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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:17 AM EST

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Showing 73–96 of 127 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: gum chewing Clear all

Conditions: Cigarette Smoking, Marijuana Abuse
Interventions: bupropion, transdermal nicotine patch, Nicotine polacrilex, nicotine lozenge, counseling for marijuana and smoking cessation, mobile contingency management; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Bad Breath, Tooth Sensitivity
Interventions: Larineco Remineralizing Gum; Dietary Supplement
Lead sponsor: Larine C Corporation; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Smoking Cessation
Interventions: Group Counseling, Individual Counseling, Phone Counseling, Video Counseling, Texting support, Nicotine Replacement Therapy; Behavioral · Drug
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions: Diet and water adjustment; Behavioral
Lead sponsor: Tufts Medical Center; Other
Eligibility: 18 Years to 60 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Stress Disorders, Post-Traumatic, Smoking
Interventions: Cognitive Processing Therapy (CPT), Bupropion, nicotine replacement therapy (NRT), Integrated Care for Smoking Cessation (ICSC), smokefreeVET; Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Face
Interventions: Hard Gum Chewing; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 20 Years to 40 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Nicotine Dependence, Tobacco Use
Interventions: Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge, Bupropion, Varenicline, Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Tobacco quitline referral, Tailored behavioral intervention, Alcohol use risk reduction, Behavioral activation for depressive symptoms, Behavioral management of postcessation weight gain; Drug · Behavioral
Lead sponsor: Mark Vander Weg; Other
Eligibility: 18 Years to 99 Years
Enrollment: 411 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Perforated Appendicitis
Interventions: Motion sickness wristband, Chewing Gum; Device · Dietary Supplement
Lead sponsor: Wake Forest University; Other
Eligibility: 6 Years to 18 Years
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Tinnitus, Chronic Subjective Tinnitus
Interventions: Nicotine polacrilex gum 4 mg, Placebo gum; Drug · Other
Lead sponsor: San Diego State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Diego, California

Conditions: Smoking Cessation
Interventions: Nicorette Gum, Nicoderm CQ, Smoking Quitline Referral, Behavioral Smoking Cessation Counseling; Drug · Other · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older · Male only
Enrollment: 134 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Tobacco Use Disorder/Cigarette Smoking, HIV
Interventions: nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 794 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 5
States / cities: Bridgeport, Connecticut • New Haven, Connecticut • Jersey City, New Jersey + 2 more

Conditions: Tobacco Use
Interventions: VLN cigarettes (A), Usual Brand Cigarettes (B), Nicotine gum (C); Other · Drug
Lead sponsor: 22nd Century Group, Inc.; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Habituation
Interventions: NO GUM, MCC (Mint Chocolate Chip gum), C (Cinnamon gum); Other
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 18 Years to 40 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2025
U.S. locations: 1
States / cities: Knoxville, Tennessee

Conditions: Hyperphosphatemia, Chronic Kidney Disease
Interventions: K2CG chewing gum; Other
Lead sponsor: Denver Nephrologists, P.C.; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Dental Caries
Interventions: Chlorhexidine mouth rinse, Xylitol chewing gum; Drug · Other
Lead sponsor: University of Washington; Other
Eligibility: Female only
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco Dependence
Interventions: Nicotine Patch, Nicotine Gum; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 13 Years to 17 Years
Enrollment: 157 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2004
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Dental Caries
Interventions: Chlorhexidine gluconate (0.12%), Sodium Fluoride (0.05%), Paraffin wax chewing gum (sugar-free), Deionized water; Drug · Other
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 6 Years to 12 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Hunger
Interventions: Chewing Gum, No Gum; Dietary Supplement
Lead sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking Cessation, Harm Reduction
Interventions: Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, BIDI e-cigarette, on!; Drug · Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Colon Cancer Screening
Interventions: Chewing Sugar-Free Gum During Bowel Preparation, Standard Bowel Prep (2L PEG-ELP), Standard Bowel Prep; Behavioral · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 45 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Towson, Maryland

Conditions: Smoking
Interventions: Nicotine gum - 2 mg and 4 mg, Nicotine lozenges - 2 mg and 4 mg, Nicotine inhaler (4 mg yield) - low and high "dosage" by frequency of puffing, Computer learning; Drug · Other
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 21 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: West Los Angeles, California

Conditions: Postoperative Ileus
Interventions: Chewing gum; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 294 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Scoliosis
Interventions: Chewing gum, Control; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 10 Years to 18 Years
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Chronic Kidney Disease
Interventions: chewing gum; Other
Lead sponsor: Denver Nephrologists, P.C.; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Denver, Colorado

Search by objective public record fields.

Mobile Contingency Management for Marijuana and Tobacco Cessation

A Clinical Trial to Evaluate the Effects of Larineco Remineralizing Gum on Oral Health, Breath Freshness, Tooth Sensitivity, and Gum Comfort

End Nicotine Dependence Clinic

Diet as a Potential Treatment for Autosomal Dominant Polycystic Kidney Disease

CPT and Smoking Cessation

Effects of Hard Gum Chewing on Facial Soft Tissue Morphology

Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers

The Effect of Gum Chewing on Postoperative Ileus

Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus

Smoking Cessation in Hispanic Construction Workers

Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial

Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes

The Effects of Chewing Gum on a Computer Task and Liking Ratings of Ice Cream

PD Study to Assess Phosphate Binding Characteristics of K2CG Chewing Gum

Caries Transmission Prevention in Alaska Native Infants

Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence

Comparing Mouth Rinses (and Chewing Gum) in Regard to Streptococcus Mutans Reduction

A Study of Chewing Gum, Snacking and Appetite

Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT

Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy

Nicotine Delivery Systems: Research & Treatment

The Effect of Gum Chewing on Postoperative Ileus After Gynecologic Surgery

Chewing Gum Facilitates an Earlier Return to Bowel Function in Pediatric Scoliosis Patients: A Prospective Randomized Study

Phosphate Binding of Chitosan Chewing Gum in Patients With Chronic Kidney Disease (CKD)