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Showing 1–24 of 52 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: endomicroscopy Clear all
Completed No phase listed Observational

Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract

NCT01770405
View directory record Official record
Conditions
Pancreatic Cyst, Pancreatic Neoplasms, Pancreatic Adenoma, Pancreatic Cancer, Pancreatic Islet Cell Tumors, Lymph Node Mass, Lymphadenopathy, GIST
Interventions
Endoscopic ultrasound fine needle aspiration
Device
Lead sponsor
Mauna Kea Technologies
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
4
States / cities
Atlanta, Georgia • Manhasset, New York • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2017 · Synced Sep 6, 2026, 8:06 AM EDT
Completed No phase listed Observational

Registry Trial to Determine pCLE Image Interpretation Criteria and Preliminary Accuracy in the Lung

NCT01793246
View directory record Official record
Conditions
Lung Neoplasms, Disorder Related to Lung Transplantation
Interventions
probe based laser endomicroscopy (pCLE)
Device
Lead sponsor
Mauna Kea Technologies
Industry
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
9
States / cities
Phoenix, Arizona • Jacksonville, Florida • Chicago, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2017 · Synced Sep 6, 2026, 8:06 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy

NCT07546617
View directory record Official record
Conditions
Endonasal Surgery, Endoscopic Sinus Surgery, Olfactory Dysfunction
Interventions
CONVIVO system, Fluorescein injection, USP 10%
Device · Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 6, 2026, 8:06 AM EDT
Terminated Not applicable Interventional Results available

Staging of Superficial EAC Using VLE

NCT03385343
View directory record Official record
Conditions
Esophageal Cancer
Interventions
VLE imaging for staging EAC
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 95 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Sep 6, 2026, 8:06 AM EDT
Completed No phase listed Observational

Characterization of the Neo-squamous Epithelial Barrier

NCT03077594
View directory record Official record
Conditions
Barrett's Esophagus With Dysplasia
Interventions
Mucosal Impedance, Research Biopsies, Volumetric Laser Endomicroscopy
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
2
States / cities
Rochester, Minnesota • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 17, 2023 · Synced Sep 6, 2026, 8:06 AM EDT
Enrolling by invitation No phase listed Observational

Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease

NCT04566341
View directory record Official record
Conditions
Parkinson Disease, Parkinson
Interventions
OCT - TCE
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Sep 6, 2026, 8:06 AM EDT
Withdrawn Not applicable Interventional

Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD)

NCT02039869
View directory record Official record
Conditions
Gastroesophageal Reflux Disease, Non Erosive Reflux Disease, Dyspepsia
Interventions
Confocal endomicroscopy, Proton pump inhibitor, Sucralfate
Device · Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 79 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
3
States / cities
Kenner, Louisiana • Charleston, South Carolina • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2015 · Synced Sep 6, 2026, 8:06 AM EDT
Terminated Not applicable Interventional Results available

Needle-Based Confocal Laser Endomicroscopy for Diagnosis of Lung Cancer in Patients With Peripheral Pulmonary Nodules

NCT05556525
View directory record Official record
Conditions
Lung Carcinoma
Interventions
Fluorescein, Image-Guided Needle Confocal Laser Endomicroscopy, Ultrasound-Guided Transbronchial Needle Aspiration
Other · Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 6, 2026, 8:06 AM EDT
Completed Not applicable Interventional

Healing of the Esophageal Mucosa After RFA of Barrett's Esophagus

NCT02688114
View directory record Official record
Conditions
Barrett Esophagus
Interventions
Baseline surveillance endoscopy, Radiofrequency ablation, Follow up endoscopy 1, Follow up endoscopy 2, Follow up endoscopy 3
Procedure
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2023 · Synced Sep 6, 2026, 8:06 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Imaging of the Esophagus Using a SECM Capsule

NCT03546660
View directory record Official record
Conditions
Eosinophilic Esophagitis, Barrett Esophagus
Interventions
SECM capsule
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Sep 6, 2026, 8:06 AM EDT
Not listed Not applicable Interventional

Prospective Study for Evaluating Colon Polyp Histology With in Vivo Probe Based Confocal Laser Endomicroscopy

NCT01214031
View directory record Official record
Conditions
Colon Polyps, Adenomatous Polyps, Colon Cancer
Interventions
Confocal laser endomicroscopy (CLE)
Device
Lead sponsor
Midwest Biomedical Research
Other
Eligibility
18 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 8, 2012 · Synced Sep 6, 2026, 8:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Study for Imaging of the Esophagus Using a Tethered Capsule OCT Endomicroscopy in the Primary Care Setting

NCT02445027
View directory record Official record
Conditions
Healthy
Interventions
MGH OCT Imaging Capsule
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 16, 2023 · Synced Sep 6, 2026, 8:06 AM EDT
Completed No phase listed Observational

A Registry of Patients Undergoing Cellvizio Endomicroscopy and Endoscopic Retrograde Cholangiopancreatography(ERCP) Imaging Procedures for Diagnosing Pancreatic and Bile Duct Cancers

NCT00779688
View directory record Official record
Conditions
Pancreatic Cancer, Bile Duct Cancer
Interventions
Probe-based confocal laser endomicroscopy
Device
Lead sponsor
Mauna Kea Technologies
Industry
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
4
States / cities
Aurora, Colorado • Boston, Massachusetts • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2011 · Synced Sep 6, 2026, 8:06 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)

NCT03228407
View directory record Official record
Conditions
Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
Interventions
Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
Procedure · Diagnostic Test
Lead sponsor
McGuire Research Institute
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Sep 6, 2026, 8:06 AM EDT
Terminated Phase 4 Interventional

A Trial Comparing Yield of Confocal Endomicroscopy Guided Biopsies

NCT01030263
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
Fluorescence-aided confocal endomicroscopy guided biopsy., Random four-quadrant biopsies.
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 24, 2010 · Synced Sep 6, 2026, 8:06 AM EDT
Completed Not applicable Interventional

Confocal Endomicroscopy of Pancreatic InVivo

NCT01035008
View directory record Official record
Conditions
Pancreatic Cysts
Interventions
Endoscopic Ultrasound (EUS)
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 22, 2012 · Synced Sep 6, 2026, 8:06 AM EDT
Completed Not applicable Interventional Results available

CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia

NCT01032044
View directory record Official record
Conditions
Barrett Syndrome, Barrett's Syndrome, Barrett's Esophagus, Barrett Esophagus, Adenocarcinoma
Interventions
Standard endoscopic evaluation, pCLE guided evaluation
Device
Lead sponsor
Mauna Kea Technologies
Industry
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
4
States / cities
Jacksonville, Florida • Chicago, Illinois • Kansas City, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2016 · Synced Sep 6, 2026, 8:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

CONVIVO Endomicroscopy

NCT06087393
View directory record Official record
Conditions
Brain Tumor
Interventions
CONVIVO
Device
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 6, 2026, 8:06 AM EDT
Recruiting Not applicable Interventional

Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

NCT03830801
View directory record Official record
Conditions
Barrett Esophagus
Interventions
IVLCM tethered capsule
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Sep 6, 2026, 8:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Confocal Endomicroscopy for GI Neoplasia Study

NCT01515514
View directory record Official record
Conditions
Colorectal Polyps
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 16, 2013 · Synced Sep 6, 2026, 8:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Pilot Study for Imaging of the Esophagus Using Tethered Capsule OCT Endomicroscopy With Distal Scanning

NCT02947997
View directory record Official record
Conditions
Healthy
Interventions
OFDI capsule
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 16, 2023 · Synced Sep 6, 2026, 8:06 AM EDT
Completed Not applicable Interventional Results available

Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS)

NCT03814824
View directory record Official record
Conditions
Barrett's Esophagus Without Dysplasia, Barrett's Esophagus With Dysplasia, Barrett's Esophagus With Low Grade Dysplasia, Barrett's Esophagus With High Grade Dysplasia, Barrett's Esophagus With Dysplasia, Unspecified
Interventions
IRIS (Intelligent real-time image segmentation), VLE (Volumetric laser endomicroscopy)
Diagnostic Test
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
3
States / cities
Scottsdale, Arizona • Rochester, Minnesota • Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Sep 6, 2026, 8:06 AM EDT
Active, not recruiting No phase listed Observational

Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy

NCT02994693
View directory record Official record
Conditions
Barrett Esophagus, Barretts Esophagus With Dysplasia
Interventions
OFDI capsule imaging
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Sep 6, 2026, 8:06 AM EDT
Completed No phase listed Observational

High Resolution Optical Imaging of Barrett's Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE)

NCT01503411
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
Not listed
Lead sponsor
NinePoint Medical
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
3
States / cities
Jacksonville, Florida • Rochester, Massachusetts • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 8, 2014 · Synced Sep 6, 2026, 8:06 AM EDT