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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: esophageal manometry Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

External Pharyngeal Exerciser and Pharyngeal Phase of Swallowing

NCT05708911
View directory record Official record
Conditions
Dysphagia
Interventions
Pharyngeal exerciser
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

High Resolution Pharyngeal Manometry (HRPM) Biofeedback

NCT07508059
View directory record Official record
Conditions
Healthy
Interventions
Swallowing Maneuvers, High Resolution Pharyngeal Manometry (HRPM)
Other · Diagnostic Test
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 40 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry

NCT06329583
View directory record Official record
Conditions
Gastroesophageal Reflux, Dysphagia, Esophageal Motility Disorders
Interventions
diaphragmatic breathing
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Terminated No phase listed Observational

Establishing a Correlation Between HRM and UGI MM Studies

NCT06314893
View directory record Official record
Conditions
Esophageal Motility Disorders
Interventions
Not listed
Lead sponsor
Lexington Health Incorporated
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
West Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Sep 3, 2026, 5:02 AM EDT
Terminated No phase listed Observational Results available

Esophageal Pressure Measurements During One-lung Ventilation

NCT04725318
View directory record Official record
Conditions
Surgery, One-lung Ventilation
Interventions
One-lung ventilation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Completed No phase listed Observational

Upper GI MM vs Manometry

NCT06973070
View directory record Official record
Conditions
GERD (Gastroesophageal Reflux Disease)
Interventions
Not listed
Lead sponsor
Lexington Health Incorporated
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
West Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 3, 2026, 5:02 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effects of an Air Bolus on Primary Peristalsis

NCT06465355
View directory record Official record
Conditions
Deglutition Disorders
Interventions
pharyngo-esophageal high-resolution manometry
Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
21 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Sep 3, 2026, 5:02 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Sparkle Respiratory Effort Validation

NCT04630639
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Sleep Apnea, Central
Interventions
Sparkle
Device
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Sep 3, 2026, 5:02 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

High Resolution Manometry for Swallowing

NCT01773330
View directory record Official record
Conditions
Motility Disorder
Interventions
esophageal manometry, Gatorade, Supine position, Semi-recumbent position, Sitting, Standing
Procedure · Dietary Supplement · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Sep 3, 2026, 5:02 AM EDT
Completed Not applicable Interventional

Per-Oral Endoscopic Esophagomyotomy (POEM)

NCT01635374
View directory record Official record
Conditions
Achalasia
Interventions
Per-Oral Endoscopic Esophagomyotomy
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 85 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 5, 2015 · Synced Sep 3, 2026, 5:02 AM EDT
Withdrawn Not applicable Interventional

HRIM vs Mucosal Impedance in GERD Participants

NCT02812407
View directory record Official record
Conditions
Gastro-esophageal Reflux Disease (GERD)
Interventions
Mucosal Impedance
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 8, 2020 · Synced Sep 3, 2026, 5:02 AM EDT
Completed Not applicable Interventional Results available

Real-time Effort Driven VENTilator Management

NCT03266016
View directory record Official record
Conditions
Ventilation Therapy; Complications, Diaphragm Disease, Pediatric Respiratory Diseases
Interventions
Computerized Ventilator Protocol, Esophageal Manometry, Respiratory Inductance Plethysmography (RIP), Diaphragm Ultrasound, Maximal Inspiratory Pressure
Other · Diagnostic Test
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
30 Days to 18 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 3, 2026, 5:02 AM EDT
Completed Not applicable Interventional

The Role That Peroral Endoscopic Myotomy (POEM) Could Play in the Treatment of Achalasia

NCT01584635
View directory record Official record
Conditions
Achalasia
Interventions
Peroral Endoscopic Myotomy a less invasive treatment for Achalasia
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 30, 2016 · Synced Sep 3, 2026, 5:02 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mechanisms Preventing Pharyngeal Reflux

NCT05696184
View directory record Official record
Conditions
GERD
Interventions
Concurrent manometry/impedance/pH with video pharyngo-laryngoscopy, Slow and rapid intra-esophageal infusion
Diagnostic Test
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Recruiting Phase 3 Interventional

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

NCT06066502
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Respiratory Failure
Interventions
Precision ventilation, Guided usual care ventilation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
33
States / cities
Tucson, Arizona • Little Rock, Arkansas • La Jolla, California + 25 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Terminated No phase listed Observational

Pilot Study: Utilizing Manometry to Assess Radiation-Induced Changes in Esophageal Function

NCT01992068
View directory record Official record
Conditions
Lung Cancer
Interventions
Not listed
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years to 99 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2017 · Synced Sep 3, 2026, 5:02 AM EDT
Completed Not applicable Interventional Results available

Esophageal Manometry During Recovery From Anesthesia: Pilot Study

NCT02661386
View directory record Official record
Conditions
Motility Function
Interventions
Motility Procedure
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Rehabilitation Manometry Study

NCT04130867
View directory record Official record
Conditions
Oropharyngeal Dysphagia
Interventions
pHRM, VFSS
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 3, 2026, 5:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Dx-pH Probe in Diagnosing Extra-esophageal Reflux Disease

NCT00388453
View directory record Official record
Conditions
GERD, Larynx Disease
Interventions
Dx-pH Probe, Manometry
Device · Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 26, 2017 · Synced Sep 3, 2026, 5:02 AM EDT
Enrolling by invitation Not applicable Interventional

Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO

NCT07141524
View directory record Official record
Conditions
VA-ECMO
Interventions
Physiology measurements
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 3, 2026, 5:02 AM EDT
Withdrawn Not applicable Interventional

Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM)

NCT02428959
View directory record Official record
Conditions
Dysphagia, Achalasia
Interventions
Amyl Nitrite
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 29, 2019 · Synced Sep 3, 2026, 5:02 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Atrial Fibrillation Ablation on Gastric Motility "The AF Gut Study"

NCT01396356
View directory record Official record
Conditions
Atrial Fibrillation Ablation Procedure
Interventions
GI procedures
Procedure
Lead sponsor
Dhanunjaya Lakkireddy, MD, FACC
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2013 · Synced Sep 3, 2026, 5:02 AM EDT
Withdrawn No phase listed Observational

Transoral Incisionless Fundoplication (TIF) for Laryngopharyngeal Reflux (LPR) Patients

NCT05579587
View directory record Official record
Conditions
Gastroesophageal Reflux Disease (GERD), Laryngopharyngeal Reflux (LPR), Reflux Disease, Gastro-Esophageal, Motility Disorder
Interventions
Transoral Incisionless Fundoplication
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Sep 3, 2026, 5:02 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Non-invasive Markers of Esophageal Function in Adults

NCT04074356
View directory record Official record
Conditions
Dysphagia
Interventions
Clinical measure questionnaires, EESG, MESG, High resolution manometry (HRM)
Other · Diagnostic Test
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 3, 2026, 5:02 AM EDT