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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: fructose Clear all
Terminated Not applicable Interventional Results available

Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine

NCT02169830
View directory record Official record
Conditions
Migraine Disorders
Interventions
nortriptyline, Topiramate, Diet Modification
Drug · Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adverse Metabolic Effects of Dietary Sugar

NCT02548767
View directory record Official record
Conditions
Chronic Disease of Cardiovascular System, Type 2 Diabetes, Obesity
Interventions
high fructose corn syrup, aspartame, Energy-balanced diet, Ad libitum diet
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 40 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
3
States / cities
Davis, California • Sacramento, California • Vallejo, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Sep 12, 2026, 4:35 AM EDT
Terminated Phase 4 Interventional Results available

Topiramate Treatment of Alcohol Use Disorders in African Americans

NCT03018704
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Topiramate, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Decatur, Georgia • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 12, 2026, 4:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

NCT04623502
View directory record Official record
Conditions
Kidney Cancer, Renal Cell Carcinoma, Clear Cell Carcinoma, Urothelial Carcinoma, Metastatic Kidney Cancer, Metastatic Urothelial Carcinoma, Papillary Renal Cell Carcinoma, Chromophobe Renal Cell Carcinoma, Fumarate Hydratase Deficiency, Succinate Dehydrogenase-Deficient Renal Cell Carcinoma, HLRCC, Hereditary Leiomyomatosis and Renal Cell Cancer
Interventions
13C-Glucose, 13C-Acetate, 13C-Lactate, 13C-Glutamine, 13C-Fructose
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Early Phase 1 Interventional Results available

Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose

NCT03469492
View directory record Official record
Conditions
Hyperglycaemia (Diabetic)
Interventions
Insulin, exercise, Dietary counseling
Drug · Behavioral · Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 4, 2024 · Synced Sep 12, 2026, 4:35 AM EDT
Withdrawn Not applicable Interventional

Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine

NCT00777218
View directory record Official record
Conditions
Migraine
Interventions
propranolol, zonisamide, topiramate
Drug
Lead sponsor
University of South Alabama
Other
Eligibility
8 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Fructose-Induced Palmitate Synthesis in Overweight Subjects

NCT00535535
View directory record Official record
Conditions
Elevated Triglycerides, Diabetes, Cardiovascular Disease
Interventions
Fructose, Fructose and Glucose
Dietary Supplement
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2013 · Synced Sep 12, 2026, 4:35 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Glycemic Index of Commonly Consumed Sweeteners

NCT02931578
View directory record Official record
Conditions
Healthy
Interventions
Glucose100, Glucose50, Glucose42, Oral Glucose Tolerance Test
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 25, 2019 · Synced Sep 12, 2026, 4:35 AM EDT
Recruiting Phase 4 Interventional

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

NCT07058155
View directory record Official record
Conditions
Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
Interventions
Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect), Lifestyle Counseling - Diet & Physical-Activity Program
Procedure · Drug · Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2034
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Microbiome Fructan Metabolism and Symptoms in Childhood IBS

NCT02842281
View directory record Official record
Conditions
Irritable Bowel Syndrome (IBS)
Interventions
Fructan, Maltodextrin
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
7 Years to 17 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Carbohydrate Type and Cardiovascular Disease (CVD) Risk Indicators

NCT01610661
View directory record Official record
Conditions
Dyslipidemia
Interventions
Diet
Other
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects

NCT00329407
View directory record Official record
Conditions
Alcoholism
Interventions
Topiramate (Topamax)
Drug
Lead sponsor
Boston University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 7, 2010 · Synced Sep 12, 2026, 4:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Optimized Carbohydrate Fueling to Enhance Physical Performance During Energy Deficit

NCT06394401
View directory record Official record
Conditions
Energy Supply; Deficiency
Interventions
BAL:GLU, BAL:GLU+FRU, DEF:GLU, DEF:GLU+FRU
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 12, 2026, 4:35 AM EDT
Terminated Phase 2 Interventional Results available

Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism

NCT00862563
View directory record Official record
Conditions
Alcoholism, Alcohol Dependence, Alcohol Abuse
Interventions
Topiramate, Zonisamide, Levetiracetam, Sugar Pill
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Dietary Treatment of Crohn's Disease

NCT00343642
View directory record Official record
Conditions
Crohn's Disease, Inflammatory Bowel Disease
Interventions
Active fructo-oligosaccharide, Placebo fructo-oligosaccharide, Diet
Drug · Dietary Supplement
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
2
States / cities
Macon, Georgia • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Phase 4 Interventional Results available

Topiramate Treatment of Problem Drinkers

NCT00626925
View directory record Official record
Conditions
Alcohol Drinking
Interventions
topiramate, placebo
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Sep 12, 2026, 4:35 AM EDT
Terminated Not applicable Interventional

Randomized Control Trial of L-Alanine and Placebo in Fructose Intolerance

NCT01288495
View directory record Official record
Conditions
Dietary Fructose Intolerance
Interventions
supplemental L-alanine, Metamucil
Dietary Supplement
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Monocyte Priming When Consuming a Western Diet

NCT05348395
View directory record Official record
Conditions
Heart Diseases
Interventions
Experimental diet
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
20 Years to 45 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Characterizing and Predicting Drug Effects on Cognition

NCT01889602
View directory record Official record
Conditions
Cognitive Deficits
Interventions
Lorazepam, Placebo, Topiramate 100mg, Topiramate 150mg, Topiramate 200mg
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Different Carbohydrate Feedings on a Hydrogen Breath Curve and Self-reported Gastrointestinal Complaints

NCT06648967
View directory record Official record
Conditions
Quality of Life
Interventions
Supplementation with a multi-ingredient whey supplement
Dietary Supplement
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 60 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 12, 2026, 4:35 AM EDT
Recruiting Phase 4 Interventional

Treatment of Meniere's Disease With Migraine Medications

NCT05582837
View directory record Official record
Conditions
Ménière
Interventions
nortriptyline + topiramate
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
25 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Not applicable Interventional

FODMAP Reintroduction in Irritable Bowel Syndrome

NCT03245645
View directory record Official record
Conditions
Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome With Mixed Bowel Habits
Interventions
Dietary Intervention
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Sep 12, 2026, 4:35 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Topiramate and Prolonged Exposure

NCT03176953
View directory record Official record
Conditions
PTSD and Alcohol Use Disorder
Interventions
topiramate, prolonged exposure, placebo
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 12, 2026, 4:35 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy

NCT01765218
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Topiramate, Placebo
Drug
Lead sponsor
Kristin R Hoffman
Other
Eligibility
Up to 6 Hours
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Sep 12, 2026, 4:35 AM EDT