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Showing 1–24 of 124 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: gum chewing Clear all
Terminated Not applicable Interventional

Does Chewing Gum After Elective Laparoscopic Colectomy Surgery Decrease Ileus?

NCT00632801
View directory record Official record
Conditions
Ileus
Interventions
chewing gum
Other
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 89 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking Cessation for Young Adult Pacific Islanders: Motivating Pacifika Against Cigarettes and Tobacco

NCT03238456
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Smoking, Smoking Cessation, Smoking, Cigarette
Interventions
Motivating Pacifika Against Cigarettes and Tobacco
Behavioral
Lead sponsor
Claremont Graduate University
Other
Eligibility
18 Years to 30 Years
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Claremont, California • Fullerton, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2017 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Gum Chewing on Energy Intake and Expenditure

NCT01043471
View directory record Official record
Conditions
Obesity
Interventions
Chewing gum, Water
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 38 Years · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional Results available

WeChat Quit Coach Pilot Study

NCT05130788
View directory record Official record
Conditions
Smoking Cessation
Interventions
WeChat Quit Coach, Leaflet, Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges
Behavioral · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Validation of Biomarkers of Exposure and Host Response

NCT00468234
View directory record Official record
Conditions
Cigarette Smoker
Interventions
nicotine polacrilex, nicotine transdermal system, nicotine inhaler
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Sep 10, 2026, 3:19 AM EDT
Recruiting Not applicable Interventional

Effects of Hard Gum Chewing on Facial Soft Tissue Morphology

NCT07726511
View directory record Official record
Conditions
Face
Interventions
Hard Gum Chewing
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
20 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 10, 2026, 3:19 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Impact of Sleep Deprivation and Caffeine in Medical Professionals

NCT04273841
View directory record Official record
Conditions
Sleep Deprivation, Performance
Interventions
Military Energy Gum, Placebo Gum
Dietary Supplement
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 50 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional

Salivary Gland Autotransplantation for Treatment of XRT Induced Xerostomia

NCT04007081
View directory record Official record
Conditions
Xerostomia, Head and Neck Cancer
Interventions
Bone Marrow Aspiration, Ultrasound Imaging of Salivary Glands, Salivary Assay, Quality of Life Instruments
Procedure · Diagnostic Test · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Sep 10, 2026, 3:19 AM EDT
Not yet recruiting Not applicable Interventional

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

NCT07714200
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Methods Project 4: Clinical Trial - Amended

NCT03111537
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Cigarettes, E-Cigarette, Nicotine Gum or Lozenge
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
3
States / cities
Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional Results available

Patch Study - Intervention for HIV Positive Smokers

NCT02982772
View directory record Official record
Conditions
Smoking Cessation, HIV
Interventions
Combination Therapy, Standard Care Intervention
Other
Lead sponsor
dr. maria miguez
Other
Eligibility
18 Years and older
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Chewing Gum for Weight Loss

NCT00971347
View directory record Official record
Conditions
Obesity, Overweight, Weight Loss
Interventions
Extra sugar-free chewing gum sticks, nutrition brochure
Other · Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 22, 2010 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes

NCT03559725
View directory record Official record
Conditions
Tobacco Use
Interventions
VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C)
Other · Drug
Lead sponsor
22nd Century Group, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Sep 10, 2026, 3:19 AM EDT
Not yet recruiting Not applicable Interventional

Quit-Smoking Study for Native Hawaiians

NCT07075575
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation
Interventions
Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT)
Drug · Behavioral
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 10, 2026, 3:19 AM EDT
Terminated Phase 4 Interventional Results available

Nicotine Gum Recovery After Colorectal Surgery

NCT01662115
View directory record Official record
Conditions
Post-operative Ileus
Interventions
Nicotine gum, Regular chewing gum
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon

NCT05157672
View directory record Official record
Conditions
Interaction Drug Food
Interventions
Cinnamon (2 g), Nicotine gum (2.5 mg), Letrozole (2.5 mg)
Dietary Supplement · Drug
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 64 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 10, 2026, 3:19 AM EDT
Active, not recruiting Phase 4 Interventional

Smoking Cessation Program in the Construction Sector

NCT06098144
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking
Interventions
Nicorette, Tobacco Quit-line, Brief Behavioral Counseling, Intensive Behavioral Counseling
Drug · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Not applicable Interventional

Chewing Gum Facilitates an Earlier Return to Bowel Function in Pediatric Scoliosis Patients: A Prospective Randomized Study

NCT02165436
View directory record Official record
Conditions
Scoliosis
Interventions
Chewing gum, Control
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 18 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Enhanced Recovery at Cesarean Birth to Improve Postoperative Outcomes and Reduce Postoperative Length of Stay

NCT02956616
View directory record Official record
Conditions
Cesarean Section
Interventions
ketorolac, Chewing Gum, Enhanced Recovery Protocol
Drug · Other · Procedure
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Sep 10, 2026, 3:19 AM EDT
Active, not recruiting Not applicable Interventional

Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy

NCT07320989
View directory record Official record
Conditions
Colon Cancer Screening
Interventions
Chewing Sugar-Free Gum During Bowel Preparation, Standard Bowel Prep (2L PEG-ELP), Standard Bowel Prep
Behavioral · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
45 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Diet as a Potential Treatment for Autosomal Dominant Polycystic Kidney Disease

NCT02225860
View directory record Official record
Conditions
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions
Diet and water adjustment
Behavioral
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Sep 10, 2026, 3:19 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Smoking Cessation in Hispanic Construction Workers

NCT02873377
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicorette Gum, Nicoderm CQ, Smoking Quitline Referral, Behavioral Smoking Cessation Counseling
Drug · Other · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older · Male only
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 6, 2019 · Synced Sep 10, 2026, 3:19 AM EDT
Terminated Phase 4 Interventional Results available

e-Cigarettes Versus NRT Gum for Smoking Cessation

NCT01925781
View directory record Official record
Conditions
Nicotine Addiction, Smoking Cessation
Interventions
Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer
Drug · Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Sep 10, 2026, 3:19 AM EDT
Recruiting No phase listed Observational

Microbiome in Head and Neck Squamous Cell Carcinoma

NCT05837221
View directory record Official record
Conditions
Head and Neck Cancer, Lip Cancer, Oral Cancer, Pharynx Cancer
Interventions
Metagenomic sequencing, Metabolic analysis
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Sep 10, 2026, 3:19 AM EDT