues, Positive Perceptions About Cigarette Smoking, Social Norms, Smoking Susceptibility
Interventions
E-cigarette ad exposure, non e-cigarette TV commercials
Behavioral · Other
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
14 Years to 17 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 30, 2026, 7:17 PM EDT