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ClinicalTrials.gov public records Last synced Oct 30, 2026, 5:47 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 439 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: e-cigarettes Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Menthol on ENDS Users' Addiction and Exposure

NCT05338801
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette
Other
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 35 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 30, 2026, 5:47 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)

NCT03750825
View directory record Official record
Conditions
Cigarette Smoking
Interventions
NIDA Standard Research E-cigarette (SREC)
Device
Lead sponsor
University of Southern California
Other
Eligibility
22 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 30, 2026, 5:47 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Smoking Cessation Via Telehealth Options in Primary Care

NCT05493254
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smoking cessation e-visit, Treatment As Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 30, 2026, 5:47 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impact of E-cigarette Use on the Body

NCT04972513
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Nitric Oxide Breath Test, Oscillometry, Spirometry, Survey Administration, Endothelial function
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
15 Years to 25 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD170303: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes

NCT03234010
View directory record Official record
Conditions
Smoking
Interventions
FT21092, FT21093, FT21096, FT21097
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 20, 2017 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Phase 2 Interventional Results available

Varenicline for Treatment of E-cigarette Dependence

NCT05541497
View directory record Official record
Conditions
Smoking Cessation
Interventions
Varenicline Tartrate, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
New Haven, Connecticut • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Oct 30, 2026, 5:47 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Guiding Good Choices for Health

NCT04040153
View directory record Official record
Conditions
Adolescent Substance Use
Interventions
Guiding Good Choices
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 12 Years
Enrollment
3,636 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
3
States / cities
Oakland, California • Aurora, Colorado • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Clinical Trial to Reduce Harm From Tobacco

NCT02328794
View directory record Official record
Conditions
Smoking Cessation
Interventions
E-cigarette free access, E-cigarette/NRT/Zyban/Chantix Choice, Outcome Incentive arm, Loss framing incentive arm, Control
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
6,006 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Oct 30, 2026, 5:47 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

NCT03943706
View directory record Official record
Conditions
Tobacco Use
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 19, 2020 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Neuroimaging Approach to Advance Mechanistic Understanding of Tobacco Use Escalation Risk Among Young Adult African American Vapers

NCT05829863
View directory record Official record
Conditions
Message Exposure
Interventions
educational message exposure
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years to 29 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Oct 30, 2026, 5:47 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

NCT06922617
View directory record Official record
Conditions
Tobacco Use, Substance Use Disorders
Interventions
Switching to E-Cigarette, Quitting using Medication, Counseling
Behavioral · Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
4
States / cities
Charleston, South Carolina • Conway, South Carolina • Greenville, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 30, 2026, 5:47 PM EDT
Enrolling by invitation No phase listed Observational

Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids

NCT06619964
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Not listed
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 30, 2026, 5:47 PM EDT
Withdrawn Not applicable Interventional

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

NCT04258852
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Low strength nicotine e-liquid, High strength nicotine e-liquid
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 16, 2024 · Synced Oct 30, 2026, 5:47 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

NCT02585791
View directory record Official record
Conditions
Healthy Lifetime Non-smokers
Interventions
Propylene Glycol, vegetable glycerin, PG+VG
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

NCT05294497
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product N, Product E
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Lexington, Kentucky • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Biomarkers of Tobacco Exposure, Urge-to-Smoke Following Exclusive and Dual Ad Lib Use of Electronic Cigarettes

NCT02385227
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Exclusive blu™ e-cigarette A1, Exclusive blu™ e-cigarette A2, Exclusive blu™ e-cigarette A3, Dual blu™ e-cigarette and usual brand B1, Dual blu™ e-cigarette and usual brand B2, Dual blu™ e-cigarette and usual brand B3, Nicotine product cessation C
Other
Lead sponsor
Lorillard Tobacco Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 11, 2015 · Synced Oct 30, 2026, 5:47 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use

NCT03491059
View directory record Official record
Conditions
E-cigarette Use
Interventions
C-11 labeled nicotine, PET/CT imaging
Drug · Radiation
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 80 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Two New Electronic Cigarettes in Cigarette Smokers

NCT03435562
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 3, 2020 · Synced Oct 30, 2026, 5:47 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

To Vape or Not to Vape

NCT05240027
View directory record Official record
Conditions
Vaping
Interventions
Vape use survey
Behavioral
Lead sponsor
Methodist Health System
Other
Eligibility
12 Years and older
Enrollment
363 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Results available

Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

NCT05110872
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cigarette flavor restricted and e-cigarette flavor restricted, Cigarette flavor restricted and e-cigarette flavor unrestricted, Cigarette flavor unrestricted and e-cigarette flavor restricted, Cigarette flavor unrestricted and e-cigarette flavor unrestricted
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Characterize Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouches in Adult Cigarette Smokers

NCT04846088
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product E, Product F, Product G, Product H, Product I
Other
Lead sponsor
British American Tobacco (Investments) Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2022 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Responses to E-Cigarette Advertising

NCT04249219
View directory record Official record
Conditions
E-Cig Use
Interventions
Viewing e-cigarette ads
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 26 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2023 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Early Phase 1 Interventional Results available

Effects of Flavors on Nicotine Reinforcement in Smokers

NCT03243630
View directory record Official record
Conditions
Nicotine Dependence
Interventions
IV nicotine, Menthol flavor, green apple, green apple and menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Oct 30, 2026, 5:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Implementation and Dissemination of an Evidence-Based Tobacco Product Use Prevention Videogame Intervention With Adolescents

NCT03815591
View directory record Official record
Conditions
Smoking Cessation, Smoking
Interventions
smokeSCREEN web-based game
Device
Lead sponsor
Yale University
Other
Eligibility
10 Years to 16 Years
Enrollment
560 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 22, 2022 · Synced Oct 30, 2026, 5:47 PM EDT