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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: foot orthotics Clear all
Terminated Not applicable Interventional Results available

Effect of Lower Extremity Ankle Foot Orthoses in Parkinson's Disease

NCT01798927
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Ankle foot orthosis
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
50 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 2, 2015 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Results available

Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke.

NCT02693834
View directory record Official record
Conditions
Stroke, CVA, Hemiplegia, Hemiparesis, Foot Drop
Interventions
Posterior Leaf spring AFO, Double adjustable AFO
Device
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Sep 25, 2026, 10:54 PM EDT
Recruiting Not applicable Interventional

The Effects of AFO Heel Height and Stiffness on Gait

NCT04800484
View directory record Official record
Conditions
Musculoskeletal Injury, Musculoskeletal Diseases, Peripheral Nervous System Diseases
Interventions
Tall Soft, Tall Firm, Short Soft, Short Firm
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 25, 2026, 10:54 PM EDT
Recruiting Not applicable Interventional

Nomad P-KAFO Study

NCT05644522
View directory record Official record
Conditions
Cerebrovascular Accident, Post-polio Syndrome, Spinal Cord Injuries, Multiple Sclerosis, Muscular Dystrophy, Paralysis
Interventions
Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 25, 2026, 10:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reliability of Force Measurement Within the Carbon Fiber Orthosis Proximal Cuff

NCT06127264
View directory record Official record
Conditions
Healthy, Ankle Foot Orthosis (AFO), Peripheral Neuropathy
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 25, 2026, 10:54 PM EDT
Recruiting Not applicable Interventional

Impact of Foot Orthoses on Gait in Individuals With Ataxia

NCT07720700
View directory record Official record
Conditions
Ataxia
Interventions
Home wearing schedule
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Phase 4 Interventional Results available

Mobility Training Using a Bionic Knee Orthosis in Patients Chronic Post-Stroke: A Case Series

NCT01499862
View directory record Official record
Conditions
Stroke
Interventions
Tibion Bionic Leg
Device
Lead sponsor
Tibion Bionics, Inc.
Industry
Eligibility
40 Years to 60 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Sep 25, 2026, 10:54 PM EDT
Terminated Not applicable Interventional Results available

Effectiveness of Ankle Foot Orthoses on Gait in Multiple Sclerosis

NCT01796860
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
AFO
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2015 · Synced Sep 25, 2026, 10:54 PM EDT
Recruiting Phase 2 Interventional

Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy

NCT07434492
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Smart Ankle-Foot Orthosis, 5-Azacitidine, Placebo
Device · Drug
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
8 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Biomechanical Analysis of CAM Boot and EVENUp Lift

NCT05365594
View directory record Official record
Conditions
Biomechanics, Limb Length Discrepancy
Interventions
Controlled Ankle Movement Boot, EVENUp Lift
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 24, 2024 · Synced Sep 25, 2026, 10:54 PM EDT
Withdrawn Not applicable Interventional

Investigating the Effects of Sensory Input Orthotics in Disorders of Posture and Movement

NCT04091594
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Flexible orthotic, Standard orthotic
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
6 Months to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 7, 2020 · Synced Sep 25, 2026, 10:54 PM EDT
Not yet recruiting Not applicable Interventional

Effects of Powered Hip Flexion Device in Persons With Multiple Sclerosis

NCT07724093
View directory record Official record
Conditions
Multiple Sclerosis (MS) Relapsing Remitting
Interventions
Powered Hip Flexion Orthosis (Hypershell X)
Device
Lead sponsor
University of Dayton
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 25, 2026, 10:54 PM EDT
Recruiting Not applicable Interventional

Effect of Custom Dynamic Orthoses on Forefoot Loading

NCT06710119
View directory record Official record
Conditions
Lower Extremity Injuries
Interventions
Visual Feedback
Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Iowa City, Iowa • Everett, Washington
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Custom Molded Foot Orthoses Effect on Foot Kinematics and Lower Extremity Electromyography During Walking and Running.

NCT02143947
View directory record Official record
Conditions
Lower Extremity Pain of a Mechanical Origin
Interventions
Maximal Arch Subtalar Stabilization, Full Contact Orthosis
Device
Lead sponsor
Quinnipiac University
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Hamden, Connecticut
Source: ClinicalTrials.gov public record
Updated May 17, 2015 · Synced Sep 25, 2026, 10:54 PM EDT
Recruiting Not applicable Interventional

Characterization and Clinical Trial of a Variable Friction Shoe

NCT06234124
View directory record Official record
Conditions
Stroke
Interventions
Variable Friction Shoe Training, Ankle Foot Orthosis (AFO) Training
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Results available

Ankle Foot Orthosis Comparative Effect

NCT03901053
View directory record Official record
Conditions
Foot Injuries and Disorders
Interventions
Reaktiv AFO, PhatBrace AFO
Device
Lead sponsor
Jason Wilken
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
3
States / cities
Iowa City, Iowa • Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Results available

Ankle-foot Orthoses for Peripheral Artery Disease

NCT02280200
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
AFO to improve outcomes
Device
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patients

NCT03524729
View directory record Official record
Conditions
Ankle Osteoarthritis, Healthy Ankles
Interventions
Rocker bottom shoe, Ankle foot orthosis, Standard walking shoe
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 25, 2026, 10:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Investigating Auto Adjusting Dynamic AFO

NCT04623853
View directory record Official record
Conditions
Lower Limb; Fusion, Congenital, Lower Limb Fracture, Ankle Foot Injury
Interventions
Variable Stiffness AFO
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Sep 25, 2026, 10:54 PM EDT
Not listed Phase 2 Interventional

A Novel Approach to Plantar Fasciitis in the Aging Population

NCT05834491
View directory record Official record
Conditions
Plantar Fasciitis, Chronic
Interventions
minimal shoes and foot strengthening and flexibility exercises, Supportive Footwear, foot orthotic device and foot flexibility exercises
Device
Lead sponsor
University of South Florida
Other
Eligibility
50 Years to 70 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Results available

A Trial of Custom Foot Orthoses for the Treatment of Plantar Heel Pain

NCT00765843
View directory record Official record
Conditions
Plantar Fasciitis
Interventions
orthoses
Device
Lead sponsor
Rosalind Franklin University of Medicine and Science
Other
Eligibility
18 Years to 75 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Chicago, Illinois • North Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 20, 2014 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Results available

Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop

NCT01138995
View directory record Official record
Conditions
Sensorimotor Gait Disorder, Neurologic Ambulation Disorder, Gait, Drop Foot, Poststroke Hemiparesis, Post-Cerebrovascular Accident (CVA) Hemiparesis
Interventions
Ness L300, Ankle-foot orthosis
Device
Lead sponsor
Bioness Inc
Industry
Eligibility
18 Years and older
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
11
States / cities
Downey, California • Long Beach, California • San Diego, California + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2016 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Phase 2 Interventional Results available

Bracing and Strengthening for Posterior Tibial Tendon Dysfunction

NCT00756457
View directory record Official record
Conditions
Posterior Tibial Tendon Dysfunction
Interventions
Bracing, Strengthening exercises, Stretching exercises
Device · Other
Lead sponsor
Ithaca College
Other
Eligibility
40 Years to 80 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2014 · Synced Sep 25, 2026, 10:54 PM EDT
Completed Not applicable Interventional Results available

Cerebral Palsy Early Mobility Training

NCT02340026
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Dynamic Supported Mobility, Conventional Therapy
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
12 Months to 36 Months
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Sep 25, 2026, 10:54 PM EDT